Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

Autores: Morán, Ignasi; Akerman, Ildem; Van De Bunt, Martijn; Xie, Ruiyu; Benazra, Marion; Nammo, Takao; Arnes, Luis; Nakic, Nikolina; García Hurtado, Javier; Rodríguez Seguí, Santiago Andrés; Pasquali, Lorenzo; Sauty Colace, Claire; Beucher, Anthony; Scharfmann, Raphael; Van Arensbergen, Joris; Johnson, Paul R.; Berry, Andrew; Lee, Clarence; Harkins, Timothy; Gmyr, Valery; Pattou, François; Kerr Conte, Julie; Piemonti, Lorenzo; Berney, Thierry; Hanley, Neil; Gloyn, Anna L.; Sussel, Lori; Langman, Linda; Brayman, Kenneth L.; Sander, Maike; McCarthy, Mark I.; Ravassard, Philippe; Ferrer, Jorge
Año de publicación: 2012
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are an integral component of the β cell differentiation and maturation program. We sequenced the mouse islet transcriptome and identify lncRNA orthologs that are regulated like their human counterparts. Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. These findings reveal a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology.
Fil: Morán, Ignasi. Institut d’Investigacions Biomediques August Pi I Sunyer; España
Fil: Akerman, Ildem. Institut d’Investigacions Biomediques August Pi I Sunyer; España
Fil: Van De Bunt, Martijn. University of Oxford; Reino Unido. Churchill Hospital; Reino Unido
Fil: Xie, Ruiyu. University of California at San Diego; Estados Unidos
Fil: Benazra, Marion. Universite Pierre et Marie Curie; Francia
Fil: Nammo, Takao. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. National Center for Global Health and Medicine; Japón
Fil: Arnes, Luis. Columbia University; Estados Unidos
Fil: Nakic, Nikolina. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: García Hurtado, Javier. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pasquali, Lorenzo. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: Sauty Colace, Claire. Universite Pierre et Marie Curie; Francia
Fil: Beucher, Anthony. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: Scharfmann, Raphael. Inserm; Francia
Fil: Van Arensbergen, Joris. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: Johnson, Paul R.. Churchill Hospital; Reino Unido. John Radcliffe Hospital; Reino Unido
Fil: Berry, Andrew. University of Manchester; Reino Unido
Fil: Lee, Clarence. Life Technologies; Estados Unidos
Fil: Harkins, Timothy. Life Technologies; Estados Unidos
Fil: Gmyr, Valery. University of Lille Nord; Francia
Fil: Pattou, François. University of Lille Nord; Francia
Fil: Kerr Conte, Julie. University of Lille Nord; Francia
Fil: Piemonti, Lorenzo. San Raffaele Scientific Institute; Italia
Fil: Berney, Thierry. Cell Isolation and Transplantation Center; Suiza
Fil: Hanley, Neil. University of Manchester; Reino Unido
Fil: Gloyn, Anna L.. Churchill Hospital; Reino Unido
Fil: Sussel, Lori. Columbia University; Estados Unidos
Fil: Langman, Linda. University of Virginia; Estados Unidos
Fil: Brayman, Kenneth L.. University of Virginia; Estados Unidos
Fil: Sander, Maike. University of California at San Diego; Estados Unidos
Fil: McCarthy, Mark I.. Churchill Hospital; Reino Unido. University of Oxford; Reino Unido. San Raffaele Scientific Institute; Italia
Fil: Ravassard, Philippe. Universite Pierre et Marie Curie; Francia
Fil: Ferrer, Jorge. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic de Barcelona; España
Materia: Beta Cell
Pancreas
Noncoding Rna
Diabetes
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/68501

