Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives
- Autores
- de Macedo Henrique, Izabella; Sacerdoti, Flavia; Lozzardo Ferreira, Raissa; Henrique, Camila; Amaral, María Marta; Fontes Piazza, Roxane María; Luz, Daniela
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Shiga toxins (Stx) are AB5-type toxins, composed of five B subunits which bind to Gb3 host cell receptors and an active A subunit, whose action on the ribosome leads to protein synthesis suppression. The two Stx types (Stx1 and Stx2) and their subtypes can be produced by Shiga toxin-producing Escherichia coli strains and some Shigella spp. These bacteria colonize the colon and induce diarrhea that may progress to hemorrhagic colitis and in the most severe cases, to hemolytic uremic syndrome, which could lead to death. Since the use of antibiotics in these infections is a topic of great controversy, the treatment remains supportive and there are no specific therapies to ameliorate the course. Therefore, there is an open window for Stx neutralization employing antibodies, which are versatile molecules. Indeed, polyclonal, monoclonal, and recombinant antibodies have been raised and tested in vitro and in vivo assays, showing differences in their neutralizing ability against deleterious effects of Stx. These molecules are in different phases of development for which we decide to present herein an updated report of these antibody molecules, their source, advantages, and disadvantages of the promising ones, as well as the challenges faced until reaching their applicability.
Fil: de Macedo Henrique, Izabella. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil
Fil: Sacerdoti, Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Lozzardo Ferreira, Raissa. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil
Fil: Henrique, Camila. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil
Fil: Amaral, María Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Fontes Piazza, Roxane María. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil
Fil: Luz, Daniela. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil - Materia
-
ANTIBODIES
SHIGA TOXIN-PRODUCING E. COLI
STX TOXINS
THERAPY
TRENDS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/204054
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Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectivesde Macedo Henrique, IzabellaSacerdoti, FlaviaLozzardo Ferreira, RaissaHenrique, CamilaAmaral, María MartaFontes Piazza, Roxane MaríaLuz, DanielaANTIBODIESSHIGA TOXIN-PRODUCING E. COLISTX TOXINSTHERAPYTRENDShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Shiga toxins (Stx) are AB5-type toxins, composed of five B subunits which bind to Gb3 host cell receptors and an active A subunit, whose action on the ribosome leads to protein synthesis suppression. The two Stx types (Stx1 and Stx2) and their subtypes can be produced by Shiga toxin-producing Escherichia coli strains and some Shigella spp. These bacteria colonize the colon and induce diarrhea that may progress to hemorrhagic colitis and in the most severe cases, to hemolytic uremic syndrome, which could lead to death. Since the use of antibiotics in these infections is a topic of great controversy, the treatment remains supportive and there are no specific therapies to ameliorate the course. Therefore, there is an open window for Stx neutralization employing antibodies, which are versatile molecules. Indeed, polyclonal, monoclonal, and recombinant antibodies have been raised and tested in vitro and in vivo assays, showing differences in their neutralizing ability against deleterious effects of Stx. These molecules are in different phases of development for which we decide to present herein an updated report of these antibody molecules, their source, advantages, and disadvantages of the promising ones, as well as the challenges faced until reaching their applicability.Fil: de Macedo Henrique, Izabella. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFil: Sacerdoti, Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Lozzardo Ferreira, Raissa. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFil: Henrique, Camila. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFil: Amaral, María Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Fontes Piazza, Roxane María. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFil: Luz, Daniela. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFrontiers Media2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/204054de Macedo Henrique, Izabella; Sacerdoti, Flavia; Lozzardo Ferreira, Raissa; Henrique, Camila; Amaral, María Marta; et al.; Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 12; 2-2022; 1-152235-2988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2022.825856/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2022.825856info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:10Zoai:ri.conicet.gov.ar:11336/204054instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:11.176CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
title |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
