Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina

Autores
Amé, María Valeria; Galanti, Lucas Nicolás; Menone, Mirta Lujan; Gerpe, Marcela Silvia; Moreno, Victor Jorge; Wunderlin, Daniel Alberto
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We evaluated the presence of four common microcystins (MC–LR, –RR, –YR and –LA) in water samples and tissues (liver and muscle) of Odontesthes bonariensis collected in Los Padres Lake (Argentina). MCs were quantified by HPLC–ESI-MS/MS. The total content of MCs in water samples (2.8 ± 5.6 μg L−1) and in O. bonariensis muscle (3.9 ± 2.2 μg kg−1) never surpassed guidelines values recommended by WHO for either recreational use of water or fish consumption. The total content of MCs in O. bonariensis liver was 33.6 ± 37.2 μg kg−1. However, we observed both spatial and temporal changes in MC profile, suggesting the need of an intensive monitoring program at such lake to ensure the health of people living in its surrounding. We observed a significant correlation between the content of total and dissolved MC in water and the concentration of these toxins in liver, showing the probable uptake of dissolved MC by O. bonariensis. MC–RR was the dominant variant in water samples, followed by MC–LA and MC–LR. MC–YR was always present in water samples, but in the lowest concentrations of the congeners measured. MC content in liver in O. bonariensis was ten-fold higher than the corresponding content in fish muscle. However, MCs were present in muscle of O. bonariensis during both wet and dry season, while we could not detect MCs in liver during the dry season. These results demonstrate that MC accumulation in liver and muscle of O. bonariensis occurred with different profiles. Moreover, different uptake, tissue distribution and excretion pathways may occur between diverse MC variants. For instance, during the dry season, an increase in the relative percentage of MC–LR in water samples was accompanied with an augmentation in the relative percentage of this toxin in muscle of O. bonariensis. Conversely, a rise in the relative percentage of MC–LA in water samples during the dry season did not impact on the distribution of this toxin in fish muscle. These results suggest the need of further studies on dynamics of different variants of MC to pursuit a complete evaluation of human health risk associated to MC occurrence.
Fil: Amé, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Galanti, Lucas Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Menone, Mirta Lujan. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerpe, Marcela Silvia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moreno, Victor Jorge. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina
Fil: Wunderlin, Daniel Alberto. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
Bioaccumulation
Cyanotoxins
Fish
LCMS/MS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96292
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in ArgentinaAmé, María ValeriaGalanti, Lucas NicolásMenone, Mirta LujanGerpe, Marcela SilviaMoreno, Victor JorgeWunderlin, Daniel AlbertoBioaccumulationCyanotoxinsFishLCMS/MShttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1We evaluated the presence of four common microcystins (MC–LR, –RR, –YR and –LA) in water samples and tissues (liver and muscle) of Odontesthes bonariensis collected in Los Padres Lake (Argentina). MCs were quantified by HPLC–ESI-MS/MS. The total content of MCs in water samples (2.8 ± 5.6 μg L−1) and in O. bonariensis muscle (3.9 ± 2.2 μg kg−1) never surpassed guidelines values recommended by WHO for either recreational use of water or fish consumption. The total content of MCs in O. bonariensis liver was 33.6 ± 37.2 μg kg−1. However, we observed both spatial and temporal changes in MC profile, suggesting the need of an intensive monitoring program at such lake to ensure the health of people living in its surrounding. We observed a significant correlation between the content of total and dissolved MC in water and the concentration of these toxins in liver, showing the probable uptake of dissolved MC by O. bonariensis. MC–RR was the dominant variant in water samples, followed by MC–LA and MC–LR. MC–YR was always present in water samples, but in the lowest concentrations of the congeners measured. MC content in liver in O. bonariensis was ten-fold higher than the corresponding content in fish muscle. However, MCs were present in muscle of O. bonariensis during both wet and dry season, while we could not detect MCs in liver during the dry season. These results demonstrate that MC accumulation in liver and muscle of O. bonariensis occurred with different profiles. Moreover, different uptake, tissue distribution and excretion pathways may occur between diverse MC variants. For instance, during the dry season, an increase in the relative percentage of MC–LR in water samples was accompanied with an augmentation in the relative percentage of this toxin in muscle of O. bonariensis. Conversely, a rise in the relative percentage of MC–LA in water samples during the dry season did not impact on the distribution of this toxin in fish muscle. These results suggest the need of further studies on dynamics of different variants of MC to pursuit a complete evaluation of human health risk associated to MC occurrence.Fil: Amé, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Galanti, Lucas Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Menone, Mirta Lujan. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gerpe, Marcela Silvia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moreno, Victor Jorge. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; ArgentinaFil: Wunderlin, Daniel Alberto. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaElsevier Science2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96292Amé, María Valeria; Galanti, Lucas Nicolás; Menone, Mirta Lujan; Gerpe, Marcela Silvia; Moreno, Victor Jorge; et al.; Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina; Elsevier Science; Harmful Algae; 9; 1; 1-2010; 66-731568-9883CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1568988309000845info:eu-repo/semantics/altIdentifier/doi/10.1016/j.hal.2009.08.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:18Zoai:ri.conicet.gov.ar:11336/96292instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:18.55CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
title Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
spellingShingle Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
Amé, María Valeria
Bioaccumulation
Cyanotoxins
Fish
LCMS/MS
