Factors associated with healthy aging in Latin American populations

Autores
Santamaria Garcia, Hernando; Sainz Ballesteros, Agustín; Hernandez, Hernán; Moguilner, Sebastian Gabriel; Maito, Marcelo; OchoaRosales, Carolina; Corley, Michael; Valcour, Victor; Miranda, J. Jaime; Lawlor, Brian; Ibañez, Agustin Mariano
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models of healthy aging. The potential combination of risk factors that influence aging across populations in Latin American and Caribbean (LAC) countries is unknown. Compared to other regions where classical factors such as age and sex drive healthy aging, higher disparity-related factors and between-country variability could influence healthy aging in LAC countries. We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n = 44,394 participants). Risk factors associated with social and health disparities, including SDH (β > 0.3), mental health (β > 0.6) and cardiometabolic risks (β > 0.22), significantly influenced healthy aging more than age and sex (with null or smaller effects: β < 0.2). These heterogeneous patterns were more pronounced in low-income to middle-income LAC countries compared to high-income LAC countries (cross-sectional comparisons), and in an upper-income to middle-income LAC country, Costa Rica, compared to China, a non-upper-income to middle-income LAC country (longitudinal comparisons). These inequity-associated and region-specific patterns inform national risk assessments of healthy aging in LAC countries and regionally tailored public health interventions.
Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia
Fil: Sainz Ballesteros, Agustín. Universidad Adolfo Ibañez; Chile
Fil: Hernandez, Hernán. Universidad Adolfo Ibañez; Chile. Universidad de Concepción; Chile
Fil: Moguilner, Sebastian Gabriel. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos
Fil: Maito, Marcelo. Universidad Adolfo Ibañez; Chile
Fil: OchoaRosales, Carolina. Universidad Adolfo Ibañez; Chile
Fil: Corley, Michael. No especifíca;
Fil: Valcour, Victor. University of California; Estados Unidos
Fil: Miranda, J. Jaime. No especifíca;
Fil: Lawlor, Brian. University of California; Estados Unidos
Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile
Materia
population diversity
healthy aging
Age
Sex
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220411
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/220411
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Factors associated with healthy aging in Latin American populationsSantamaria Garcia, HernandoSainz Ballesteros, AgustínHernandez, HernánMoguilner, Sebastian GabrielMaito, MarceloOchoaRosales, CarolinaCorley, MichaelValcour, VictorMiranda, J. JaimeLawlor, BrianIbañez, Agustin Marianopopulation diversityhealthy agingAgeSexhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models of healthy aging. The potential combination of risk factors that influence aging across populations in Latin American and Caribbean (LAC) countries is unknown. Compared to other regions where classical factors such as age and sex drive healthy aging, higher disparity-related factors and between-country variability could influence healthy aging in LAC countries. We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n = 44,394 participants). Risk factors associated with social and health disparities, including SDH (β > 0.3), mental health (β > 0.6) and cardiometabolic risks (β > 0.22), significantly influenced healthy aging more than age and sex (with null or smaller effects: β < 0.2). These heterogeneous patterns were more pronounced in low-income to middle-income LAC countries compared to high-income LAC countries (cross-sectional comparisons), and in an upper-income to middle-income LAC country, Costa Rica, compared to China, a non-upper-income to middle-income LAC country (longitudinal comparisons). These inequity-associated and region-specific patterns inform national risk assessments of healthy aging in LAC countries and regionally tailored public health interventions.Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; ColombiaFil: Sainz Ballesteros, Agustín. Universidad Adolfo Ibañez; ChileFil: Hernandez, Hernán. Universidad Adolfo Ibañez; Chile. Universidad de Concepción; ChileFil: Moguilner, Sebastian Gabriel. Universidad Adolfo Ibañez; Chile. University of California; Estados UnidosFil: Maito, Marcelo. Universidad Adolfo Ibañez; ChileFil: OchoaRosales, Carolina. Universidad Adolfo Ibañez; ChileFil: Corley, Michael. No especifíca;Fil: Valcour, Victor. University of California; Estados UnidosFil: Miranda, J. Jaime. No especifíca;Fil: Lawlor, Brian. University of California; Estados UnidosFil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; ChileNature Publishing Group2023-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220411Santamaria Garcia, Hernando; Sainz Ballesteros, Agustín; Hernandez, Hernán; Moguilner, Sebastian Gabriel; Maito, Marcelo; et al.; Factors associated with healthy aging in Latin American populations; Nature Publishing Group; Nature Medicine; 29; 9; 9-2023; 2248-22581078-8956CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41591-023-02495-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:17:11Zoai:ri.conicet.gov.ar:11336/220411instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:17:11.853CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Factors associated with healthy aging in Latin American populations
title Factors associated with healthy aging in Latin American populations
