Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
- Autores
- Moreno Torrejon, Laura; Bistoletti, Mariana; Lifschitz, Adrian Luis; Alvarez, Luis Ignacio; Lanusse, Carlos Edmundo
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition.
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental - Materia
-
Ivermectin
Nitroxynil
Co-Administration - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/268504
Ver los metadatos del registro completo
id |
CONICETDig_daa6eb1799deab95fda5e6fcd331c2ab |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/268504 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic dispositionMoreno Torrejon, LauraBistoletti, MarianaLifschitz, Adrian LuisAlvarez, Luis IgnacioLanusse, Carlos EdmundoIvermectinNitroxynilCo-Administrationhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition.Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaXL Reunión Anual de la Sociedad Argentina de Farmacología ExperimentalTandilArgentinaSociedad Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/268504Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:21Zoai:ri.conicet.gov.ar:11336/268504instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:21.75CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
title |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
spellingShingle |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition Moreno Torrejon, Laura Ivermectin Nitroxynil Co-Administration |
title_short |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
title_full |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
title_fullStr |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
title_full_unstemmed |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
title_sort |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition |
dc.creator.none.fl_str_mv |
Moreno Torrejon, Laura Bistoletti, Mariana Lifschitz, Adrian Luis Alvarez, Luis Ignacio Lanusse, Carlos Edmundo |
author |
Moreno Torrejon, Laura |
author_facet |
Moreno Torrejon, Laura Bistoletti, Mariana Lifschitz, Adrian Luis Alvarez, Luis Ignacio Lanusse, Carlos Edmundo |
author_role |
author |
author2 |
Bistoletti, Mariana Lifschitz, Adrian Luis Alvarez, Luis Ignacio Lanusse, Carlos Edmundo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ivermectin Nitroxynil Co-Administration |
topic |
Ivermectin Nitroxynil Co-Administration |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition. Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental Tandil Argentina Sociedad Argentina de Farmacología Experimental |
description |
Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/268504 Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/268504 |
identifier_str_mv |
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/msword application/pdf |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Farmacología Experimental |
publisher.none.fl_str_mv |
Sociedad Argentina de Farmacología Experimental |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614383884304384 |
score |
13.070432 |