Ambient mass spectrometry technologies for the detection of falsified drugs

Autores
Culzoni, Maria Julia; Dwivedi, Prabha; Green, Michael D.; Newton, Paul; Fernandez, Facundo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Increased globalization of the pharmaceutical market has facilitated the unobstructed and fast spread of poor-quality medicines. Poor-quality medicines include spurious/falsely-labeled/falsified/counterfeit drugs (those that are deliberately and fraudulently mislabeled with respect to content and/or origin), substandard drugs (legitimate drugs that do not meet their quality specifications), and degraded medicines (good quality pharmaceuticals that suffered from deterioration caused by improper storage or distribution). Consumption of poor-quality pharmaceuticals is likely to increase morbidity and mortality.
Moreover, poor-quality drugs can also contribute to the development of resistance to anti-infective medicines and decrease the quality of health care received by patients. To assess the true prevalence of poor quality drugs, tiered technology approaches enabling the testing of drug samples collected at points of sale are required, thus ensuring public health standards. High throughput and high resolution ambient mass spectrometry techniques allow investigation of pharmaceuticals with minimal or no sample preparation, thus possessing capabilities to survey a large number of drug samples for their authenticity.
Fil: Culzoni, Maria Julia. Georgia Institute Of Techology; Estados Unidos. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Dwivedi, Prabha. Georgia Institute Of Techology; Estados Unidos
Fil: Green, Michael D.. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos
Fil: Newton, Paul. Mahosot Hospital; Laos. University of Oxford; Reino Unido
Fil: Fernandez, Facundo. Georgia Institute Of Techology; Estados Unidos
Materia
AMBIENT MASS SPECTROMETRY
FALSIFIED DRUGS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6387
Acceder
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spelling Ambient mass spectrometry technologies for the detection of falsified drugsCulzoni, Maria JuliaDwivedi, PrabhaGreen, Michael D.Newton, PaulFernandez, FacundoAMBIENT MASS SPECTROMETRYFALSIFIED DRUGShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Increased globalization of the pharmaceutical market has facilitated the unobstructed and fast spread of poor-quality medicines. Poor-quality medicines include spurious/falsely-labeled/falsified/counterfeit drugs (those that are deliberately and fraudulently mislabeled with respect to content and/or origin), substandard drugs (legitimate drugs that do not meet their quality specifications), and degraded medicines (good quality pharmaceuticals that suffered from deterioration caused by improper storage or distribution). Consumption of poor-quality pharmaceuticals is likely to increase morbidity and mortality.<br />Moreover, poor-quality drugs can also contribute to the development of resistance to anti-infective medicines and decrease the quality of health care received by patients. To assess the true prevalence of poor quality drugs, tiered technology approaches enabling the testing of drug samples collected at points of sale are required, thus ensuring public health standards. High throughput and high resolution ambient mass spectrometry techniques allow investigation of pharmaceuticals with minimal or no sample preparation, thus possessing capabilities to survey a large number of drug samples for their authenticity.Fil: Culzoni, Maria Julia. Georgia Institute Of Techology; Estados Unidos. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Dwivedi, Prabha. Georgia Institute Of Techology; Estados UnidosFil: Green, Michael D.. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados UnidosFil: Newton, Paul. Mahosot Hospital; Laos. University of Oxford; Reino UnidoFil: Fernandez, Facundo. Georgia Institute Of Techology; Estados UnidosRoyal Society of Chemistry2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6387Culzoni, Maria Julia; Dwivedi, Prabha; Green, Michael D.; Newton, Paul; Fernandez, Facundo; Ambient mass spectrometry technologies for the detection of falsified drugs; Royal Society of Chemistry; MedChemComm; 5; 1; 10-2013; 9-192040-2503enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/MD/c3md00235ginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1039/C3MD00235Ginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:15Zoai:ri.conicet.gov.ar:11336/6387instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:15.64CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ambient mass spectrometry technologies for the detection of falsified drugs
title Ambient mass spectrometry technologies for the detection of falsified drugs
spellingShingle Ambient mass spectrometry technologies for the detection of falsified drugs
Culzoni, Maria Julia
AMBIENT MASS SPECTROMETRY
FALSIFIED DRUGS
title_short Ambient mass spectrometry technologies for the detection of falsified drugs
title_full Ambient mass spectrometry technologies for the detection of falsified drugs
title_fullStr Ambient mass spectrometry technologies for the detection of falsified drugs
title_full_unstemmed Ambient mass spectrometry technologies for the detection of falsified drugs
title_sort Ambient mass spectrometry technologies for the detection of falsified drugs
dc.creator.none.fl_str_mv Culzoni, Maria Julia
Dwivedi, Prabha
Green, Michael D.
