Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
- Autores
- Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations.
Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina - Materia
-
Baso-Lateral Amygdala
Conflictive Environment
Histamine
Lateralization
Lidocaine - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/80344
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamineAlvarez Toro, Edgardo OrozimboBanzan, Arturo MartinBaso-Lateral AmygdalaConflictive EnvironmentHistamineLateralizationLidocainehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations.Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; ArgentinaElsevier Science2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80344Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin; Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine; Elsevier Science; Behavioural Brain Research; 218; 1; 3-2011; 158-1640166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2010.11.024info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432810007485info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:00Zoai:ri.conicet.gov.ar:11336/80344instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:01.085CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
title |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
spellingShingle |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine Alvarez Toro, Edgardo Orozimbo Baso-Lateral Amygdala Conflictive Environment Histamine Lateralization Lidocaine |
title_short |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
title_full |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
title_fullStr |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
title_full_unstemmed |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
title_sort |
Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine |
dc.creator.none.fl_str_mv |
Alvarez Toro, Edgardo Orozimbo Banzan, Arturo Martin |
author |
Alvarez Toro, Edgardo Orozimbo |
author_facet |
Alvarez Toro, Edgardo Orozimbo Banzan, Arturo Martin |
author_role |
author |
author2 |
Banzan, Arturo Martin |
author2_role |
author |
dc.subject.none.fl_str_mv |
Baso-Lateral Amygdala Conflictive Environment Histamine Lateralization Lidocaine |
topic |
Baso-Lateral Amygdala Conflictive Environment Histamine Lateralization Lidocaine |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations. Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina |
description |
Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/80344 Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin; Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine; Elsevier Science; Behavioural Brain Research; 218; 1; 3-2011; 158-164 0166-4328 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/80344 |
identifier_str_mv |
Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin; Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine; Elsevier Science; Behavioural Brain Research; 218; 1; 3-2011; 158-164 0166-4328 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2010.11.024 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432810007485 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613200158392320 |
score |
13.070432 |