Mechanical properties of binary DPPC/DPPS bilayers
- Autores
- Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes.
Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
Fil: Oliveira Costa, Sara Dinisa. Universidad Politécnica de Cartagena; España
Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Politécnica de Cartagena; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Politécnica de Cartagena; España - Materia
-
Molecular Dynamics
DPPC/DPPS bilayers
Molecular properties - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/141180
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Mechanical properties of binary DPPC/DPPS bilayersLopez Cascales, Jose JavierOliveira Costa, Sara DinisaGarro, AdrianaEnriz, Ricardo DanielMolecular DynamicsDPPC/DPPS bilayersMolecular propertieshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes.Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; EspañaFil: Oliveira Costa, Sara Dinisa. Universidad Politécnica de Cartagena; EspañaFil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Politécnica de Cartagena; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Politécnica de Cartagena; EspañaRoyal Society of Chemistry2012-12-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141180Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel; Mechanical properties of binary DPPC/DPPS bilayers; Royal Society of Chemistry; RSC Advances; 2; 31; 7-12-2012; 11743-117502046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2012/RA/c2ra21977hinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C2RA21977Hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:24Zoai:ri.conicet.gov.ar:11336/141180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:24.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Mechanical properties of binary DPPC/DPPS bilayers |
title |
Mechanical properties of binary DPPC/DPPS bilayers |
spellingShingle |
Mechanical properties of binary DPPC/DPPS bilayers Lopez Cascales, Jose Javier Molecular Dynamics DPPC/DPPS bilayers Molecular properties |
title_short |
Mechanical properties of binary DPPC/DPPS bilayers |
title_full |
Mechanical properties of binary DPPC/DPPS bilayers |
title_fullStr |
Mechanical properties of binary DPPC/DPPS bilayers |
title_full_unstemmed |
Mechanical properties of binary DPPC/DPPS bilayers |
title_sort |
Mechanical properties of binary DPPC/DPPS bilayers |
dc.creator.none.fl_str_mv |
Lopez Cascales, Jose Javier Oliveira Costa, Sara Dinisa Garro, Adriana Enriz, Ricardo Daniel |
author |
Lopez Cascales, Jose Javier |
author_facet |
Lopez Cascales, Jose Javier Oliveira Costa, Sara Dinisa Garro, Adriana Enriz, Ricardo Daniel |
author_role |
author |
author2 |
Oliveira Costa, Sara Dinisa Garro, Adriana Enriz, Ricardo Daniel |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Molecular Dynamics DPPC/DPPS bilayers Molecular properties |
topic |
Molecular Dynamics DPPC/DPPS bilayers Molecular properties |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes. Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España Fil: Oliveira Costa, Sara Dinisa. Universidad Politécnica de Cartagena; España Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Politécnica de Cartagena; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Politécnica de Cartagena; España |
description |
In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/141180 Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel; Mechanical properties of binary DPPC/DPPS bilayers; Royal Society of Chemistry; RSC Advances; 2; 31; 7-12-2012; 11743-11750 2046-2069 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/141180 |
identifier_str_mv |
Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel; Mechanical properties of binary DPPC/DPPS bilayers; Royal Society of Chemistry; RSC Advances; 2; 31; 7-12-2012; 11743-11750 2046-2069 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2012/RA/c2ra21977h info:eu-repo/semantics/altIdentifier/doi/10.1039/C2RA21977H |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |