Joint fitting reveals hidden interactions in tumor growth

Autores
Barberis, Lucas Miguel; Pasquale, Miguel Angel; Condat, Carlos
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Crucial to the system evolution are the interactions between these populations. To obtain information about these interactions we apply the recently developed vector universality (VUN) formalism to various instances of competition between tumor populations. The formalism allows us (a) to quantify the growth mechanisms of a HeLa cell colony, describing the phenotype switching responsible for its fast expansion, (b) to reliably reconstruct the evolution of the necrotic and viable fractions in both in vitro and in vivo tumors using data for the time dependences of the total masses alone, and (c) to show how the shedding of cells leading to sub-spheroid formation is beneficial to both the spheroid and sub-spheroid populations, suggesting that shedding is a strong positive influence on cancer dissemination.
Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Física de Líquidos y Sistemas Biológicos (i); Argentina. Université de Nice Sophia Antipolis; Francia
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Condat, Carlos. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Física "Enrique Gaviola"; Argentina
Materia
CANCER POPULATIONS
UNIVERSALITIES
SPHEROIDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5461
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Joint fitting reveals hidden interactions in tumor growthBarberis, Lucas MiguelPasquale, Miguel AngelCondat, CarlosCANCER POPULATIONSUNIVERSALITIESSPHEROIDShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Crucial to the system evolution are the interactions between these populations. To obtain information about these interactions we apply the recently developed vector universality (VUN) formalism to various instances of competition between tumor populations. The formalism allows us (a) to quantify the growth mechanisms of a HeLa cell colony, describing the phenotype switching responsible for its fast expansion, (b) to reliably reconstruct the evolution of the necrotic and viable fractions in both in vitro and in vivo tumors using data for the time dependences of the total masses alone, and (c) to show how the shedding of cells leading to sub-spheroid formation is beneficial to both the spheroid and sub-spheroid populations, suggesting that shedding is a strong positive influence on cancer dissemination.Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Física de Líquidos y Sistemas Biológicos (i); Argentina. Université de Nice Sophia Antipolis; FranciaFil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Condat, Carlos. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Física "Enrique Gaviola"; ArgentinaElsevier2014-11-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5461Barberis, Lucas Miguel; Pasquale, Miguel Angel; Condat, Carlos; Joint fitting reveals hidden interactions in tumor growth; Elsevier; Journal of Theoretical Biology; 365; 11-11-2014; 420-4320022-5193enginfo:eu-repo/semantics/altIdentifier/arxiv/1403.7161v1info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022519314006286info:eu-repo/semantics/altIdentifier/url/http://arxiv.org/abs/1403.7161v1info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2014.10.038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:20Zoai:ri.conicet.gov.ar:11336/5461instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:20.962CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Joint fitting reveals hidden interactions in tumor growth
title Joint fitting reveals hidden interactions in tumor growth
spellingShingle Joint fitting reveals hidden interactions in tumor growth
Barberis, Lucas Miguel
CANCER POPULATIONS
UNIVERSALITIES
SPHEROIDS
title_short Joint fitting reveals hidden interactions in tumor growth
title_full Joint fitting reveals hidden interactions in tumor growth
title_fullStr Joint fitting reveals hidden interactions in tumor growth
title_full_unstemmed Joint fitting reveals hidden interactions in tumor growth
title_sort Joint fitting reveals hidden interactions in tumor growth
dc.creator.none.fl_str_mv Barberis, Lucas Miguel
Pasquale, Miguel Angel
Condat, Carlos
author Barberis, Lucas Miguel
author_facet Barberis, Lucas Miguel
Pasquale, Miguel Angel
Condat, Carlos
author_role author
author2 Pasquale, Miguel Angel
Condat, Carlos
author2_role author
author
dc.subject.none.fl_str_mv CANCER POPULATIONS
UNIVERSALITIES
SPHEROIDS
topic CANCER POPULATIONS
UNIVERSALITIES
SPHEROIDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Crucial to the system evolution are the interactions between these populations. To obtain information about these interactions we apply the recently developed vector universality (VUN) formalism to various instances of competition between tumor populations. The formalism allows us (a) to quantify the growth mechanisms of a HeLa cell colony, describing the phenotype switching responsible for its fast expansion, (b) to reliably reconstruct the evolution of the necrotic and viable fractions in both in vitro and in vivo tumors using data for the time dependences of the total masses alone, and (c) to show how the shedding of cells leading to sub-spheroid formation is beneficial to both the spheroid and sub-spheroid populations, suggesting that shedding is a strong positive influence on cancer dissemination.
Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Física de Líquidos y Sistemas Biológicos (i); Argentina. Université de Nice Sophia Antipolis; Francia
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Condat, Carlos. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Física "Enrique Gaviola"; Argentina
description Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Crucial to the system evolution are the interactions between these populations. To obtain information about these interactions we apply the recently developed vector universality (VUN) formalism to various instances of competition between tumor populations. The formalism allows us (a) to quantify the growth mechanisms of a HeLa cell colony, describing the phenotype switching responsible for its fast expansion, (b) to reliably reconstruct the evolution of the necrotic and viable fractions in both in vitro and in vivo tumors using data for the time dependences of the total masses alone, and (c) to show how the shedding of cells leading to sub-spheroid formation is beneficial to both the spheroid and sub-spheroid populations, suggesting that shedding is a strong positive influence on cancer dissemination.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5461
Barberis, Lucas Miguel; Pasquale, Miguel Angel; Condat, Carlos; Joint fitting reveals hidden interactions in tumor growth; Elsevier; Journal of Theoretical Biology; 365; 11-11-2014; 420-432
0022-5193
url http://hdl.handle.net/11336/5461
identifier_str_mv Barberis, Lucas Miguel; Pasquale, Miguel Angel; Condat, Carlos; Joint fitting reveals hidden interactions in tumor growth; Elsevier; Journal of Theoretical Biology; 365; 11-11-2014; 420-432
0022-5193
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/arxiv/1403.7161v1
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022519314006286
info:eu-repo/semantics/altIdentifier/url/http://arxiv.org/abs/1403.7161v1
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2014.10.038
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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