Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease

Autores
Talvani, Andre; Rocha, Manoel O. C.; Ribeiro, Antonio L.; Borda, Enri Santiago; Sterin Borda, Leonor; Teixeira, Mauro M.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chronic chagasic cardiomyopathy (CCC) is characterized mainly by a dilated cardiomyopathy complicated by frequent and complex ventricular arrhythmias and/or conduction defects. The aim of the present study was to evaluate functional implications of neurotransmitter receptor autoantibodies in vivo. Sera from chagasic patients were used to measure the level of autoantibodies to peptide fragments from the M2 cholinergic and β1 adrenergic receptors. Optical density values and the frequency of anti-M2 and anti-β1 antibodies were significantly higher in the indeterminate form and in CCC patients than in normal individuals. There was no correlation between levels of autoantibodies and clinical parameters of ventricular dysfunction, as assessed by echocardiography. Patients presenting with chronotropic insufficiency in exercise test had higher levels of anti-M2 but not anti-β1 autoantibodies. Although anti-M2 and anti-β1 antibodies do not appear to play a role in the pathophysiology of the heart failure that accompanies severe CCC, anti-M2 cholinergic autoantibodies may contribute to the pathogenesis of Chagas' disease dysautonomia.
Fil: Talvani, Andre. Universidade Federal de Minas Gerais; Brasil
Fil: Rocha, Manoel O. C.. Universidade Federal de Minas Gerais; Brasil
Fil: Ribeiro, Antonio L.. Universidade Federal de Minas Gerais; Brasil
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Teixeira, Mauro M.. Universidade Federal de Minas Gerais; Brasil
Materia
AUTOANTIBODY
CARDIOMYOPATHY
CHAGAS' DISEASE
NEUROTRANSMITTER RECEPTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112793
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart diseaseTalvani, AndreRocha, Manoel O. C.Ribeiro, Antonio L.Borda, Enri SantiagoSterin Borda, LeonorTeixeira, Mauro M.AUTOANTIBODYCARDIOMYOPATHYCHAGAS' DISEASENEUROTRANSMITTER RECEPTORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Chronic chagasic cardiomyopathy (CCC) is characterized mainly by a dilated cardiomyopathy complicated by frequent and complex ventricular arrhythmias and/or conduction defects. The aim of the present study was to evaluate functional implications of neurotransmitter receptor autoantibodies in vivo. Sera from chagasic patients were used to measure the level of autoantibodies to peptide fragments from the M2 cholinergic and β1 adrenergic receptors. Optical density values and the frequency of anti-M2 and anti-β1 antibodies were significantly higher in the indeterminate form and in CCC patients than in normal individuals. There was no correlation between levels of autoantibodies and clinical parameters of ventricular dysfunction, as assessed by echocardiography. Patients presenting with chronotropic insufficiency in exercise test had higher levels of anti-M2 but not anti-β1 autoantibodies. Although anti-M2 and anti-β1 antibodies do not appear to play a role in the pathophysiology of the heart failure that accompanies severe CCC, anti-M2 cholinergic autoantibodies may contribute to the pathogenesis of Chagas' disease dysautonomia.Fil: Talvani, Andre. Universidade Federal de Minas Gerais; BrasilFil: Rocha, Manoel O. C.. Universidade Federal de Minas Gerais; BrasilFil: Ribeiro, Antonio L.. Universidade Federal de Minas Gerais; BrasilFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Teixeira, Mauro M.. Universidade Federal de Minas Gerais; BrasilElsevier Science2006-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112793Talvani, Andre; Rocha, Manoel O. C.; Ribeiro, Antonio L.; Borda, Enri Santiago; Sterin Borda, Leonor; et al.; Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease; Elsevier Science; Microbes and Infection; 8; 9-10; 8-2006; 2459-24641286-4579CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.micinf.2006.06.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1286457906002371info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:39Zoai:ri.conicet.gov.ar:11336/112793instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:39.869CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
title Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
spellingShingle Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
Talvani, Andre
AUTOANTIBODY
CARDIOMYOPATHY
CHAGAS' DISEASE
NEUROTRANSMITTER RECEPTOR
title_short Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
title_full Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
title_fullStr Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
title_full_unstemmed Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
title_sort Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease
dc.creator.none.fl_str_mv Talvani, Andre
Rocha, Manoel O. C.