spellingShingle |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives de Macedo Henrique, Izabella ANTIBODIES SHIGA TOXIN-PRODUCING E. COLI STX TOXINS THERAPY TRENDS |
title_short |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
title_full |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
title_fullStr |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
title_full_unstemmed |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
title_sort |
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives |
dc.creator.none.fl_str_mv |
de Macedo Henrique, Izabella Sacerdoti, Flavia Lozzardo Ferreira, Raissa Henrique, Camila Amaral, María Marta Fontes Piazza, Roxane María Luz, Daniela |
author |
de Macedo Henrique, Izabella |
author_facet |
de Macedo Henrique, Izabella Sacerdoti, Flavia Lozzardo Ferreira, Raissa Henrique, Camila Amaral, María Marta Fontes Piazza, Roxane María Luz, Daniela |
author_role |
author |
author2 |
Sacerdoti, Flavia Lozzardo Ferreira, Raissa Henrique, Camila Amaral, María Marta Fontes Piazza, Roxane María Luz, Daniela |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ANTIBODIES SHIGA TOXIN-PRODUCING E. COLI STX TOXINS THERAPY TRENDS |
topic |
ANTIBODIES SHIGA TOXIN-PRODUCING E. COLI STX TOXINS THERAPY TRENDS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Shiga toxins (Stx) are AB5-type toxins, composed of five B subunits which bind to Gb3 host cell receptors and an active A subunit, whose action on the ribosome leads to protein synthesis suppression. The two Stx types (Stx1 and Stx2) and their subtypes can be produced by Shiga toxin-producing Escherichia coli strains and some Shigella spp. These bacteria colonize the colon and induce diarrhea that may progress to hemorrhagic colitis and in the most severe cases, to hemolytic uremic syndrome, which could lead to death. Since the use of antibiotics in these infections is a topic of great controversy, the treatment remains supportive and there are no specific therapies to ameliorate the course. Therefore, there is an open window for Stx neutralization employing antibodies, which are versatile molecules. Indeed, polyclonal, monoclonal, and recombinant antibodies have been raised and tested in vitro and in vivo assays, showing differences in their neutralizing ability against deleterious effects of Stx. These molecules are in different phases of development for which we decide to present herein an updated report of these antibody molecules, their source, advantages, and disadvantages of the promising ones, as well as the challenges faced until reaching their applicability. Fil: de Macedo Henrique, Izabella. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil Fil: Sacerdoti, Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Lozzardo Ferreira, Raissa. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil Fil: Henrique, Camila. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil Fil: Amaral, María Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Fontes Piazza, Roxane María. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil Fil: Luz, Daniela. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil |
description |
Shiga toxins (Stx) are AB5-type toxins, composed of five B subunits which bind to Gb3 host cell receptors and an active A subunit, whose action on the ribosome leads to protein synthesis suppression. The two Stx types (Stx1 and Stx2) and their subtypes can be produced by Shiga toxin-producing Escherichia coli strains and some Shigella spp. These bacteria colonize the colon and induce diarrhea that may progress to hemorrhagic colitis and in the most severe cases, to hemolytic uremic syndrome, which could lead to death. Since the use of antibiotics in these infections is a topic of great controversy, the treatment remains supportive and there are no specific therapies to ameliorate the course. Therefore, there is an open window for Stx neutralization employing antibodies, which are versatile molecules. Indeed, polyclonal, monoclonal, and recombinant antibodies have been raised and tested in vitro and in vivo assays, showing differences in their neutralizing ability against deleterious effects of Stx. These molecules are in different phases of development for which we decide to present herein an updated report of these antibody molecules, their source, advantages, and disadvantages of the promising ones, as well as the challenges faced until reaching their applicability. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/204054 de Macedo Henrique, Izabella; Sacerdoti, Flavia; Lozzardo Ferreira, Raissa; Henrique, Camila; Amaral, María Marta; et al.; Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 12; 2-2022; 1-15 2235-2988 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/204054 |
identifier_str_mv |
de Macedo Henrique, Izabella; Sacerdoti, Flavia; Lozzardo Ferreira, Raissa; Henrique, Camila; Amaral, María Marta; et al.; Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 12; 2-2022; 1-15 2235-2988 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2022.825856/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2022.825856 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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