Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

Autores
López, L.; Flichman, Diego Martin; Mojsiejczuk, Laura Noelia; Gonzalez, M. V.; Uriarte, R.; Campos, Rodolfo Hector; Cristina, J.; García Aguirre, L.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.
Fil: López, L.. Universidad de la República; Uruguay
Fil: Flichman, Diego Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mojsiejczuk, Laura Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gonzalez, M. V.. Centro Hospitalario Pereira Rossell. Departamento de Patología Clínica. Laboratorio de Inmunología; Uruguay
Fil: Uriarte, R.. Asociación Española. Laboratorio de Biología Molecular; Uruguay
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cristina, J.. Universidad de la República; Uruguay
Fil: García Aguirre, L.. Universidad de la República; Uruguay
Materia
Hepatitis B Virus
Genotypes Recombinants
Uruguay
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16024
Acceder
id CONICETDig_df6e6bb960324dba1fcba30f9b0a7fff
oai_identifier_str oai:ri.conicet.gov.ar:11336/16024
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinantsLópez, L.Flichman, Diego MartinMojsiejczuk, Laura NoeliaGonzalez, M. V.Uriarte, R.Campos, Rodolfo HectorCristina, J.García Aguirre, L.Hepatitis B VirusGenotypes RecombinantsUruguayhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.Fil: López, L.. Universidad de la República; UruguayFil: Flichman, Diego Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mojsiejczuk, Laura Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonzalez, M. V.. Centro Hospitalario Pereira Rossell. Departamento de Patología Clínica. Laboratorio de Inmunología; UruguayFil: Uriarte, R.. Asociación Española. Laboratorio de Biología Molecular; UruguayFil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cristina, J.. Universidad de la República; UruguayFil: García Aguirre, L.. Universidad de la República; UruguaySpringer Wien2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16024López, L.; Flichman, Diego Martin; Mojsiejczuk, Laura Noelia; Gonzalez, M. V.; Uriarte, R.; et al.; Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants; Springer Wien; Archives of Virology; 160; 9; 6-2015; 2209-22170304-86081432-8798enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-015-2477-0info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-015-2477-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:08Zoai:ri.conicet.gov.ar:11336/16024instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:08.239CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
title Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
spellingShingle Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
López, L.
Hepatitis B Virus
Genotypes Recombinants
Uruguay
title_short Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
title_full Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
title_fullStr Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
title_full_unstemmed Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
title_sort Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
dc.creator.none.fl_str_mv López, L.
Flichman, Diego Martin
Mojsiejczuk, Laura Noelia
Gonzalez, M. V.
Uriarte, R.
Campos, Rodolfo Hector
Cristina, J.
García Aguirre, L.
author López, L.
author_facet López, L.
Flichman, Diego Martin
Mojsiejczuk, Laura Noelia
Gonzalez, M. V.
Uriarte, R.
Campos, Rodolfo Hector
Cristina, J.
García Aguirre, L.
author_role author
author2 Flichman, Diego Martin
Mojsiejczuk, Laura Noelia
Gonzalez, M. V.
Uriarte, R.
Campos, Rodolfo Hector
Cristina, J.
García Aguirre, L.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hepatitis B Virus
Genotypes Recombinants
Uruguay
topic Hepatitis B Virus
Genotypes Recombinants
Uruguay
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.
Fil: López, L.. Universidad de la República; Uruguay
Fil: Flichman, Diego Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mojsiejczuk, Laura Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gonzalez, M. V.. Centro Hospitalario Pereira Rossell. Departamento de Patología Clínica. Laboratorio de Inmunología; Uruguay
Fil: Uriarte, R.. Asociación Española. Laboratorio de Biología Molecular; Uruguay
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cristina, J.. Universidad de la República; Uruguay
Fil: García Aguirre, L.. Universidad de la República; Uruguay
description Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16024
López, L.; Flichman, Diego Martin; Mojsiejczuk, Laura Noelia; Gonzalez, M. V.; Uriarte, R.; et al.; Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants; Springer Wien; Archives of Virology; 160; 9; 6-2015; 2209-2217
0304-8608
1432-8798
url http://hdl.handle.net/11336/16024
identifier_str_mv López, L.; Flichman, Diego Martin; Mojsiejczuk, Laura Noelia; Gonzalez, M. V.; Uriarte, R.; et al.; Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants; Springer Wien; Archives of Virology; 160; 9; 6-2015; 2209-2217
0304-8608
1432-8798
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-015-2477-0
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-015-2477-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Wien
publisher.none.fl_str_mv Springer Wien
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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