Acceder

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network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetesMorán, IgnasiAkerman, IldemVan De Bunt, MartijnXie, RuiyuBenazra, MarionNammo, TakaoArnes, LuisNakic, NikolinaGarcía Hurtado, JavierRodríguez Seguí, Santiago AndrésPasquali, LorenzoSauty Colace, ClaireBeucher, AnthonyScharfmann, RaphaelVan Arensbergen, JorisJohnson, Paul R.Berry, AndrewLee, ClarenceHarkins, TimothyGmyr, ValeryPattou, FrançoisKerr Conte, JuliePiemonti, LorenzoBerney, ThierryHanley, NeilGloyn, Anna L.Sussel, LoriLangman, LindaBrayman, Kenneth L.Sander, MaikeMcCarthy, Mark I.Ravassard, PhilippeFerrer, JorgeBeta CellPancreasNoncoding RnaDiabeteshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are an integral component of the β cell differentiation and maturation program. We sequenced the mouse islet transcriptome and identify lncRNA orthologs that are regulated like their human counterparts. Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. These findings reveal a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology.Fil: Morán, Ignasi. Institut d’Investigacions Biomediques August Pi I Sunyer; EspañaFil: Akerman, Ildem. Institut d’Investigacions Biomediques August Pi I Sunyer; EspañaFil: Van De Bunt, Martijn. University of Oxford; Reino Unido. Churchill Hospital; Reino UnidoFil: Xie, Ruiyu. University of California at San Diego; Estados UnidosFil: Benazra, Marion. Universite Pierre et Marie Curie; FranciaFil: Nammo, Takao. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. National Center for Global Health and Medicine; JapónFil: Arnes, Luis. Columbia University; Estados UnidosFil: Nakic, Nikolina. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: García Hurtado, Javier. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pasquali, Lorenzo. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: Sauty Colace, Claire. Universite Pierre et Marie Curie; FranciaFil: Beucher, Anthony. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: Scharfmann, Raphael. Inserm; FranciaFil: Van Arensbergen, Joris. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: Johnson, Paul R.. Churchill Hospital; Reino Unido. John Radcliffe Hospital; Reino UnidoFil: Berry, Andrew. University of Manchester; Reino UnidoFil: Lee, Clarence. Life Technologies; Estados UnidosFil: Harkins, Timothy. Life Technologies; Estados UnidosFil: Gmyr, Valery. University of Lille Nord; FranciaFil: Pattou, François. University of Lille Nord; FranciaFil: Kerr Conte, Julie. University of Lille Nord; FranciaFil: Piemonti, Lorenzo. San Raffaele Scientific Institute; ItaliaFil: Berney, Thierry. Cell Isolation and Transplantation Center; SuizaFil: Hanley, Neil. University of Manchester; Reino UnidoFil: Gloyn, Anna L.. Churchill Hospital; Reino UnidoFil: Sussel, Lori. Columbia University; Estados UnidosFil: Langman, Linda. University of Virginia; Estados UnidosFil: Brayman, Kenneth L.. University of Virginia; Estados UnidosFil: Sander, Maike. University of California at San Diego; Estados UnidosFil: McCarthy, Mark I.. Churchill Hospital; Reino Unido. University of Oxford; Reino Unido. San Raffaele Scientific Institute; ItaliaFil: Ravassard, Philippe. Universite Pierre et Marie Curie; FranciaFil: Ferrer, Jorge. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic de Barcelona; EspañaCell Press2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/68501Morán, Ignasi; Akerman, Ildem; Van De Bunt, Martijn; Xie, Ruiyu; Benazra, Marion; et al.; Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes; Cell Press; Cell Metabolism; 16; 4; 10-2012; 435-4481550-4131CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cmet.2012.08.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1550413112003610info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:11Zoai:ri.conicet.gov.ar:11336/68501instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:11.398CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
title	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
spellingShingle	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes Morán, Ignasi Beta Cell Pancreas Noncoding Rna Diabetes
title_short	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
title_full	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
title_fullStr	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
title_full_unstemmed	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
title_sort	Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
dc.creator.none.fl_str_mv	Morán, Ignasi Akerman, Ildem Van De Bunt, Martijn Xie, Ruiyu Benazra, Marion Nammo, Takao Arnes, Luis Nakic, Nikolina García Hurtado, Javier Rodríguez Seguí, Santiago Andrés Pasquali, Lorenzo Sauty Colace, Claire Beucher, Anthony Scharfmann, Raphael Van Arensbergen, Joris Johnson, Paul R. Berry, Andrew Lee, Clarence Harkins, Timothy Gmyr, Valery Pattou, François Kerr Conte, Julie Piemonti, Lorenzo Berney, Thierry Hanley, Neil Gloyn, Anna L. Sussel, Lori Langman, Linda Brayman, Kenneth L. Sander, Maike McCarthy, Mark I. Ravassard, Philippe Ferrer, Jorge
author	Morán, Ignasi
