D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism

Autores
Ballion, Bérangère; Frenois, Francois; Zold, Camila Lidia; Chetrit, Jonathan; Murer, Mario Gustavo; Gonon, Francois
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In Parkinson´s disease dopamine depletion imbalances the two major output pathways of the striatum. L-DOPA replacement therapy is believed to correct this imbalance by providing effective D1 and D2 receptor stimulation to striatonigral and striatopallidal neurons, respectively. Here we tested this assumption in the rat model of Parkinsonism by monitoring the spike response of identified striatal neurons to cortical stimulation. As predicted, in 6-hydroxydopamine lesioned rats we observed that L-DOPA (6 mg/kg+benserazide), apomorphine and the D2 agonist quinpirole (0.5 mg/kg i.p.) counteract the enhanced responsiveness of striatopallidal neurons. Unexpectedly, the depressed responsiveness of striatonigral neurons was corrected by quinpirole whereas D1 stimulation exerted no (apomorphine, cPB) or worsening effects (L-DOPA, SKF38393 10 mg/kg). Therefore, quinpirole, but not D1 stimulation, restores functional equilibrium between the two striatal output pathways. Our results might explain the therapeutic effect of D2-based medications in Parkinson´s disease.
Fil: Ballion, Bérangère. Universite de Bordeaux; Francia
Fil: Frenois, Francois. Universite de Bordeaux; Francia
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Chetrit, Jonathan. Universite de Bordeaux; Francia
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Gonon, Francois. Universite de Bordeaux; Francia
Materia
Parkinson's disease
Electrophysiology
Striatum
Levodopa
Quinpirole
Dopamine
Striatonigral
Striatopallidal
GABA interneuron
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162292
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/162292
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of ParkinsonismBallion, BérangèreFrenois, FrancoisZold, Camila LidiaChetrit, JonathanMurer, Mario GustavoGonon, FrancoisParkinson's diseaseElectrophysiologyStriatumLevodopaQuinpiroleDopamineStriatonigralStriatopallidalGABA interneuronhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In Parkinson´s disease dopamine depletion imbalances the two major output pathways of the striatum. L-DOPA replacement therapy is believed to correct this imbalance by providing effective D1 and D2 receptor stimulation to striatonigral and striatopallidal neurons, respectively. Here we tested this assumption in the rat model of Parkinsonism by monitoring the spike response of identified striatal neurons to cortical stimulation. As predicted, in 6-hydroxydopamine lesioned rats we observed that L-DOPA (6 mg/kg+benserazide), apomorphine and the D2 agonist quinpirole (0.5 mg/kg i.p.) counteract the enhanced responsiveness of striatopallidal neurons. Unexpectedly, the depressed responsiveness of striatonigral neurons was corrected by quinpirole whereas D1 stimulation exerted no (apomorphine, cPB) or worsening effects (L-DOPA, SKF38393 10 mg/kg). Therefore, quinpirole, but not D1 stimulation, restores functional equilibrium between the two striatal output pathways. Our results might explain the therapeutic effect of D2-based medications in Parkinson´s disease.Fil: Ballion, Bérangère. Universite de Bordeaux; FranciaFil: Frenois, Francois. Universite de Bordeaux; FranciaFil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Chetrit, Jonathan. Universite de Bordeaux; FranciaFil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Gonon, Francois. Universite de Bordeaux; FranciaAcademic Press Inc Elsevier Science2009-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162292Ballion, Bérangère; Frenois, Francois; Zold, Camila Lidia; Chetrit, Jonathan; Murer, Mario Gustavo; et al.; D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism; Academic Press Inc Elsevier Science; Neurobiology of Disease; 35; 3; 9-2009; 376-3840969-9961CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969996109001302info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2009.05.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:01:24Zoai:ri.conicet.gov.ar:11336/162292instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:01:25.062CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
title D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
spellingShingle D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
Ballion, Bérangère
Parkinson's disease
Electrophysiology
Striatum
Levodopa
Quinpirole
Dopamine
Striatonigral
Striatopallidal