Newton, Paul
Fernandez, Facundo
author Culzoni, Maria Julia
author_facet Culzoni, Maria Julia
Dwivedi, Prabha
Green, Michael D.
Newton, Paul
Fernandez, Facundo
author_role author
author2 Dwivedi, Prabha
Green, Michael D.
Newton, Paul
Fernandez, Facundo
author2_role author
author
author
author
dc.subject.none.fl_str_mv AMBIENT MASS SPECTROMETRY
FALSIFIED DRUGS
topic AMBIENT MASS SPECTROMETRY
FALSIFIED DRUGS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Increased globalization of the pharmaceutical market has facilitated the unobstructed and fast spread of poor-quality medicines. Poor-quality medicines include spurious/falsely-labeled/falsified/counterfeit drugs (those that are deliberately and fraudulently mislabeled with respect to content and/or origin), substandard drugs (legitimate drugs that do not meet their quality specifications), and degraded medicines (good quality pharmaceuticals that suffered from deterioration caused by improper storage or distribution). Consumption of poor-quality pharmaceuticals is likely to increase morbidity and mortality.<br />Moreover, poor-quality drugs can also contribute to the development of resistance to anti-infective medicines and decrease the quality of health care received by patients. To assess the true prevalence of poor quality drugs, tiered technology approaches enabling the testing of drug samples collected at points of sale are required, thus ensuring public health standards. High throughput and high resolution ambient mass spectrometry techniques allow investigation of pharmaceuticals with minimal or no sample preparation, thus possessing capabilities to survey a large number of drug samples for their authenticity.
Fil: Culzoni, Maria Julia. Georgia Institute Of Techology; Estados Unidos. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Dwivedi, Prabha. Georgia Institute Of Techology; Estados Unidos
Fil: Green, Michael D.. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos
Fil: Newton, Paul. Mahosot Hospital; Laos. University of Oxford; Reino Unido
Fil: Fernandez, Facundo. Georgia Institute Of Techology; Estados Unidos
description Increased globalization of the pharmaceutical market has facilitated the unobstructed and fast spread of poor-quality medicines. Poor-quality medicines include spurious/falsely-labeled/falsified/counterfeit drugs (those that are deliberately and fraudulently mislabeled with respect to content and/or origin), substandard drugs (legitimate drugs that do not meet their quality specifications), and degraded medicines (good quality pharmaceuticals that suffered from deterioration caused by improper storage or distribution). Consumption of poor-quality pharmaceuticals is likely to increase morbidity and mortality.<br />Moreover, poor-quality drugs can also contribute to the development of resistance to anti-infective medicines and decrease the quality of health care received by patients. To assess the true prevalence of poor quality drugs, tiered technology approaches enabling the testing of drug samples collected at points of sale are required, thus ensuring public health standards. High throughput and high resolution ambient mass spectrometry techniques allow investigation of pharmaceuticals with minimal or no sample preparation, thus possessing capabilities to survey a large number of drug samples for their authenticity.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6387
Culzoni, Maria Julia; Dwivedi, Prabha; Green, Michael D.; Newton, Paul; Fernandez, Facundo; Ambient mass spectrometry technologies for the detection of falsified drugs; Royal Society of Chemistry; MedChemComm; 5; 1; 10-2013; 9-19
2040-2503
url http://hdl.handle.net/11336/6387
identifier_str_mv Culzoni, Maria Julia; Dwivedi, Prabha; Green, Michael D.; Newton, Paul; Fernandez, Facundo; Ambient mass spectrometry technologies for the detection of falsified drugs; Royal Society of Chemistry; MedChemComm; 5; 1; 10-2013; 9-19
2040-2503
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/MD/c3md00235g
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1039/C3MD00235G
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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