Electron emission from bromouracil and uracil induced by protons and radiosensitization

Autores
Roy Chowdhury, Madhusree; Monti, Juan Manuel; Misra, Deepankar; Weck, Philippe F.; Rivarola, Roberto Daniel; Tribedi, Lokesh C.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Absolute double differential cross sections (DDCS) of electrons emitted from uracil and 5-bromouracil (BrU) in collisions with protons of energy 200 keV have been measured for various forward and backward emission angles over wide range of electron energies. The measured DDCS are compared with the continuum distorted wave-eikonal initial state (CDW-EIS) calculations. The optimized structure of the BrU was estimated along with the population analysis of all the occupied orbitals using a self-consistent field density. A comparison between the measured DDCS data for the two molecules show that the cross section of low energy electrons emitted from BrU is substantially larger than that for uracil. The BrU-to-uracil DDCS ratios obtained from the present measurements indicate an enhancement of the electron emission by a factor which is as large as 2.0 to 2.5. These electrons being the major agent for damaging the DNA/RNA of the malignant tissues, the present results are expected to provide an important input for the radiosensitization effect in hadron therapy. It is noteworthy to mention that the CDW-EIS calculations for Coulomb ionization cannot predict such enhancement. A large angular asymmetry is observed for uracil with a broad structure, which is absent in case of BrU.
Fil: Roy Chowdhury, Madhusree. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España
Fil: Monti, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Fil: Misra, Deepankar. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España
Fil: Weck, Philippe F.. No especifíca;
Fil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Fil: Tribedi, Lokesh C.. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España
Materia
CDW-EIS
DOUBLE DIFFERENTIAL CROSS SECTION
ELECTRON SPECTROSCOPY
FORWARD-BACKWARD ANGULAR ASYMMETRY
HALOURACILS
RADIOSENSITIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/219148
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/219148
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electron emission from bromouracil and uracil induced by protons and radiosensitizationRoy Chowdhury, MadhusreeMonti, Juan ManuelMisra, DeepankarWeck, Philippe F.Rivarola, Roberto DanielTribedi, Lokesh C.CDW-EISDOUBLE DIFFERENTIAL CROSS SECTIONELECTRON SPECTROSCOPYFORWARD-BACKWARD ANGULAR ASYMMETRYHALOURACILSRADIOSENSITIZATIONhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Absolute double differential cross sections (DDCS) of electrons emitted from uracil and 5-bromouracil (BrU) in collisions with protons of energy 200 keV have been measured for various forward and backward emission angles over wide range of electron energies. The measured DDCS are compared with the continuum distorted wave-eikonal initial state (CDW-EIS) calculations. The optimized structure of the BrU was estimated along with the population analysis of all the occupied orbitals using a self-consistent field density. A comparison between the measured DDCS data for the two molecules show that the cross section of low energy electrons emitted from BrU is substantially larger than that for uracil. The BrU-to-uracil DDCS ratios obtained from the present measurements indicate an enhancement of the electron emission by a factor which is as large as 2.0 to 2.5. These electrons being the major agent for damaging the DNA/RNA of the malignant tissues, the present results are expected to provide an important input for the radiosensitization effect in hadron therapy. It is noteworthy to mention that the CDW-EIS calculations for Coulomb ionization cannot predict such enhancement. A large angular asymmetry is observed for uracil with a broad structure, which is absent in case of BrU.Fil: Roy Chowdhury, Madhusree. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Monti, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Misra, Deepankar. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Weck, Philippe F.. No especifíca;Fil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Tribedi, Lokesh C.. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaIOP Publishing2022-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/219148Roy Chowdhury, Madhusree; Monti, Juan Manuel; Misra, Deepankar; Weck, Philippe F.; Rivarola, Roberto Daniel; et al.; Electron emission from bromouracil and uracil induced by protons and radiosensitization; IOP Publishing; New Journal of Physics; 24; 7; 7-2022; 1-111367-2630CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1088/1367-2630/ac7e65info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:27Zoai:ri.conicet.gov.ar:11336/219148instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:27.652CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electron emission from bromouracil and uracil induced by protons and radiosensitization
title Electron emission from bromouracil and uracil induced by protons and radiosensitization
spellingShingle Electron emission from bromouracil and uracil induced by protons and radiosensitization
Roy Chowdhury, Madhusree
CDW-EIS
DOUBLE DIFFERENTIAL CROSS SECTION
ELECTRON SPECTROSCOPY
FORWARD-BACKWARD ANGULAR ASYMMETRY
HALOURACILS
RADIOSENSITIZATION
title_short Electron emission from bromouracil and uracil induced by protons and radiosensitization
title_full Electron emission from bromouracil and uracil induced by protons and radiosensitization
title_fullStr Electron emission from bromouracil and uracil induced by protons and radiosensitization
title_full_unstemmed Electron emission from bromouracil and uracil induced by protons and radiosensitization
title_sort Electron emission from bromouracil and uracil induced by protons and radiosensitization
dc.creator.none.fl_str_mv Roy Chowdhury, Madhusree
Monti, Juan Manuel
Misra, Deepankar
Weck, Philippe F.
