Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition

Autores
Moreno Torrejon, Laura; Bistoletti, Mariana; Lifschitz, Adrian Luis; Alvarez, Luis Ignacio; Lanusse, Carlos Edmundo
Año de publicación
2008
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition.
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental
Materia
Ivermectin
Nitroxynil
Co-Administration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268504
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/268504
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic dispositionMoreno Torrejon, LauraBistoletti, MarianaLifschitz, Adrian LuisAlvarez, Luis IgnacioLanusse, Carlos EdmundoIvermectinNitroxynilCo-Administrationhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition.Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaXL Reunión Anual de la Sociedad Argentina de Farmacología ExperimentalTandilArgentinaSociedad Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/268504Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:08:40Zoai:ri.conicet.gov.ar:11336/268504instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:08:40.363CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
title Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
spellingShingle Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
Moreno Torrejon, Laura
Ivermectin
Nitroxynil
Co-Administration
title_short Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
title_full Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
title_fullStr Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
title_full_unstemmed Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
title_sort Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition
dc.creator.none.fl_str_mv Moreno Torrejon, Laura
Bistoletti, Mariana
Lifschitz, Adrian Luis
Alvarez, Luis Ignacio
Lanusse, Carlos Edmundo
author Moreno Torrejon, Laura
author_facet Moreno Torrejon, Laura
Bistoletti, Mariana
Lifschitz, Adrian Luis
Alvarez, Luis Ignacio
Lanusse, Carlos Edmundo
author_role author
author2 Bistoletti, Mariana
Lifschitz, Adrian Luis
Alvarez, Luis Ignacio
Lanusse, Carlos Edmundo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ivermectin
Nitroxynil
Co-Administration
topic Ivermectin
Nitroxynil
Co-Administration
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition.
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental
description Ivermectin (IVM) is an endectocide compound from the avermectin family. Nitroxynil (NTX) is a trematodicidal compound. Combination of different drug molecules is a modern and challenging approach in parasite control. The aim of the present work was to study the plasma disposition of both IVM and NTX after subcutaneous (SC) co-administration to sheep with different body conditions. Two groups (n= 8) of sheep with statistical different body weight (fat and thin) were treated with Nitromectin (IVM 200 μg/kg and NTX 10 mg/kg) by the SC route. Blood samples were collected up to 60 days post-treatment and plasma concentrations of IVM and NTX were determined by HPLC. IVM and NTX were well absorbed after its co-administration. Higher IVM plasma concentrations were measured in “thin” sheep compared to the “fat” group. However, NTX plasma concentrations in the thin were lower than these measured in fat group. A large volume of distribution (IVM) and high plasma protein binding (NTX) help to explain the observed pharmacokinetic differences for these drugs in animals with different body condition.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268504
Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268504
identifier_str_mv Ivermectin and nitroxynil co-Administration in sheep: effect of body condition on their kinectic disposition; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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