Melatonin and Human Cardiovascular Disease

Autores
Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Ojike, Nwakile I.; Akinseye, Oluwaseun A.; Kendzerska, Tetyana; Buttoo, Kenneth; Dhandapany, Perundurai S.; Brown, Gregory M.; Cardinali, Daniel Pedro
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.
Fil: Pandi Perumal, Seithikurippu R.. King Saud University; Arabia Saudita
Fil: BaHammam, Ahmed S.. King Saud University; Arabia Saudita
Fil: Ojike, Nwakile I.. King Saud University; Arabia Saudita
Fil: Akinseye, Oluwaseun A.. University of New York; Estados Unidos
Fil: Kendzerska, Tetyana. Sunnybrook Health Sciences Center; Canadá
Fil: Buttoo, Kenneth. Sleep Disorders Center; Canadá
Fil: Dhandapany, Perundurai S.. Oregon Health And Science University; Estados Unidos
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina ; Argentina
Materia
blood pressure
cardioprotection
cardiovascular disorders
coronary artery disease
hypertension
melatonin
platelets
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47960
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47960
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Melatonin and Human Cardiovascular DiseasePandi Perumal, Seithikurippu R.BaHammam, Ahmed S.Ojike, Nwakile I.Akinseye, Oluwaseun A.Kendzerska, TetyanaButtoo, KennethDhandapany, Perundurai S.Brown, Gregory M.Cardinali, Daniel Pedroblood pressurecardioprotectioncardiovascular disorderscoronary artery diseasehypertensionmelatoninplateletshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.Fil: Pandi Perumal, Seithikurippu R.. King Saud University; Arabia SauditaFil: BaHammam, Ahmed S.. King Saud University; Arabia SauditaFil: Ojike, Nwakile I.. King Saud University; Arabia SauditaFil: Akinseye, Oluwaseun A.. University of New York; Estados UnidosFil: Kendzerska, Tetyana. Sunnybrook Health Sciences Center; CanadáFil: Buttoo, Kenneth. Sleep Disorders Center; CanadáFil: Dhandapany, Perundurai S.. Oregon Health And Science University; Estados UnidosFil: Brown, Gregory M.. University of Toronto; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina ; ArgentinaSAGE Publications2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47960Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Ojike, Nwakile I.; Akinseye, Oluwaseun A.; Kendzerska, Tetyana; et al.; Melatonin and Human Cardiovascular Disease; SAGE Publications; Journal Of Cardiovascular Pharmacology And Therapeutics; 22; 2; 7-2016; 122-1321074-2484CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/1074248416660622info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1074248416660622info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:41Zoai:ri.conicet.gov.ar:11336/47960instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:41.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Melatonin and Human Cardiovascular Disease
title Melatonin and Human Cardiovascular Disease
spellingShingle Melatonin and Human Cardiovascular Disease
Pandi Perumal, Seithikurippu R.
blood pressure
cardioprotection
cardiovascular disorders
coronary artery disease
hypertension
melatonin
platelets
title_short Melatonin and Human Cardiovascular Disease
title_full Melatonin and Human Cardiovascular Disease
title_fullStr Melatonin and Human Cardiovascular Disease
title_full_unstemmed Melatonin and Human Cardiovascular Disease
title_sort Melatonin and Human Cardiovascular Disease
dc.creator.none.fl_str_mv Pandi Perumal, Seithikurippu R.
BaHammam, Ahmed S.
Ojike, Nwakile I.
Akinseye, Oluwaseun A.
Kendzerska, Tetyana
Buttoo, Kenneth
Dhandapany, Perundurai S.
Brown, Gregory M.
Cardinali, Daniel Pedro
author Pandi Perumal, Seithikurippu R.
author_facet Pandi Perumal, Seithikurippu R.
BaHammam, Ahmed S.
Ojike, Nwakile I.
Akinseye, Oluwaseun A.
Kendzerska, Tetyana
Buttoo, Kenneth
Dhandapany, Perundurai S.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_role author
author2 BaHammam, Ahmed S.
Ojike, Nwakile I.
Akinseye, Oluwaseun A.
Kendzerska, Tetyana
Buttoo, Kenneth
Dhandapany, Perundurai S.
Brown, Gregory M.
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv blood pressure
cardioprotection
cardiovascular disorders
coronary artery disease
hypertension
melatonin
platelets
topic blood pressure
cardioprotection
cardiovascular disorders
coronary artery disease
hypertension
melatonin
platelets
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.
Fil: Pandi Perumal, Seithikurippu R.. King Saud University; Arabia Saudita
Fil: BaHammam, Ahmed S.. King Saud University; Arabia Saudita
Fil: Ojike, Nwakile I.. King Saud University; Arabia Saudita
Fil: Akinseye, Oluwaseun A.. University of New York; Estados Unidos
Fil: Kendzerska, Tetyana. Sunnybrook Health Sciences Center; Canadá
Fil: Buttoo, Kenneth. Sleep Disorders Center; Canadá
Fil: Dhandapany, Perundurai S.. Oregon Health And Science University; Estados Unidos
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina ; Argentina
description The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47960
Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Ojike, Nwakile I.; Akinseye, Oluwaseun A.; Kendzerska, Tetyana; et al.; Melatonin and Human Cardiovascular Disease; SAGE Publications; Journal Of Cardiovascular Pharmacology And Therapeutics; 22; 2; 7-2016; 122-132
1074-2484
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47960
identifier_str_mv Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Ojike, Nwakile I.; Akinseye, Oluwaseun A.; Kendzerska, Tetyana; et al.; Melatonin and Human Cardiovascular Disease; SAGE Publications; Journal Of Cardiovascular Pharmacology And Therapeutics; 22; 2; 7-2016; 122-132
1074-2484
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/1074248416660622
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1074248416660622
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614036505755648
score 13.070432

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