Rivarola, Roberto Daniel
Tribedi, Lokesh C.
author Roy Chowdhury, Madhusree
author_facet Roy Chowdhury, Madhusree
Monti, Juan Manuel
Misra, Deepankar
Weck, Philippe F.
Rivarola, Roberto Daniel
Tribedi, Lokesh C.
author_role author
author2 Monti, Juan Manuel
Misra, Deepankar
Weck, Philippe F.
Rivarola, Roberto Daniel
Tribedi, Lokesh C.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CDW-EIS
DOUBLE DIFFERENTIAL CROSS SECTION
ELECTRON SPECTROSCOPY
FORWARD-BACKWARD ANGULAR ASYMMETRY
HALOURACILS
RADIOSENSITIZATION
topic CDW-EIS
DOUBLE DIFFERENTIAL CROSS SECTION
ELECTRON SPECTROSCOPY
FORWARD-BACKWARD ANGULAR ASYMMETRY
HALOURACILS
RADIOSENSITIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Absolute double differential cross sections (DDCS) of electrons emitted from uracil and 5-bromouracil (BrU) in collisions with protons of energy 200 keV have been measured for various forward and backward emission angles over wide range of electron energies. The measured DDCS are compared with the continuum distorted wave-eikonal initial state (CDW-EIS) calculations. The optimized structure of the BrU was estimated along with the population analysis of all the occupied orbitals using a self-consistent field density. A comparison between the measured DDCS data for the two molecules show that the cross section of low energy electrons emitted from BrU is substantially larger than that for uracil. The BrU-to-uracil DDCS ratios obtained from the present measurements indicate an enhancement of the electron emission by a factor which is as large as 2.0 to 2.5. These electrons being the major agent for damaging the DNA/RNA of the malignant tissues, the present results are expected to provide an important input for the radiosensitization effect in hadron therapy. It is noteworthy to mention that the CDW-EIS calculations for Coulomb ionization cannot predict such enhancement. A large angular asymmetry is observed for uracil with a broad structure, which is absent in case of BrU.
Fil: Roy Chowdhury, Madhusree. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España
Fil: Monti, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Fil: Misra, Deepankar. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España
Fil: Weck, Philippe F.. No especifíca;
Fil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Fil: Tribedi, Lokesh C.. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España
description Absolute double differential cross sections (DDCS) of electrons emitted from uracil and 5-bromouracil (BrU) in collisions with protons of energy 200 keV have been measured for various forward and backward emission angles over wide range of electron energies. The measured DDCS are compared with the continuum distorted wave-eikonal initial state (CDW-EIS) calculations. The optimized structure of the BrU was estimated along with the population analysis of all the occupied orbitals using a self-consistent field density. A comparison between the measured DDCS data for the two molecules show that the cross section of low energy electrons emitted from BrU is substantially larger than that for uracil. The BrU-to-uracil DDCS ratios obtained from the present measurements indicate an enhancement of the electron emission by a factor which is as large as 2.0 to 2.5. These electrons being the major agent for damaging the DNA/RNA of the malignant tissues, the present results are expected to provide an important input for the radiosensitization effect in hadron therapy. It is noteworthy to mention that the CDW-EIS calculations for Coulomb ionization cannot predict such enhancement. A large angular asymmetry is observed for uracil with a broad structure, which is absent in case of BrU.
publishDate 2022
dc.date.none.fl_str_mv 2022-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/219148
Roy Chowdhury, Madhusree; Monti, Juan Manuel; Misra, Deepankar; Weck, Philippe F.; Rivarola, Roberto Daniel; et al.; Electron emission from bromouracil and uracil induced by protons and radiosensitization; IOP Publishing; New Journal of Physics; 24; 7; 7-2022; 1-11
1367-2630
CONICET Digital
CONICET
url http://hdl.handle.net/11336/219148
identifier_str_mv Roy Chowdhury, Madhusree; Monti, Juan Manuel; Misra, Deepankar; Weck, Philippe F.; Rivarola, Roberto Daniel; et al.; Electron emission from bromouracil and uracil induced by protons and radiosensitization; IOP Publishing; New Journal of Physics; 24; 7; 7-2022; 1-11
1367-2630
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1088/1367-2630/ac7e65
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOP Publishing
publisher.none.fl_str_mv IOP Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614185367896064
score 13.070432

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