Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol

Autores
Salerno, Claudia; Carlucci, Adriana Mónica; Chiappetta, Diego Andrés; Bregni, Carlos
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG 10 %. Candida albicans was used as a model fungus and a procedure with standardized inoculum concentration was used. Results showed lower antifungal activity of fluconazole solutions and topical dosage forms when propylene glycol is included. Although crystallization is faster in PG solutions, solubility proved not to be the cause, but changes in FTIR spectra suggested that different hydrogen bond formation could explain the decrease in activity.
Fil: Salerno, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Carlucci, Adriana Mónica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Materia
Antifungal activity
Fluconazole
Hydrogen bonding
Propylene glycol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/113683
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene GlycolSalerno, ClaudiaCarlucci, Adriana MónicaChiappetta, Diego AndrésBregni, CarlosAntifungal activityFluconazoleHydrogen bondingPropylene glycolhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG 10 %. Candida albicans was used as a model fungus and a procedure with standardized inoculum concentration was used. Results showed lower antifungal activity of fluconazole solutions and topical dosage forms when propylene glycol is included. Although crystallization is faster in PG solutions, solubility proved not to be the cause, but changes in FTIR spectra suggested that different hydrogen bond formation could explain the decrease in activity.Fil: Salerno, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Carlucci, Adriana Mónica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaColegio de Farmacéuticos de la Provincia de Buenos Aires2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/113683Salerno, Claudia; Carlucci, Adriana Mónica; Chiappetta, Diego Andrés; Bregni, Carlos; Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 7; 7-2011; 1406-14130326-2383CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:49Zoai:ri.conicet.gov.ar:11336/113683instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:49.746CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
title Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
spellingShingle Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
Salerno, Claudia
Antifungal activity
Fluconazole
Hydrogen bonding
Propylene glycol
title_short Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
title_full Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
title_fullStr Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
title_full_unstemmed Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
title_sort Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
dc.creator.none.fl_str_mv Salerno, Claudia
Carlucci, Adriana Mónica
Chiappetta, Diego Andrés
Bregni, Carlos
author Salerno, Claudia
author_facet Salerno, Claudia
Carlucci, Adriana Mónica
Chiappetta, Diego Andrés
Bregni, Carlos
author_role author
author2 Carlucci, Adriana Mónica
Chiappetta, Diego Andrés
Bregni, Carlos
author2_role author
author
author
dc.subject.none.fl_str_mv Antifungal activity
Fluconazole
Hydrogen bonding
Propylene glycol
topic Antifungal activity
Fluconazole
Hydrogen bonding
Propylene glycol
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG 10 %. Candida albicans was used as a model fungus and a procedure with standardized inoculum concentration was used. Results showed lower antifungal activity of fluconazole solutions and topical dosage forms when propylene glycol is included. Although crystallization is faster in PG solutions, solubility proved not to be the cause, but changes in FTIR spectra suggested that different hydrogen bond formation could explain the decrease in activity.
Fil: Salerno, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Carlucci, Adriana Mónica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
description Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG 10 %. Candida albicans was used as a model fungus and a procedure with standardized inoculum concentration was used. Results showed lower antifungal activity of fluconazole solutions and topical dosage forms when propylene glycol is included. Although crystallization is faster in PG solutions, solubility proved not to be the cause, but changes in FTIR spectra suggested that different hydrogen bond formation could explain the decrease in activity.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/113683
Salerno, Claudia; Carlucci, Adriana Mónica; Chiappetta, Diego Andrés; Bregni, Carlos; Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 7; 7-2011; 1406-1413
0326-2383
CONICET Digital
CONICET
url http://hdl.handle.net/11336/113683
identifier_str_mv Salerno, Claudia; Carlucci, Adriana Mónica; Chiappetta, Diego Andrés; Bregni, Carlos; Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 7; 7-2011; 1406-1413
0326-2383
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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