author_facet	Morán, Ignasi Akerman, Ildem Van De Bunt, Martijn Xie, Ruiyu Benazra, Marion Nammo, Takao Arnes, Luis Nakic, Nikolina García Hurtado, Javier Rodríguez Seguí, Santiago Andrés Pasquali, Lorenzo Sauty Colace, Claire Beucher, Anthony Scharfmann, Raphael Van Arensbergen, Joris Johnson, Paul R. Berry, Andrew Lee, Clarence Harkins, Timothy Gmyr, Valery Pattou, François Kerr Conte, Julie Piemonti, Lorenzo Berney, Thierry Hanley, Neil Gloyn, Anna L. Sussel, Lori Langman, Linda Brayman, Kenneth L. Sander, Maike McCarthy, Mark I. Ravassard, Philippe Ferrer, Jorge
author_role	author
author2	Akerman, Ildem Van De Bunt, Martijn Xie, Ruiyu Benazra, Marion Nammo, Takao Arnes, Luis Nakic, Nikolina García Hurtado, Javier Rodríguez Seguí, Santiago Andrés Pasquali, Lorenzo Sauty Colace, Claire Beucher, Anthony Scharfmann, Raphael Van Arensbergen, Joris Johnson, Paul R. Berry, Andrew Lee, Clarence Harkins, Timothy Gmyr, Valery Pattou, François Kerr Conte, Julie Piemonti, Lorenzo Berney, Thierry Hanley, Neil Gloyn, Anna L. Sussel, Lori Langman, Linda Brayman, Kenneth L. Sander, Maike McCarthy, Mark I. Ravassard, Philippe Ferrer, Jorge
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Beta Cell Pancreas Noncoding Rna Diabetes
topic	Beta Cell Pancreas Noncoding Rna Diabetes
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are an integral component of the β cell differentiation and maturation program. We sequenced the mouse islet transcriptome and identify lncRNA orthologs that are regulated like their human counterparts. Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. These findings reveal a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology. Fil: Morán, Ignasi. Institut d’Investigacions Biomediques August Pi I Sunyer; España Fil: Akerman, Ildem. Institut d’Investigacions Biomediques August Pi I Sunyer; España Fil: Van De Bunt, Martijn. University of Oxford; Reino Unido. Churchill Hospital; Reino Unido Fil: Xie, Ruiyu. University of California at San Diego; Estados Unidos Fil: Benazra, Marion. Universite Pierre et Marie Curie; Francia Fil: Nammo, Takao. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. National Center for Global Health and Medicine; Japón Fil: Arnes, Luis. Columbia University; Estados Unidos Fil: Nakic, Nikolina. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España Fil: García Hurtado, Javier. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pasquali, Lorenzo. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España Fil: Sauty Colace, Claire. Universite Pierre et Marie Curie; Francia Fil: Beucher, Anthony. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España Fil: Scharfmann, Raphael. Inserm; Francia Fil: Van Arensbergen, Joris. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España Fil: Johnson, Paul R.. Churchill Hospital; Reino Unido. John Radcliffe Hospital; Reino Unido Fil: Berry, Andrew. University of Manchester; Reino Unido Fil: Lee, Clarence. Life Technologies; Estados Unidos Fil: Harkins, Timothy. Life Technologies; Estados Unidos Fil: Gmyr, Valery. University of Lille Nord; Francia Fil: Pattou, François. University of Lille Nord; Francia Fil: Kerr Conte, Julie. University of Lille Nord; Francia Fil: Piemonti, Lorenzo. San Raffaele Scientific Institute; Italia Fil: Berney, Thierry. Cell Isolation and Transplantation Center; Suiza Fil: Hanley, Neil. University of Manchester; Reino Unido Fil: Gloyn, Anna L.. Churchill Hospital; Reino Unido Fil: Sussel, Lori. Columbia University; Estados Unidos Fil: Langman, Linda. University of Virginia; Estados Unidos Fil: Brayman, Kenneth L.. University of Virginia; Estados Unidos Fil: Sander, Maike. University of California at San Diego; Estados Unidos Fil: McCarthy, Mark I.. Churchill Hospital; Reino Unido. University of Oxford; Reino Unido. San Raffaele Scientific Institute; Italia Fil: Ravassard, Philippe. Universite Pierre et Marie Curie; Francia Fil: Ferrer, Jorge. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic de Barcelona; España
description	A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are an integral component of the β cell differentiation and maturation program. We sequenced the mouse islet transcriptome and identify lncRNA orthologs that are regulated like their human counterparts. Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. These findings reveal a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology.
publishDate	2012
dc.date.none.fl_str_mv	2012-10
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/68501 Morán, Ignasi; Akerman, Ildem; Van De Bunt, Martijn; Xie, Ruiyu; Benazra, Marion; et al.; Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes; Cell Press; Cell Metabolism; 16; 4; 10-2012; 435-448 1550-4131 CONICET Digital CONICET
url	http://hdl.handle.net/11336/68501
identifier_str_mv	Morán, Ignasi; Akerman, Ildem; Van De Bunt, Martijn; Xie, Ruiyu; Benazra, Marion; et al.; Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes; Cell Press; Cell Metabolism; 16; 4; 10-2012; 435-448 1550-4131 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cmet.2012.08.010 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1550413112003610
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Cell Press
publisher.none.fl_str_mv	Cell Press
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.070432

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

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