Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine

Autores
Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations.
Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Materia
Baso-Lateral Amygdala
Conflictive Environment
Histamine
Lateralization
Lidocaine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80344

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spelling Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamineAlvarez Toro, Edgardo OrozimboBanzan, Arturo MartinBaso-Lateral AmygdalaConflictive EnvironmentHistamineLateralizationLidocainehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations.Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; ArgentinaElsevier Science2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80344Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin; Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine; Elsevier Science; Behavioural Brain Research; 218; 1; 3-2011; 158-1640166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2010.11.024info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432810007485info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:00Zoai:ri.conicet.gov.ar:11336/80344instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:01.085CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
title Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
spellingShingle Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
Alvarez Toro, Edgardo Orozimbo
Baso-Lateral Amygdala
Conflictive Environment
Histamine
Lateralization
Lidocaine
title_short Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
title_full Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
title_fullStr Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
title_full_unstemmed Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
title_sort Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine
dc.creator.none.fl_str_mv Alvarez Toro, Edgardo Orozimbo
Banzan, Arturo Martin
author Alvarez Toro, Edgardo Orozimbo
author_facet Alvarez Toro, Edgardo Orozimbo
Banzan, Arturo Martin
author_role author
author2 Banzan, Arturo Martin
author2_role author
dc.subject.none.fl_str_mv Baso-Lateral Amygdala
Conflictive Environment
Histamine
Lateralization
Lidocaine
topic Baso-Lateral Amygdala
Conflictive Environment
Histamine
Lateralization
Lidocaine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations.
Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
description Functional laterality appears to be present in many brain functions in man and animals. The existence of paired neural circuits which act differentially to modulate a specific behavioural function seems to be an evolutionary successful strategy in animal evolution. In spite of many examples described in mammals, birds and other vertebrates and invertebrates, still its intrinsic mechanism is not completely understood. In this work the participation of the baso-lateral amygdala (BLA) on lateralized motivated exploratory behaviour and the possible influence of histamine neurons in these mechanisms were studied in rats. Different groups of animals under xylacine-ketamine anesthesia were implanted with microinjection guide cannulae into the right or left BLA. 72. h after implantation, animals were tested in hole-board cage (OVM) with a novelty object positioned in the center of the arena, as a model of exploration of a non-conflictive environment, and 24. h later they were tested in the Elevated Asymmetric Plus Maze (APM) as a model of conflictive exploration. In the day of the experiment, lidocaine was applied into the left, or right BLA in order to block the electrical activity of BLA neurons. Saline in the contralateral BLA was considered control. Results showed that exploratory activity in the OVM was significantly inhibited when lidocaine was microinjected into the left BLA, and no changes were observed when lidocaine was applied into the right BLA. When histamine was microinjected into the right BLA and lidocaine into the contralateral BLA, head-dipping, rearing, and focalized exploration behaviour were significantly inhibited. In the APM, lidocaine treatment increased equally the exploration of the " single wall" and " high and low walls" arms of the labyrinth, independently if blocking of electrical activity of the BLA neurons was performed in the left or right amygdala. Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA. In conclusion, present evidence support the lateralized participation of the amygdala on exploratory behaviour and histamine neurons appear to mediate part of these differential modulations.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80344
Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin; Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine; Elsevier Science; Behavioural Brain Research; 218; 1; 3-2011; 158-164
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80344
identifier_str_mv Alvarez Toro, Edgardo Orozimbo; Banzan, Arturo Martin; Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: Role of histamine; Elsevier Science; Behavioural Brain Research; 218; 1; 3-2011; 158-164
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2010.11.024
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432810007485
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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