The role of Absorbing Markov Chains in childhood cancer

Autores
Margarit, David Hipólito; Reale, Marcela Verónica; Scagliotti, Ariel Fabricio; Romanelli, Lilia Mabel
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Absorbing Markov Chains are an important mathematical tool used for different applications in science. On the other hand, cancer and its metastases in children have a significant impact on health due to their degree of lethality. Therefore, the aim of this work is to model the metastatic pathways of the main childhood cancers worldwide. The probabilities of generating metastases, from a primary site to secondary and tertiary sites, were characterized by constructing a directed graph and the associated transition matrix. In addition, the time of absorption and the probabilities of absorption by each absorbing state were calculated.
Fil: Margarit, David Hipólito. Universidad Nacional de General Sarmiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Reale, Marcela Verónica. Universidad Nacional de General Sarmiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Matanza; Argentina
Fil: Scagliotti, Ariel Fabricio. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romanelli, Lilia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento; Argentina
Materia
ABSORBING MARKOV CHAINS
METASTASIS
MATHEMATICAL BIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/222474
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of Absorbing Markov Chains in childhood cancerMargarit, David HipólitoReale, Marcela VerónicaScagliotti, Ariel FabricioRomanelli, Lilia MabelABSORBING MARKOV CHAINSMETASTASISMATHEMATICAL BIOLOGYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Absorbing Markov Chains are an important mathematical tool used for different applications in science. On the other hand, cancer and its metastases in children have a significant impact on health due to their degree of lethality. Therefore, the aim of this work is to model the metastatic pathways of the main childhood cancers worldwide. The probabilities of generating metastases, from a primary site to secondary and tertiary sites, were characterized by constructing a directed graph and the associated transition matrix. In addition, the time of absorption and the probabilities of absorption by each absorbing state were calculated.Fil: Margarit, David Hipólito. Universidad Nacional de General Sarmiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reale, Marcela Verónica. Universidad Nacional de General Sarmiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Matanza; ArgentinaFil: Scagliotti, Ariel Fabricio. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romanelli, Lilia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento; ArgentinaCold Spring Harbor Laboratory Press2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/222474Margarit, David Hipólito; Reale, Marcela Verónica; Scagliotti, Ariel Fabricio; Romanelli, Lilia Mabel; The role of Absorbing Markov Chains in childhood cancer; Cold Spring Harbor Laboratory Press; Biorxiv; 4-2023; 1-152641-9165CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1101/2022.12.12.520113info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2022.12.12.520113v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:12Zoai:ri.conicet.gov.ar:11336/222474instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:12.212CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of Absorbing Markov Chains in childhood cancer
title The role of Absorbing Markov Chains in childhood cancer
spellingShingle The role of Absorbing Markov Chains in childhood cancer
Margarit, David Hipólito
ABSORBING MARKOV CHAINS
METASTASIS
MATHEMATICAL BIOLOGY
title_short The role of Absorbing Markov Chains in childhood cancer
title_full The role of Absorbing Markov Chains in childhood cancer
title_fullStr The role of Absorbing Markov Chains in childhood cancer
title_full_unstemmed The role of Absorbing Markov Chains in childhood cancer
title_sort The role of Absorbing Markov Chains in childhood cancer
dc.creator.none.fl_str_mv Margarit, David Hipólito
Reale, Marcela Verónica
Scagliotti, Ariel Fabricio
Romanelli, Lilia Mabel
author Margarit, David Hipólito
author_facet Margarit, David Hipólito
Reale, Marcela Verónica
Scagliotti, Ariel Fabricio
Romanelli, Lilia Mabel
author_role author
author2 Reale, Marcela Verónica
Scagliotti, Ariel Fabricio
Romanelli, Lilia Mabel
author2_role author
author
author
dc.subject.none.fl_str_mv ABSORBING MARKOV CHAINS
METASTASIS
MATHEMATICAL BIOLOGY
topic ABSORBING MARKOV CHAINS
METASTASIS
MATHEMATICAL BIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Absorbing Markov Chains are an important mathematical tool used for different applications in science. On the other hand, cancer and its metastases in children have a significant impact on health due to their degree of lethality. Therefore, the aim of this work is to model the metastatic pathways of the main childhood cancers worldwide. The probabilities of generating metastases, from a primary site to secondary and tertiary sites, were characterized by constructing a directed graph and the associated transition matrix. In addition, the time of absorption and the probabilities of absorption by each absorbing state were calculated.
Fil: Margarit, David Hipólito. Universidad Nacional de General Sarmiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Reale, Marcela Verónica. Universidad Nacional de General Sarmiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Matanza; Argentina
Fil: Scagliotti, Ariel Fabricio. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romanelli, Lilia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento; Argentina
description Absorbing Markov Chains are an important mathematical tool used for different applications in science. On the other hand, cancer and its metastases in children have a significant impact on health due to their degree of lethality. Therefore, the aim of this work is to model the metastatic pathways of the main childhood cancers worldwide. The probabilities of generating metastases, from a primary site to secondary and tertiary sites, were characterized by constructing a directed graph and the associated transition matrix. In addition, the time of absorption and the probabilities of absorption by each absorbing state were calculated.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/222474
Margarit, David Hipólito; Reale, Marcela Verónica; Scagliotti, Ariel Fabricio; Romanelli, Lilia Mabel; The role of Absorbing Markov Chains in childhood cancer; Cold Spring Harbor Laboratory Press; Biorxiv; 4-2023; 1-15
2641-9165
CONICET Digital
CONICET
url http://hdl.handle.net/11336/222474
identifier_str_mv Margarit, David Hipólito; Reale, Marcela Verónica; Scagliotti, Ariel Fabricio; Romanelli, Lilia Mabel; The role of Absorbing Markov Chains in childhood cancer; Cold Spring Harbor Laboratory Press; Biorxiv; 4-2023; 1-15
2641-9165
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1101/2022.12.12.520113
info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2022.12.12.520113v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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