Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs

Autores
Andrews, Steven S.; Peria, William J.; Yu, Richard C.; Colman Lerner, Alejandro Ariel; Brent, Roger
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Many cell signaling systems, including the yeast pheromone response system, exhibit “dose-response alignment” (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including “push-pull” mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control.
Fil: Andrews, Steven S.. Fred Hutchinson Cancer Research Center; Estados Unidos. The Molecular Sciences Institute; Estados Unidos
Fil: Peria, William J.. Fred Hutchinson Cancer Research Center; Estados Unidos
Fil: Yu, Richard C.. The Molecular Sciences Institute; Estados Unidos
Fil: Colman Lerner, Alejandro Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Brent, Roger. The Molecular Sciences Institute; Estados Unidos. Fred Hutchinson Cancer Research Center; Estados Unidos
Materia
Cell Signaling
Dose Response Alignment
Paradoxical Signaling
Pheromone Response System
Push-Pull
Saccharomyces Cervisiae
Yeast
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61391
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with InputsAndrews, Steven S.Peria, William J.Yu, Richard C.Colman Lerner, Alejandro ArielBrent, RogerCell SignalingDose Response AlignmentParadoxical SignalingPheromone Response SystemPush-PullSaccharomyces CervisiaeYeasthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Many cell signaling systems, including the yeast pheromone response system, exhibit “dose-response alignment” (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including “push-pull” mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control.Fil: Andrews, Steven S.. Fred Hutchinson Cancer Research Center; Estados Unidos. The Molecular Sciences Institute; Estados UnidosFil: Peria, William J.. Fred Hutchinson Cancer Research Center; Estados UnidosFil: Yu, Richard C.. The Molecular Sciences Institute; Estados UnidosFil: Colman Lerner, Alejandro Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Brent, Roger. The Molecular Sciences Institute; Estados Unidos. Fred Hutchinson Cancer Research Center; Estados UnidosCell Press2016-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61391Andrews, Steven S.; Peria, William J.; Yu, Richard C.; Colman Lerner, Alejandro Ariel; Brent, Roger; Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs; Cell Press; Cell Systems; 3; 5; 11-2016; 444-455.e22405-4720CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cels.2016.10.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2405471216303210info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:25Zoai:ri.conicet.gov.ar:11336/61391instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:25.31CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
title Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
spellingShingle Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
Andrews, Steven S.
Cell Signaling
Dose Response Alignment
Paradoxical Signaling
Pheromone Response System
Push-Pull
Saccharomyces Cervisiae
Yeast
title_short Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
title_full Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
title_fullStr Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
title_full_unstemmed Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
title_sort Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
dc.creator.none.fl_str_mv Andrews, Steven S.
Peria, William J.
Yu, Richard C.
Colman Lerner, Alejandro Ariel
Brent, Roger
author Andrews, Steven S.
author_facet Andrews, Steven S.
Peria, William J.
Yu, Richard C.
Colman Lerner, Alejandro Ariel
Brent, Roger
author_role author
author2 Peria, William J.
Yu, Richard C.
Colman Lerner, Alejandro Ariel
Brent, Roger
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cell Signaling
Dose Response Alignment
Paradoxical Signaling
Pheromone Response System
Push-Pull
Saccharomyces Cervisiae
Yeast
topic Cell Signaling
Dose Response Alignment
Paradoxical Signaling
Pheromone Response System
Push-Pull
Saccharomyces Cervisiae
Yeast
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Many cell signaling systems, including the yeast pheromone response system, exhibit “dose-response alignment” (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including “push-pull” mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control.
Fil: Andrews, Steven S.. Fred Hutchinson Cancer Research Center; Estados Unidos. The Molecular Sciences Institute; Estados Unidos
Fil: Peria, William J.. Fred Hutchinson Cancer Research Center; Estados Unidos
Fil: Yu, Richard C.. The Molecular Sciences Institute; Estados Unidos
Fil: Colman Lerner, Alejandro Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Brent, Roger. The Molecular Sciences Institute; Estados Unidos. Fred Hutchinson Cancer Research Center; Estados Unidos
description Many cell signaling systems, including the yeast pheromone response system, exhibit “dose-response alignment” (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including “push-pull” mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control.
publishDate 2016
dc.date.none.fl_str_mv 2016-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61391
Andrews, Steven S.; Peria, William J.; Yu, Richard C.; Colman Lerner, Alejandro Ariel; Brent, Roger; Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs; Cell Press; Cell Systems; 3; 5; 11-2016; 444-455.e2
2405-4720
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61391
identifier_str_mv Andrews, Steven S.; Peria, William J.; Yu, Richard C.; Colman Lerner, Alejandro Ariel; Brent, Roger; Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs; Cell Press; Cell Systems; 3; 5; 11-2016; 444-455.e2
2405-4720
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cels.2016.10.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2405471216303210
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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