Ribeiro, Antonio L.
Borda, Enri Santiago
Sterin Borda, Leonor
Teixeira, Mauro M.
author Talvani, Andre
author_facet Talvani, Andre
Rocha, Manoel O. C.
Ribeiro, Antonio L.
Borda, Enri Santiago
Sterin Borda, Leonor
Teixeira, Mauro M.
author_role author
author2 Rocha, Manoel O. C.
Ribeiro, Antonio L.
Borda, Enri Santiago
Sterin Borda, Leonor
Teixeira, Mauro M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AUTOANTIBODY
CARDIOMYOPATHY
CHAGAS' DISEASE
NEUROTRANSMITTER RECEPTOR
topic AUTOANTIBODY
CARDIOMYOPATHY
CHAGAS' DISEASE
NEUROTRANSMITTER RECEPTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chronic chagasic cardiomyopathy (CCC) is characterized mainly by a dilated cardiomyopathy complicated by frequent and complex ventricular arrhythmias and/or conduction defects. The aim of the present study was to evaluate functional implications of neurotransmitter receptor autoantibodies in vivo. Sera from chagasic patients were used to measure the level of autoantibodies to peptide fragments from the M2 cholinergic and β1 adrenergic receptors. Optical density values and the frequency of anti-M2 and anti-β1 antibodies were significantly higher in the indeterminate form and in CCC patients than in normal individuals. There was no correlation between levels of autoantibodies and clinical parameters of ventricular dysfunction, as assessed by echocardiography. Patients presenting with chronotropic insufficiency in exercise test had higher levels of anti-M2 but not anti-β1 autoantibodies. Although anti-M2 and anti-β1 antibodies do not appear to play a role in the pathophysiology of the heart failure that accompanies severe CCC, anti-M2 cholinergic autoantibodies may contribute to the pathogenesis of Chagas' disease dysautonomia.
Fil: Talvani, Andre. Universidade Federal de Minas Gerais; Brasil
Fil: Rocha, Manoel O. C.. Universidade Federal de Minas Gerais; Brasil
Fil: Ribeiro, Antonio L.. Universidade Federal de Minas Gerais; Brasil
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Teixeira, Mauro M.. Universidade Federal de Minas Gerais; Brasil
description Chronic chagasic cardiomyopathy (CCC) is characterized mainly by a dilated cardiomyopathy complicated by frequent and complex ventricular arrhythmias and/or conduction defects. The aim of the present study was to evaluate functional implications of neurotransmitter receptor autoantibodies in vivo. Sera from chagasic patients were used to measure the level of autoantibodies to peptide fragments from the M2 cholinergic and β1 adrenergic receptors. Optical density values and the frequency of anti-M2 and anti-β1 antibodies were significantly higher in the indeterminate form and in CCC patients than in normal individuals. There was no correlation between levels of autoantibodies and clinical parameters of ventricular dysfunction, as assessed by echocardiography. Patients presenting with chronotropic insufficiency in exercise test had higher levels of anti-M2 but not anti-β1 autoantibodies. Although anti-M2 and anti-β1 antibodies do not appear to play a role in the pathophysiology of the heart failure that accompanies severe CCC, anti-M2 cholinergic autoantibodies may contribute to the pathogenesis of Chagas' disease dysautonomia.
publishDate 2006
dc.date.none.fl_str_mv 2006-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112793
Talvani, Andre; Rocha, Manoel O. C.; Ribeiro, Antonio L.; Borda, Enri Santiago; Sterin Borda, Leonor; et al.; Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease; Elsevier Science; Microbes and Infection; 8; 9-10; 8-2006; 2459-2464
1286-4579
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112793
identifier_str_mv Talvani, Andre; Rocha, Manoel O. C.; Ribeiro, Antonio L.; Borda, Enri Santiago; Sterin Borda, Leonor; et al.; Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease; Elsevier Science; Microbes and Infection; 8; 9-10; 8-2006; 2459-2464
1286-4579
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.micinf.2006.06.006
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1286457906002371
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269812713062400
score 13.13397

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