The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis

Autores
Castillo, Ana Fernanda; Orlando, Ulises Daniel; Helfenberger, Katia E.; Poderoso, Cecilia; Podesta, Ernesto Jorge
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity.
Fil: Castillo, Ana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Orlando, Ulises Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Helfenberger, Katia E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Poderoso, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Podesta, Ernesto Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Materia
Steroidogenic Acute Regulatory Protein
Mitochondrial Membranes
Cholesterol Transport
Phosphorylation
Erk-Dependent Star Phosphorylation
Mitochondrial Dynamics
Mitochondrial Phosphatases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15216
Acceder
id CONICETDig_de51827ebdbb817296677f2716d59e28
oai_identifier_str oai:ri.conicet.gov.ar:11336/15216
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesisCastillo, Ana FernandaOrlando, Ulises DanielHelfenberger, Katia E.Poderoso, CeciliaPodesta, Ernesto JorgeSteroidogenic Acute Regulatory ProteinMitochondrial MembranesCholesterol TransportPhosphorylationErk-Dependent Star PhosphorylationMitochondrial DynamicsMitochondrial Phosphataseshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity.Fil: Castillo, Ana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; ArgentinaFil: Orlando, Ulises Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; ArgentinaFil: Helfenberger, Katia E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; ArgentinaFil: Poderoso, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; ArgentinaFil: Podesta, Ernesto Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; ArgentinaElsevier Ireland2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15216Castillo, Ana Fernanda; Orlando, Ulises Daniel; Helfenberger, Katia E.; Poderoso, Cecilia; Podesta, Ernesto Jorge; The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis; Elsevier Ireland; Molecular and Cellular Endocrinology; 408; 6-2015; 73-790303-7207enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720714004134info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2014.12.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:59:06Zoai:ri.conicet.gov.ar:11336/15216instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:59:06.763CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
title The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
spellingShingle The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
Castillo, Ana Fernanda
Steroidogenic Acute Regulatory Protein
Mitochondrial Membranes
Cholesterol Transport
Phosphorylation
Erk-Dependent Star Phosphorylation
Mitochondrial Dynamics
Mitochondrial Phosphatases
title_short The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
title_full The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
title_fullStr The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
title_full_unstemmed The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
title_sort The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
dc.creator.none.fl_str_mv Castillo, Ana Fernanda
Orlando, Ulises Daniel
Helfenberger, Katia E.
Poderoso, Cecilia
Podesta, Ernesto Jorge
author Castillo, Ana Fernanda
author_facet Castillo, Ana Fernanda
Orlando, Ulises Daniel
Helfenberger, Katia E.
Poderoso, Cecilia
Podesta, Ernesto Jorge
author_role author
author2 Orlando, Ulises Daniel
Helfenberger, Katia E.
Poderoso, Cecilia
Podesta, Ernesto Jorge
author2_role author
author
author
author
dc.subject.none.fl_str_mv Steroidogenic Acute Regulatory Protein
Mitochondrial Membranes
Cholesterol Transport
Phosphorylation
Erk-Dependent Star Phosphorylation
Mitochondrial Dynamics
Mitochondrial Phosphatases
topic Steroidogenic Acute Regulatory Protein
Mitochondrial Membranes
Cholesterol Transport
Phosphorylation
Erk-Dependent Star Phosphorylation
Mitochondrial Dynamics
Mitochondrial Phosphatases
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity.
Fil: Castillo, Ana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Orlando, Ulises Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Helfenberger, Katia E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Poderoso, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
Fil: Podesta, Ernesto Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquimica; Argentina
description The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15216
Castillo, Ana Fernanda; Orlando, Ulises Daniel; Helfenberger, Katia E.; Poderoso, Cecilia; Podesta, Ernesto Jorge; The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis; Elsevier Ireland; Molecular and Cellular Endocrinology; 408; 6-2015; 73-79
0303-7207
url http://hdl.handle.net/11336/15216
identifier_str_mv Castillo, Ana Fernanda; Orlando, Ulises Daniel; Helfenberger, Katia E.; Poderoso, Cecilia; Podesta, Ernesto Jorge; The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis; Elsevier Ireland; Molecular and Cellular Endocrinology; 408; 6-2015; 73-79
0303-7207
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720714004134
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2014.12.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606934897295360
score 13.001348

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