GABA interneuron
title_short D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
title_full D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
title_fullStr D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
title_full_unstemmed D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
title_sort D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
dc.creator.none.fl_str_mv Ballion, Bérangère
Frenois, Francois
Zold, Camila Lidia
Chetrit, Jonathan
Murer, Mario Gustavo
Gonon, Francois
author Ballion, Bérangère
author_facet Ballion, Bérangère
Frenois, Francois
Zold, Camila Lidia
Chetrit, Jonathan
Murer, Mario Gustavo
Gonon, Francois
author_role author
author2 Frenois, Francois
Zold, Camila Lidia
Chetrit, Jonathan
Murer, Mario Gustavo
Gonon, Francois
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Parkinson's disease
Electrophysiology
Striatum
Levodopa
Quinpirole
Dopamine
Striatonigral
Striatopallidal
GABA interneuron
topic Parkinson's disease
Electrophysiology
Striatum
Levodopa
Quinpirole
Dopamine
Striatonigral
Striatopallidal
GABA interneuron
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In Parkinson´s disease dopamine depletion imbalances the two major output pathways of the striatum. L-DOPA replacement therapy is believed to correct this imbalance by providing effective D1 and D2 receptor stimulation to striatonigral and striatopallidal neurons, respectively. Here we tested this assumption in the rat model of Parkinsonism by monitoring the spike response of identified striatal neurons to cortical stimulation. As predicted, in 6-hydroxydopamine lesioned rats we observed that L-DOPA (6 mg/kg+benserazide), apomorphine and the D2 agonist quinpirole (0.5 mg/kg i.p.) counteract the enhanced responsiveness of striatopallidal neurons. Unexpectedly, the depressed responsiveness of striatonigral neurons was corrected by quinpirole whereas D1 stimulation exerted no (apomorphine, cPB) or worsening effects (L-DOPA, SKF38393 10 mg/kg). Therefore, quinpirole, but not D1 stimulation, restores functional equilibrium between the two striatal output pathways. Our results might explain the therapeutic effect of D2-based medications in Parkinson´s disease.
Fil: Ballion, Bérangère. Universite de Bordeaux; Francia
Fil: Frenois, Francois. Universite de Bordeaux; Francia
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Chetrit, Jonathan. Universite de Bordeaux; Francia
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Gonon, Francois. Universite de Bordeaux; Francia
description In Parkinson´s disease dopamine depletion imbalances the two major output pathways of the striatum. L-DOPA replacement therapy is believed to correct this imbalance by providing effective D1 and D2 receptor stimulation to striatonigral and striatopallidal neurons, respectively. Here we tested this assumption in the rat model of Parkinsonism by monitoring the spike response of identified striatal neurons to cortical stimulation. As predicted, in 6-hydroxydopamine lesioned rats we observed that L-DOPA (6 mg/kg+benserazide), apomorphine and the D2 agonist quinpirole (0.5 mg/kg i.p.) counteract the enhanced responsiveness of striatopallidal neurons. Unexpectedly, the depressed responsiveness of striatonigral neurons was corrected by quinpirole whereas D1 stimulation exerted no (apomorphine, cPB) or worsening effects (L-DOPA, SKF38393 10 mg/kg). Therefore, quinpirole, but not D1 stimulation, restores functional equilibrium between the two striatal output pathways. Our results might explain the therapeutic effect of D2-based medications in Parkinson´s disease.
publishDate 2009
dc.date.none.fl_str_mv 2009-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162292
Ballion, Bérangère; Frenois, Francois; Zold, Camila Lidia; Chetrit, Jonathan; Murer, Mario Gustavo; et al.; D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism; Academic Press Inc Elsevier Science; Neurobiology of Disease; 35; 3; 9-2009; 376-384
0969-9961
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162292
identifier_str_mv Ballion, Bérangère; Frenois, Francois; Zold, Camila Lidia; Chetrit, Jonathan; Murer, Mario Gustavo; et al.; D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism; Academic Press Inc Elsevier Science; Neurobiology of Disease; 35; 3; 9-2009; 376-384
0969-9961
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969996109001302
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2009.05.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781197336707072
score 12.982451

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