spellingShingle Factors associated with healthy aging in Latin American populations
Santamaria Garcia, Hernando
population diversity
healthy aging
Age
Sex
title_short Factors associated with healthy aging in Latin American populations
title_full Factors associated with healthy aging in Latin American populations
title_fullStr Factors associated with healthy aging in Latin American populations
title_full_unstemmed Factors associated with healthy aging in Latin American populations
title_sort Factors associated with healthy aging in Latin American populations
dc.creator.none.fl_str_mv Santamaria Garcia, Hernando
Sainz Ballesteros, Agustín
Hernandez, Hernán
Moguilner, Sebastian Gabriel
Maito, Marcelo
OchoaRosales, Carolina
Corley, Michael
Valcour, Victor
Miranda, J. Jaime
Lawlor, Brian
Ibañez, Agustin Mariano
author Santamaria Garcia, Hernando
author_facet Santamaria Garcia, Hernando
Sainz Ballesteros, Agustín
Hernandez, Hernán
Moguilner, Sebastian Gabriel
Maito, Marcelo
OchoaRosales, Carolina
Corley, Michael
Valcour, Victor
Miranda, J. Jaime
Lawlor, Brian
Ibañez, Agustin Mariano
author_role author
author2 Sainz Ballesteros, Agustín
Hernandez, Hernán
Moguilner, Sebastian Gabriel
Maito, Marcelo
OchoaRosales, Carolina
Corley, Michael
Valcour, Victor
Miranda, J. Jaime
Lawlor, Brian
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv population diversity
healthy aging
Age
Sex
topic population diversity
healthy aging
Age
Sex
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models of healthy aging. The potential combination of risk factors that influence aging across populations in Latin American and Caribbean (LAC) countries is unknown. Compared to other regions where classical factors such as age and sex drive healthy aging, higher disparity-related factors and between-country variability could influence healthy aging in LAC countries. We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n = 44,394 participants). Risk factors associated with social and health disparities, including SDH (β > 0.3), mental health (β > 0.6) and cardiometabolic risks (β > 0.22), significantly influenced healthy aging more than age and sex (with null or smaller effects: β < 0.2). These heterogeneous patterns were more pronounced in low-income to middle-income LAC countries compared to high-income LAC countries (cross-sectional comparisons), and in an upper-income to middle-income LAC country, Costa Rica, compared to China, a non-upper-income to middle-income LAC country (longitudinal comparisons). These inequity-associated and region-specific patterns inform national risk assessments of healthy aging in LAC countries and regionally tailored public health interventions.
Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia
Fil: Sainz Ballesteros, Agustín. Universidad Adolfo Ibañez; Chile
Fil: Hernandez, Hernán. Universidad Adolfo Ibañez; Chile. Universidad de Concepción; Chile
Fil: Moguilner, Sebastian Gabriel. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos
Fil: Maito, Marcelo. Universidad Adolfo Ibañez; Chile
Fil: OchoaRosales, Carolina. Universidad Adolfo Ibañez; Chile
Fil: Corley, Michael. No especifíca;
Fil: Valcour, Victor. University of California; Estados Unidos
Fil: Miranda, J. Jaime. No especifíca;
Fil: Lawlor, Brian. University of California; Estados Unidos
Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile
description Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models of healthy aging. The potential combination of risk factors that influence aging across populations in Latin American and Caribbean (LAC) countries is unknown. Compared to other regions where classical factors such as age and sex drive healthy aging, higher disparity-related factors and between-country variability could influence healthy aging in LAC countries. We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n = 44,394 participants). Risk factors associated with social and health disparities, including SDH (β > 0.3), mental health (β > 0.6) and cardiometabolic risks (β > 0.22), significantly influenced healthy aging more than age and sex (with null or smaller effects: β < 0.2). These heterogeneous patterns were more pronounced in low-income to middle-income LAC countries compared to high-income LAC countries (cross-sectional comparisons), and in an upper-income to middle-income LAC country, Costa Rica, compared to China, a non-upper-income to middle-income LAC country (longitudinal comparisons). These inequity-associated and region-specific patterns inform national risk assessments of healthy aging in LAC countries and regionally tailored public health interventions.
publishDate 2023
dc.date.none.fl_str_mv 2023-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220411
Santamaria Garcia, Hernando; Sainz Ballesteros, Agustín; Hernandez, Hernán; Moguilner, Sebastian Gabriel; Maito, Marcelo; et al.; Factors associated with healthy aging in Latin American populations; Nature Publishing Group; Nature Medicine; 29; 9; 9-2023; 2248-2258
1078-8956
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220411
identifier_str_mv Santamaria Garcia, Hernando; Sainz Ballesteros, Agustín; Hernandez, Hernán; Moguilner, Sebastian Gabriel; Maito, Marcelo; et al.; Factors associated with healthy aging in Latin American populations; Nature Publishing Group; Nature Medicine; 29; 9; 9-2023; 2248-2258
1078-8956
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41591-023-02495-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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