Screening for primary aldosteronism in an argentinian population: a multicenter prospective study

Autores
Leal Reyna, Mariela; Gomez, Reynaldo Manuel; Lupi, Susana N.; Belli, Susana H.; Fenili, Cecilia A.; Martínez, Marcela S.; Ruibal, Gabriela F.; Rossi, María A; Chervin, Raúl A; Cornaló, Dora; Contreras, Liliana Noemí; Costa, Liliana; Nofal, María T.; Damilano, Sergio A.; Pardes, Ester M.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVES:Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study.SUBJECTS AND METHODS:We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined.RESULTS:According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively.CONCLUSION:This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.
Fil: Leal Reyna, Mariela. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; Argentina
Fil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Lupi, Susana N.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Belli, Susana H.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Durand; Argentina
Fil: Fenili, Cecilia A.. Gobierno de la Ciudad Autónoma de Buenos Aires. Laboratorio Bioanalítica; Argentina
Fil: Martínez, Marcela S.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Milstein; Argentina
Fil: Ruibal, Gabriela F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Rossi, María A. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; Argentina
Fil: Chervin, Raúl A. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cornaló, Dora. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital B. Rivadavia; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Costa, Liliana. Gobierno de la Provincia de Buenos Aires. Hospital Nacional “Profesor Alejandro Posadas” ; Argentina
Fil: Nofal, María T.. Clínica Bazterrica; Argentina
Fil: Damilano, Sergio A.. Laboratorio Bioanalítica; Argentina
Fil: Pardes, Ester M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Materia
PRIMARY ALDOSTERONISM
ALDOSTERONE
HYPERTENSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42343
Acceder
id CONICETDig_de9f8c7a8d666968b174af9180ba2027
oai_identifier_str oai:ri.conicet.gov.ar:11336/42343
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Screening for primary aldosteronism in an argentinian population: a multicenter prospective studyLeal Reyna, MarielaGomez, Reynaldo ManuelLupi, Susana N.Belli, Susana H.Fenili, Cecilia A.Martínez, Marcela S.Ruibal, Gabriela F.Rossi, María AChervin, Raúl ACornaló, DoraContreras, Liliana NoemíCosta, LilianaNofal, María T.Damilano, Sergio A.Pardes, Ester M.PRIMARY ALDOSTERONISMALDOSTERONEHYPERTENSIONhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3OBJECTIVES:Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study.SUBJECTS AND METHODS:We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined.RESULTS:According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively.CONCLUSION:This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.Fil: Leal Reyna, Mariela. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; ArgentinaFil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Lupi, Susana N.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Belli, Susana H.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Durand; ArgentinaFil: Fenili, Cecilia A.. Gobierno de la Ciudad Autónoma de Buenos Aires. Laboratorio Bioanalítica; ArgentinaFil: Martínez, Marcela S.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Milstein; ArgentinaFil: Ruibal, Gabriela F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Rossi, María A. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; ArgentinaFil: Chervin, Raúl A. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Cornaló, Dora. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital B. Rivadavia; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Costa, Liliana. Gobierno de la Provincia de Buenos Aires. Hospital Nacional “Profesor Alejandro Posadas” ; ArgentinaFil: Nofal, María T.. Clínica Bazterrica; ArgentinaFil: Damilano, Sergio A.. Laboratorio Bioanalítica; ArgentinaFil: Pardes, Ester M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaSP SegmentoFarma Editores2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/42343Leal Reyna, Mariela; Gomez, Reynaldo Manuel; Lupi, Susana N.; Belli, Susana H.; Fenili, Cecilia A.; et al.; Screening for primary aldosteronism in an argentinian population: a multicenter prospective study; SP SegmentoFarma Editores; Archives of Endocrinology and Metabolism; 59; 5; 10-2015; 441-4472359-39972359-4292CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/mjqbzfinfo:eu-repo/semantics/altIdentifier/doi/10.1590/2359-3997000000075info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:05Zoai:ri.conicet.gov.ar:11336/42343instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:05.351CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
title Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
spellingShingle Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
Leal Reyna, Mariela
PRIMARY ALDOSTERONISM
ALDOSTERONE
HYPERTENSION
title_short Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
title_full Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
title_fullStr Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
title_full_unstemmed Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
title_sort Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
dc.creator.none.fl_str_mv Leal Reyna, Mariela
Gomez, Reynaldo Manuel
Lupi, Susana N.
Belli, Susana H.
Fenili, Cecilia A.
Martínez, Marcela S.
Ruibal, Gabriela F.
Rossi, María A
Chervin, Raúl A
Cornaló, Dora
Contreras, Liliana Noemí
Costa, Liliana
Nofal, María T.
Damilano, Sergio A.
Pardes, Ester M.
author Leal Reyna, Mariela
author_facet Leal Reyna, Mariela
Gomez, Reynaldo Manuel
Lupi, Susana N.
Belli, Susana H.
Fenili, Cecilia A.
Martínez, Marcela S.
Ruibal, Gabriela F.
Rossi, María A
Chervin, Raúl A
Cornaló, Dora
Contreras, Liliana Noemí
Costa, Liliana
Nofal, María T.
Damilano, Sergio A.
Pardes, Ester M.
author_role author
author2 Gomez, Reynaldo Manuel
Lupi, Susana N.
Belli, Susana H.
Fenili, Cecilia A.
Martínez, Marcela S.
Ruibal, Gabriela F.
Rossi, María A
Chervin, Raúl A
Cornaló, Dora
Contreras, Liliana Noemí
Costa, Liliana
Nofal, María T.
Damilano, Sergio A.
Pardes, Ester M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PRIMARY ALDOSTERONISM
ALDOSTERONE
HYPERTENSION
topic PRIMARY ALDOSTERONISM
ALDOSTERONE
HYPERTENSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVES:Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study.SUBJECTS AND METHODS:We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined.RESULTS:According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively.CONCLUSION:This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.
Fil: Leal Reyna, Mariela. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; Argentina
Fil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Lupi, Susana N.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Belli, Susana H.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Durand; Argentina
Fil: Fenili, Cecilia A.. Gobierno de la Ciudad Autónoma de Buenos Aires. Laboratorio Bioanalítica; Argentina
Fil: Martínez, Marcela S.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Milstein; Argentina
Fil: Ruibal, Gabriela F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Rossi, María A. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; Argentina
Fil: Chervin, Raúl A. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cornaló, Dora. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital B. Rivadavia; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Costa, Liliana. Gobierno de la Provincia de Buenos Aires. Hospital Nacional “Profesor Alejandro Posadas” ; Argentina
Fil: Nofal, María T.. Clínica Bazterrica; Argentina
Fil: Damilano, Sergio A.. Laboratorio Bioanalítica; Argentina
Fil: Pardes, Ester M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
description OBJECTIVES:Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study.SUBJECTS AND METHODS:We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined.RESULTS:According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively.CONCLUSION:This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42343
Leal Reyna, Mariela; Gomez, Reynaldo Manuel; Lupi, Susana N.; Belli, Susana H.; Fenili, Cecilia A.; et al.; Screening for primary aldosteronism in an argentinian population: a multicenter prospective study; SP SegmentoFarma Editores; Archives of Endocrinology and Metabolism; 59; 5; 10-2015; 441-447
2359-3997
2359-4292
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42343
identifier_str_mv Leal Reyna, Mariela; Gomez, Reynaldo Manuel; Lupi, Susana N.; Belli, Susana H.; Fenili, Cecilia A.; et al.; Screening for primary aldosteronism in an argentinian population: a multicenter prospective study; SP SegmentoFarma Editores; Archives of Endocrinology and Metabolism; 59; 5; 10-2015; 441-447
2359-3997
2359-4292
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/mjqbzf
info:eu-repo/semantics/altIdentifier/doi/10.1590/2359-3997000000075
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv SP SegmentoFarma Editores
publisher.none.fl_str_mv SP SegmentoFarma Editores
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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