New limonene-hybrid derivatives with anti-T. cruzi activity

Autores
Alvarez, Guzmán; Gerpe, Alejandra; Benitez, Diego; Garibotto, Francisco Matías; Zacchino, Susana Alicia Stella; Graebin, Cedric Stephan; Gomes da Rosa, Ricardo; Eifler Lima, Vera; González, Mercedes; Cerecetto, Hugo
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycle-frameworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5-nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives. © 2010 Bentham Science Publishers Ltd.
Fil: Alvarez, Guzmán. Universidad de la República; Uruguay
Fil: Gerpe, Alejandra. Universidad de la República; Uruguay
Fil: Benitez, Diego. Universidad de la República; Uruguay
Fil: Garibotto, Francisco Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Graebin, Cedric Stephan. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gomes da Rosa, Ricardo. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Eifler Lima, Vera. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González, Mercedes. Universidad de la República; Uruguay
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Materia
LIMONENE DERIVATIVES
ANTI-T. CRUZI AGENTS
ANTIFUNGAL
LIPINSKI RULE
5-NITROFURAN
5-NITROINDAZOLE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125674
Acceder
id CONICETDig_df2f504c2c89ca0b04feb8b4a9e8164f
oai_identifier_str oai:ri.conicet.gov.ar:11336/125674
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New limonene-hybrid derivatives with anti-T. cruzi activityAlvarez, GuzmánGerpe, AlejandraBenitez, DiegoGaribotto, Francisco MatíasZacchino, Susana Alicia StellaGraebin, Cedric StephanGomes da Rosa, RicardoEifler Lima, VeraGonzález, MercedesCerecetto, HugoLIMONENE DERIVATIVESANTI-T. CRUZI AGENTSANTIFUNGALLIPINSKI RULE5-NITROFURAN5-NITROINDAZOLEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycle-frameworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5-nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives. © 2010 Bentham Science Publishers Ltd.Fil: Alvarez, Guzmán. Universidad de la República; UruguayFil: Gerpe, Alejandra. Universidad de la República; UruguayFil: Benitez, Diego. Universidad de la República; UruguayFil: Garibotto, Francisco Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Graebin, Cedric Stephan. Universidade Federal do Rio Grande do Sul; BrasilFil: Gomes da Rosa, Ricardo. Universidade Federal do Rio Grande do Sul; BrasilFil: Eifler Lima, Vera. Universidade Federal do Rio Grande do Sul; BrasilFil: González, Mercedes. Universidad de la República; UruguayFil: Cerecetto, Hugo. Universidad de la República; UruguayBentham Science Publishers2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125674Alvarez, Guzmán; Gerpe, Alejandra; Benitez, Diego; Garibotto, Francisco Matías; Zacchino, Susana Alicia Stella; et al.; New limonene-hybrid derivatives with anti-T. cruzi activity; Bentham Science Publishers; Letters In Drug Design & Discovery; 7; 6; 6-2010; 452-4601570-18081875-628XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/86250/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/157018010791306524info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:11:03Zoai:ri.conicet.gov.ar:11336/125674instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:11:03.97CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New limonene-hybrid derivatives with anti-T. cruzi activity
title New limonene-hybrid derivatives with anti-T. cruzi activity
spellingShingle New limonene-hybrid derivatives with anti-T. cruzi activity
Alvarez, Guzmán
LIMONENE DERIVATIVES
ANTI-T. CRUZI AGENTS
ANTIFUNGAL
LIPINSKI RULE
5-NITROFURAN
5-NITROINDAZOLE
title_short New limonene-hybrid derivatives with anti-T. cruzi activity
title_full New limonene-hybrid derivatives with anti-T. cruzi activity
title_fullStr New limonene-hybrid derivatives with anti-T. cruzi activity
title_full_unstemmed New limonene-hybrid derivatives with anti-T. cruzi activity
title_sort New limonene-hybrid derivatives with anti-T. cruzi activity
dc.creator.none.fl_str_mv Alvarez, Guzmán
Gerpe, Alejandra
Benitez, Diego
Garibotto, Francisco Matías
Zacchino, Susana Alicia Stella
Graebin, Cedric Stephan
Gomes da Rosa, Ricardo
Eifler Lima, Vera
González, Mercedes
Cerecetto, Hugo
author Alvarez, Guzmán
author_facet Alvarez, Guzmán
Gerpe, Alejandra
Benitez, Diego
Garibotto, Francisco Matías
Zacchino, Susana Alicia Stella
Graebin, Cedric Stephan
Gomes da Rosa, Ricardo
Eifler Lima, Vera
González, Mercedes
Cerecetto, Hugo
author_role author
author2 Gerpe, Alejandra
Benitez, Diego
Garibotto, Francisco Matías
Zacchino, Susana Alicia Stella
Graebin, Cedric Stephan
Gomes da Rosa, Ricardo
Eifler Lima, Vera
González, Mercedes
Cerecetto, Hugo
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LIMONENE DERIVATIVES
ANTI-T. CRUZI AGENTS
ANTIFUNGAL
LIPINSKI RULE
5-NITROFURAN
5-NITROINDAZOLE
topic LIMONENE DERIVATIVES
ANTI-T. CRUZI AGENTS
ANTIFUNGAL
LIPINSKI RULE
5-NITROFURAN
5-NITROINDAZOLE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycle-frameworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5-nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives. © 2010 Bentham Science Publishers Ltd.
Fil: Alvarez, Guzmán. Universidad de la República; Uruguay
Fil: Gerpe, Alejandra. Universidad de la República; Uruguay
Fil: Benitez, Diego. Universidad de la República; Uruguay
Fil: Garibotto, Francisco Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Graebin, Cedric Stephan. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gomes da Rosa, Ricardo. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Eifler Lima, Vera. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González, Mercedes. Universidad de la República; Uruguay
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
description The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycle-frameworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5-nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives. © 2010 Bentham Science Publishers Ltd.
publishDate 2010
dc.date.none.fl_str_mv 2010-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125674
Alvarez, Guzmán; Gerpe, Alejandra; Benitez, Diego; Garibotto, Francisco Matías; Zacchino, Susana Alicia Stella; et al.; New limonene-hybrid derivatives with anti-T. cruzi activity; Bentham Science Publishers; Letters In Drug Design & Discovery; 7; 6; 6-2010; 452-460
1570-1808
1875-628X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125674
identifier_str_mv Alvarez, Guzmán; Gerpe, Alejandra; Benitez, Diego; Garibotto, Francisco Matías; Zacchino, Susana Alicia Stella; et al.; New limonene-hybrid derivatives with anti-T. cruzi activity; Bentham Science Publishers; Letters In Drug Design & Discovery; 7; 6; 6-2010; 452-460
1570-1808
1875-628X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/86250/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/157018010791306524
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781481033138176
score 12.982451

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