Activation of peripheral blood neutrophils from patients with active advanced tuberculosis

Autores
de la Barrera, Silvia Susana; Sasiain, María del Carmen; Alemán, Mercedes; Beigier Bompadre, Macarena; Borghetti, Claudio; Abbate, Pablo Eduardo; Isturiz, Martín Amadeo
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Activation of peripheral blood neutrophils (PMN) was investigated in order to determine whether they might contribute to the inflammatory process during active advanced tuberculosis. Receptors for the Fc portion of IgG (FcγR) (FcγRI, FcγRII, and FcγRIIIB), CD66 (degranulation marker), and receptors for tumor necrosis factor-α (TNF-R55 and TNF-R75) were analyzed on PMN obtained from normal controls and tuberculosis patients (TB-PMN). Functional parameters such as cytotoxicity, superoxide anion generation triggered by N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), and TNF-α and IL-1β production were evaluated. A high expression of TNF-R55, CD66, and FcγRIIIB and the appearance of FcγRI were detected in TB-PMN. In addition, cytotoxicity, superoxide anion release, and TNF-α and IL-1β production were enhanced in TB-PMN. Thus, in tuberculosis, the activation of PMN outside the focus of infection strongly suggests the possibility of a systemic inflammation that could modulate the inflammatory response.
Fil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Sasiain, María del Carmen. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alemán, Mercedes. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Beigier Bompadre, Macarena. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Borghetti, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; Argentina
Fil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; Argentina
Fil: Isturiz, Martín Amadeo. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Neutrophils
Tuberculosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54743
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/54743
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Activation of peripheral blood neutrophils from patients with active advanced tuberculosisde la Barrera, Silvia SusanaSasiain, María del CarmenAlemán, MercedesBeigier Bompadre, MacarenaBorghetti, ClaudioAbbate, Pablo EduardoIsturiz, Martín AmadeoNeutrophilsTuberculosishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Activation of peripheral blood neutrophils (PMN) was investigated in order to determine whether they might contribute to the inflammatory process during active advanced tuberculosis. Receptors for the Fc portion of IgG (FcγR) (FcγRI, FcγRII, and FcγRIIIB), CD66 (degranulation marker), and receptors for tumor necrosis factor-α (TNF-R55 and TNF-R75) were analyzed on PMN obtained from normal controls and tuberculosis patients (TB-PMN). Functional parameters such as cytotoxicity, superoxide anion generation triggered by N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), and TNF-α and IL-1β production were evaluated. A high expression of TNF-R55, CD66, and FcγRIIIB and the appearance of FcγRI were detected in TB-PMN. In addition, cytotoxicity, superoxide anion release, and TNF-α and IL-1β production were enhanced in TB-PMN. Thus, in tuberculosis, the activation of PMN outside the focus of infection strongly suggests the possibility of a systemic inflammation that could modulate the inflammatory response.Fil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Sasiain, María del Carmen. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alemán, Mercedes. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Beigier Bompadre, Macarena. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Borghetti, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; ArgentinaFil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; ArgentinaFil: Isturiz, Martín Amadeo. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcademic Press Inc Elsevier Science2001-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54743de la Barrera, Silvia Susana; Sasiain, María del Carmen; Alemán, Mercedes; Beigier Bompadre, Macarena; Borghetti, Claudio; et al.; Activation of peripheral blood neutrophils from patients with active advanced tuberculosis; Academic Press Inc Elsevier Science; Clinical Immunology; 100; 1; 11-2001; 87-951521-66161521-7035CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1521661601950442info:eu-repo/semantics/altIdentifier/doi/10.1006/clim.2001.5044info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:06Zoai:ri.conicet.gov.ar:11336/54743instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:06.849CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
title Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
spellingShingle Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
