Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
- Autores
- Fascio, Mirta Liliana; Errea, María Inés; D'accorso, Norma Beatriz
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities. Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs.
Fil: Fascio, Mirta Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Errea, María Inés. Instituto Tecnológico de Buenos Aires. Departamento de Ingeniería Química; Argentina
Fil: D'accorso, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina - Materia
-
Imidazo[2,1-B]Thiazoles
Imidazo[2,1-B]Thiadiazoles
Imidazo[2,1-C][1,2,4]Triazoles
Pyrrolo[2,1-B]Thiazoles
Biological Activities - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/17776
Ver los metadatos del registro completo
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Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological propertiesFascio, Mirta LilianaErrea, María InésD'accorso, Norma BeatrizImidazo[2,1-B]ThiazolesImidazo[2,1-B]ThiadiazolesImidazo[2,1-C][1,2,4]TriazolesPyrrolo[2,1-B]ThiazolesBiological Activitieshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities. Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs.Fil: Fascio, Mirta Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Errea, María Inés. Instituto Tecnológico de Buenos Aires. Departamento de Ingeniería Química; ArgentinaFil: D'accorso, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaElsevier Masson2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17776Fascio, Mirta Liliana; Errea, María Inés; D'accorso, Norma Beatriz; Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties; Elsevier Masson; European Journal Of Medical Chemistry; 90; 1-2015; 666-6830223-5234enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2014.12.012info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0223523414011210info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:36Zoai:ri.conicet.gov.ar:11336/17776instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:36.523CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
title |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
spellingShingle |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties Fascio, Mirta Liliana Imidazo[2,1-B]Thiazoles Imidazo[2,1-B]Thiadiazoles Imidazo[2,1-C][1,2,4]Triazoles Pyrrolo[2,1-B]Thiazoles Biological Activities |
title_short |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
title_full |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
title_fullStr |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
title_full_unstemmed |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
title_sort |
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties |
dc.creator.none.fl_str_mv |
Fascio, Mirta Liliana Errea, María Inés D'accorso, Norma Beatriz |
author |
Fascio, Mirta Liliana |
author_facet |
Fascio, Mirta Liliana Errea, María Inés D'accorso, Norma Beatriz |
author_role |
author |
author2 |
Errea, María Inés D'accorso, Norma Beatriz |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Imidazo[2,1-B]Thiazoles Imidazo[2,1-B]Thiadiazoles Imidazo[2,1-C][1,2,4]Triazoles Pyrrolo[2,1-B]Thiazoles Biological Activities |
topic |
Imidazo[2,1-B]Thiazoles Imidazo[2,1-B]Thiadiazoles Imidazo[2,1-C][1,2,4]Triazoles Pyrrolo[2,1-B]Thiazoles Biological Activities |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities. Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs. Fil: Fascio, Mirta Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina Fil: Errea, María Inés. Instituto Tecnológico de Buenos Aires. Departamento de Ingeniería Química; Argentina Fil: D'accorso, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina |
description |
Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities. Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/17776 Fascio, Mirta Liliana; Errea, María Inés; D'accorso, Norma Beatriz; Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties; Elsevier Masson; European Journal Of Medical Chemistry; 90; 1-2015; 666-683 0223-5234 |
url |
http://hdl.handle.net/11336/17776 |
identifier_str_mv |
Fascio, Mirta Liliana; Errea, María Inés; D'accorso, Norma Beatriz; Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties; Elsevier Masson; European Journal Of Medical Chemistry; 90; 1-2015; 666-683 0223-5234 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2014.12.012 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0223523414011210 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Masson |
publisher.none.fl_str_mv |
Elsevier Masson |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |