Mechanical properties of binary DPPC/DPPS bilayers

Autores
Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes.
Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
Fil: Oliveira Costa, Sara Dinisa. Universidad Politécnica de Cartagena; España
Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Politécnica de Cartagena; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Politécnica de Cartagena; España
Materia
Molecular Dynamics
DPPC/DPPS bilayers
Molecular properties
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141180
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanical properties of binary DPPC/DPPS bilayersLopez Cascales, Jose JavierOliveira Costa, Sara DinisaGarro, AdrianaEnriz, Ricardo DanielMolecular DynamicsDPPC/DPPS bilayersMolecular propertieshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes.Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; EspañaFil: Oliveira Costa, Sara Dinisa. Universidad Politécnica de Cartagena; EspañaFil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Politécnica de Cartagena; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Politécnica de Cartagena; EspañaRoyal Society of Chemistry2012-12-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141180Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel; Mechanical properties of binary DPPC/DPPS bilayers; Royal Society of Chemistry; RSC Advances; 2; 31; 7-12-2012; 11743-117502046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2012/RA/c2ra21977hinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C2RA21977Hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:17:23Zoai:ri.conicet.gov.ar:11336/141180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:17:23.326CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanical properties of binary DPPC/DPPS bilayers
title Mechanical properties of binary DPPC/DPPS bilayers
spellingShingle Mechanical properties of binary DPPC/DPPS bilayers
Lopez Cascales, Jose Javier
Molecular Dynamics
DPPC/DPPS bilayers
Molecular properties
title_short Mechanical properties of binary DPPC/DPPS bilayers
title_full Mechanical properties of binary DPPC/DPPS bilayers
title_fullStr Mechanical properties of binary DPPC/DPPS bilayers
title_full_unstemmed Mechanical properties of binary DPPC/DPPS bilayers
title_sort Mechanical properties of binary DPPC/DPPS bilayers
dc.creator.none.fl_str_mv Lopez Cascales, Jose Javier
Oliveira Costa, Sara Dinisa
Garro, Adriana
Enriz, Ricardo Daniel
author Lopez Cascales, Jose Javier
author_facet Lopez Cascales, Jose Javier
Oliveira Costa, Sara Dinisa
Garro, Adriana
Enriz, Ricardo Daniel
author_role author
author2 Oliveira Costa, Sara Dinisa
Garro, Adriana
Enriz, Ricardo Daniel
author2_role author
author
author
dc.subject.none.fl_str_mv Molecular Dynamics
DPPC/DPPS bilayers
Molecular properties
topic Molecular Dynamics
DPPC/DPPS bilayers
Molecular properties
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes.
Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
Fil: Oliveira Costa, Sara Dinisa. Universidad Politécnica de Cartagena; España
Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Politécnica de Cartagena; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Politécnica de Cartagena; España
description In this work, we studied how the lipid composition and ionic strength of an aqueous solution affect the mechanical properties of the lipid bilayer. The interfacial tension, the bending modulus, the Gaussian curvature modulus and the bilayer curvature energy of the lipid bilayer were studied by molecular dynamics simulation. For this purpose, the lipid bilayer was modelled as a binary symmetric lipid bilayer of DPPC (DiPalmitoylPhosphatidylCholine) and DPPS (DiPalmitoylPhosphatidylSerine) at different molar ratios of these two lipids in the absence of salt and in presence of 0.5 N NaCl in aqueous solution. The results of the simulations in absence of salt showed how an increase in the DPPS concentration of the lipid bilayer strongly affects most of its mechanical properties, including the lateral pressure across the membrane, interfacial tension, or the bending modulus of the lipid bilayer. However, in the presence of 0.5 N NaCl, the interfacial tension of the lipid bilayer becomes independent of the lipid composition (in the range of 15-70% DPPS), behavior that may have notable implications from a biological point of view, due to the contribution that this property may provide to the stability of biological membranes.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141180
Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel; Mechanical properties of binary DPPC/DPPS bilayers; Royal Society of Chemistry; RSC Advances; 2; 31; 7-12-2012; 11743-11750
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141180
identifier_str_mv Lopez Cascales, Jose Javier; Oliveira Costa, Sara Dinisa; Garro, Adriana; Enriz, Ricardo Daniel; Mechanical properties of binary DPPC/DPPS bilayers; Royal Society of Chemistry; RSC Advances; 2; 31; 7-12-2012; 11743-11750
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2012/RA/c2ra21977h
info:eu-repo/semantics/altIdentifier/doi/10.1039/C2RA21977H
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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