de la Barrera, Silvia Susana
Neutrophils
Tuberculosis
title_short Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
title_full Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
title_fullStr Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
title_full_unstemmed Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
title_sort Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
dc.creator.none.fl_str_mv de la Barrera, Silvia Susana
Sasiain, María del Carmen
Alemán, Mercedes
Beigier Bompadre, Macarena
Borghetti, Claudio
Abbate, Pablo Eduardo
Isturiz, Martín Amadeo
author de la Barrera, Silvia Susana
author_facet de la Barrera, Silvia Susana
Sasiain, María del Carmen
Alemán, Mercedes
Beigier Bompadre, Macarena
Borghetti, Claudio
Abbate, Pablo Eduardo
Isturiz, Martín Amadeo
author_role author
author2 Sasiain, María del Carmen
Alemán, Mercedes
Beigier Bompadre, Macarena
Borghetti, Claudio
Abbate, Pablo Eduardo
Isturiz, Martín Amadeo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neutrophils
Tuberculosis
topic Neutrophils
Tuberculosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Activation of peripheral blood neutrophils (PMN) was investigated in order to determine whether they might contribute to the inflammatory process during active advanced tuberculosis. Receptors for the Fc portion of IgG (FcγR) (FcγRI, FcγRII, and FcγRIIIB), CD66 (degranulation marker), and receptors for tumor necrosis factor-α (TNF-R55 and TNF-R75) were analyzed on PMN obtained from normal controls and tuberculosis patients (TB-PMN). Functional parameters such as cytotoxicity, superoxide anion generation triggered by N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), and TNF-α and IL-1β production were evaluated. A high expression of TNF-R55, CD66, and FcγRIIIB and the appearance of FcγRI were detected in TB-PMN. In addition, cytotoxicity, superoxide anion release, and TNF-α and IL-1β production were enhanced in TB-PMN. Thus, in tuberculosis, the activation of PMN outside the focus of infection strongly suggests the possibility of a systemic inflammation that could modulate the inflammatory response.
Fil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Sasiain, María del Carmen. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alemán, Mercedes. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Beigier Bompadre, Macarena. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Borghetti, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; Argentina
Fil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; Argentina
Fil: Isturiz, Martín Amadeo. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Activation of peripheral blood neutrophils (PMN) was investigated in order to determine whether they might contribute to the inflammatory process during active advanced tuberculosis. Receptors for the Fc portion of IgG (FcγR) (FcγRI, FcγRII, and FcγRIIIB), CD66 (degranulation marker), and receptors for tumor necrosis factor-α (TNF-R55 and TNF-R75) were analyzed on PMN obtained from normal controls and tuberculosis patients (TB-PMN). Functional parameters such as cytotoxicity, superoxide anion generation triggered by N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), and TNF-α and IL-1β production were evaluated. A high expression of TNF-R55, CD66, and FcγRIIIB and the appearance of FcγRI were detected in TB-PMN. In addition, cytotoxicity, superoxide anion release, and TNF-α and IL-1β production were enhanced in TB-PMN. Thus, in tuberculosis, the activation of PMN outside the focus of infection strongly suggests the possibility of a systemic inflammation that could modulate the inflammatory response.
publishDate 2001
dc.date.none.fl_str_mv 2001-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54743
de la Barrera, Silvia Susana; Sasiain, María del Carmen; Alemán, Mercedes; Beigier Bompadre, Macarena; Borghetti, Claudio; et al.; Activation of peripheral blood neutrophils from patients with active advanced tuberculosis; Academic Press Inc Elsevier Science; Clinical Immunology; 100; 1; 11-2001; 87-95
1521-6616
1521-7035
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54743
identifier_str_mv de la Barrera, Silvia Susana; Sasiain, María del Carmen; Alemán, Mercedes; Beigier Bompadre, Macarena; Borghetti, Claudio; et al.; Activation of peripheral blood neutrophils from patients with active advanced tuberculosis; Academic Press Inc Elsevier Science; Clinical Immunology; 100; 1; 11-2001; 87-95
1521-6616
1521-7035
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1521661601950442
info:eu-repo/semantics/altIdentifier/doi/10.1006/clim.2001.5044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981040331685888
score 12.48226

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