First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America

Autores
Isla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; Vivot, Walter Oscar; Szusz, Wanda; Córdoba, Susana Beatríz; García Effron, Guillermo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
One of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.
Fil: Isla, Guillermina. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Leonardelli, Florencia. Universidad Nacional del Litoral; Argentina
Fil: Tiraboschi, Iris Nora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Refojo, Nicolás. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Hevia, Alejandra. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Vivot, Walter Oscar. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Szusz, Wanda. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Córdoba, Susana Beatríz. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Effron, Guillermo. Instituto Nacional de Enfermedades Infecciosas; Argentina
Materia
ASPERGILLUS FUMIGATUS
AZOLE
CYP51A
RESISTANCE
SOUTH AMERICA
TR46
TR46 Y121F T289A MUTATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89641
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/89641
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South AmericaIsla, GuillerminaLeonardelli, FlorenciaTiraboschi, Iris NoraRefojo, NicolásHevia, AlejandraVivot, Walter OscarSzusz, WandaCórdoba, Susana BeatrízGarcía Effron, GuillermoASPERGILLUS FUMIGATUSAZOLECYP51ARESISTANCESOUTH AMERICATR46TR46 Y121F T289A MUTATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1One of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.Fil: Isla, Guillermina. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Leonardelli, Florencia. Universidad Nacional del Litoral; ArgentinaFil: Tiraboschi, Iris Nora. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Refojo, Nicolás. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Hevia, Alejandra. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Vivot, Walter Oscar. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Szusz, Wanda. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Córdoba, Susana Beatríz. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: García Effron, Guillermo. Instituto Nacional de Enfermedades Infecciosas; ArgentinaAmerican Society for Microbiology2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89641Isla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; et al.; First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 10; 10-2018; 1-70066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/lookup/doi/10.1128/AAC.00872-18info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00872-18info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:46Zoai:ri.conicet.gov.ar:11336/89641instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:46.643CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
title First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
spellingShingle First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
Isla, Guillermina
ASPERGILLUS FUMIGATUS
AZOLE
CYP51A
RESISTANCE
SOUTH AMERICA
TR46
TR46 Y121F T289A MUTATION
title_short First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
title_full First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
title_fullStr First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
title_full_unstemmed First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
title_sort First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
dc.creator.none.fl_str_mv Isla, Guillermina
Leonardelli, Florencia
Tiraboschi, Iris Nora
Refojo, Nicolás
Hevia, Alejandra
Vivot, Walter Oscar
Szusz, Wanda
Córdoba, Susana Beatríz
García Effron, Guillermo
author Isla, Guillermina
author_facet Isla, Guillermina
Leonardelli, Florencia
Tiraboschi, Iris Nora
Refojo, Nicolás
Hevia, Alejandra
Vivot, Walter Oscar
Szusz, Wanda
Córdoba, Susana Beatríz
García Effron, Guillermo
author_role author
author2 Leonardelli, Florencia
Tiraboschi, Iris Nora
Refojo, Nicolás
Hevia, Alejandra
Vivot, Walter Oscar
Szusz, Wanda
Córdoba, Susana Beatríz
García Effron, Guillermo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ASPERGILLUS FUMIGATUS
AZOLE
CYP51A
RESISTANCE
SOUTH AMERICA
TR46
TR46 Y121F T289A MUTATION
topic ASPERGILLUS FUMIGATUS
AZOLE
CYP51A
RESISTANCE
SOUTH AMERICA
TR46
TR46 Y121F T289A MUTATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv One of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.
Fil: Isla, Guillermina. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Leonardelli, Florencia. Universidad Nacional del Litoral; Argentina
Fil: Tiraboschi, Iris Nora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Refojo, Nicolás. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Hevia, Alejandra. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Vivot, Walter Oscar. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Szusz, Wanda. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Córdoba, Susana Beatríz. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Effron, Guillermo. Instituto Nacional de Enfermedades Infecciosas; Argentina
description One of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89641
Isla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; et al.; First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 10; 10-2018; 1-7
0066-4804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89641
identifier_str_mv Isla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; et al.; First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 10; 10-2018; 1-7
0066-4804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/lookup/doi/10.1128/AAC.00872-18
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00872-18
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613617223204864
score 13.070432

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