title_short Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
title_full Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
title_fullStr Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
title_full_unstemmed Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
title_sort Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina
dc.creator.none.fl_str_mv Amé, María Valeria
Galanti, Lucas Nicolás
Menone, Mirta Lujan
Gerpe, Marcela Silvia
Moreno, Victor Jorge
Wunderlin, Daniel Alberto
author Amé, María Valeria
author_facet Amé, María Valeria
Galanti, Lucas Nicolás
Menone, Mirta Lujan
Gerpe, Marcela Silvia
Moreno, Victor Jorge
Wunderlin, Daniel Alberto
author_role author
author2 Galanti, Lucas Nicolás
Menone, Mirta Lujan
Gerpe, Marcela Silvia
Moreno, Victor Jorge
Wunderlin, Daniel Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Bioaccumulation
Cyanotoxins
Fish
LCMS/MS
topic Bioaccumulation
Cyanotoxins
Fish
LCMS/MS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.5
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We evaluated the presence of four common microcystins (MC–LR, –RR, –YR and –LA) in water samples and tissues (liver and muscle) of Odontesthes bonariensis collected in Los Padres Lake (Argentina). MCs were quantified by HPLC–ESI-MS/MS. The total content of MCs in water samples (2.8 ± 5.6 μg L−1) and in O. bonariensis muscle (3.9 ± 2.2 μg kg−1) never surpassed guidelines values recommended by WHO for either recreational use of water or fish consumption. The total content of MCs in O. bonariensis liver was 33.6 ± 37.2 μg kg−1. However, we observed both spatial and temporal changes in MC profile, suggesting the need of an intensive monitoring program at such lake to ensure the health of people living in its surrounding. We observed a significant correlation between the content of total and dissolved MC in water and the concentration of these toxins in liver, showing the probable uptake of dissolved MC by O. bonariensis. MC–RR was the dominant variant in water samples, followed by MC–LA and MC–LR. MC–YR was always present in water samples, but in the lowest concentrations of the congeners measured. MC content in liver in O. bonariensis was ten-fold higher than the corresponding content in fish muscle. However, MCs were present in muscle of O. bonariensis during both wet and dry season, while we could not detect MCs in liver during the dry season. These results demonstrate that MC accumulation in liver and muscle of O. bonariensis occurred with different profiles. Moreover, different uptake, tissue distribution and excretion pathways may occur between diverse MC variants. For instance, during the dry season, an increase in the relative percentage of MC–LR in water samples was accompanied with an augmentation in the relative percentage of this toxin in muscle of O. bonariensis. Conversely, a rise in the relative percentage of MC–LA in water samples during the dry season did not impact on the distribution of this toxin in fish muscle. These results suggest the need of further studies on dynamics of different variants of MC to pursuit a complete evaluation of human health risk associated to MC occurrence.
Fil: Amé, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Galanti, Lucas Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Menone, Mirta Lujan. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerpe, Marcela Silvia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moreno, Victor Jorge. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina
Fil: Wunderlin, Daniel Alberto. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description We evaluated the presence of four common microcystins (MC–LR, –RR, –YR and –LA) in water samples and tissues (liver and muscle) of Odontesthes bonariensis collected in Los Padres Lake (Argentina). MCs were quantified by HPLC–ESI-MS/MS. The total content of MCs in water samples (2.8 ± 5.6 μg L−1) and in O. bonariensis muscle (3.9 ± 2.2 μg kg−1) never surpassed guidelines values recommended by WHO for either recreational use of water or fish consumption. The total content of MCs in O. bonariensis liver was 33.6 ± 37.2 μg kg−1. However, we observed both spatial and temporal changes in MC profile, suggesting the need of an intensive monitoring program at such lake to ensure the health of people living in its surrounding. We observed a significant correlation between the content of total and dissolved MC in water and the concentration of these toxins in liver, showing the probable uptake of dissolved MC by O. bonariensis. MC–RR was the dominant variant in water samples, followed by MC–LA and MC–LR. MC–YR was always present in water samples, but in the lowest concentrations of the congeners measured. MC content in liver in O. bonariensis was ten-fold higher than the corresponding content in fish muscle. However, MCs were present in muscle of O. bonariensis during both wet and dry season, while we could not detect MCs in liver during the dry season. These results demonstrate that MC accumulation in liver and muscle of O. bonariensis occurred with different profiles. Moreover, different uptake, tissue distribution and excretion pathways may occur between diverse MC variants. For instance, during the dry season, an increase in the relative percentage of MC–LR in water samples was accompanied with an augmentation in the relative percentage of this toxin in muscle of O. bonariensis. Conversely, a rise in the relative percentage of MC–LA in water samples during the dry season did not impact on the distribution of this toxin in fish muscle. These results suggest the need of further studies on dynamics of different variants of MC to pursuit a complete evaluation of human health risk associated to MC occurrence.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96292
Amé, María Valeria; Galanti, Lucas Nicolás; Menone, Mirta Lujan; Gerpe, Marcela Silvia; Moreno, Victor Jorge; et al.; Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina; Elsevier Science; Harmful Algae; 9; 1; 1-2010; 66-73
1568-9883
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96292
identifier_str_mv Amé, María Valeria; Galanti, Lucas Nicolás; Menone, Mirta Lujan; Gerpe, Marcela Silvia; Moreno, Victor Jorge; et al.; Microcystin-LR, -RR, -YR and -LA in water samples and fishes from a shallow lake in Argentina; Elsevier Science; Harmful Algae; 9; 1; 1-2010; 66-73
1568-9883
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1568988309000845
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.hal.2009.08.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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