Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm

Autores
Torrezan Nitao, Elis; Guidobaldi, Héctor Alejandro; Giojalas, Laura Cecilia; Barratt, Christopher; Publicover, Stephen
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A human sperm must swim to the egg to fertilise it. To do this the sperm uses different types of swimming (behaviours) as they are needed. When we watch sperm swimming we see that they regularly change behaviour, sometimes repeatedly switching between two different types. Calcium ions inside cells are crucial in controlling many cell functions and in sperm they play a key role in regulating their behaviour. Here we have measured the concentration of calcium ions inside swimming human sperm. We found that in 12/35 (34%) of the cells we assessed, the concentration of calcium changed repeatedly, averaging more than one cycle of rise and fall per minute. These changes in the concentration of calcium ions occurred as the sperm switched swimming stroke, suggesting that oscillation of calcium concentration is involved in controlling the switching of sperm behaviour. Impaired sperm motility is an important cause of subfertility in men. Understanding how sperm behaviour is controlled will allow the development of treatments that can rescue the fertility of sperm with impaired motility.
Fil: Torrezan Nitao, Elis. University of Birmingham; Reino Unido
Fil: Guidobaldi, Héctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: Giojalas, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: Barratt, Christopher. University of Dundee; Reino Unido
Fil: Publicover, Stephen. University of Birmingham; Reino Unido
Materia
SPERM
HUMAN
CALCIUM
HYPERACTIVATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/134825
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human spermTorrezan Nitao, ElisGuidobaldi, Héctor AlejandroGiojalas, Laura CeciliaBarratt, ChristopherPublicover, StephenSPERMHUMANCALCIUMHYPERACTIVATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A human sperm must swim to the egg to fertilise it. To do this the sperm uses different types of swimming (behaviours) as they are needed. When we watch sperm swimming we see that they regularly change behaviour, sometimes repeatedly switching between two different types. Calcium ions inside cells are crucial in controlling many cell functions and in sperm they play a key role in regulating their behaviour. Here we have measured the concentration of calcium ions inside swimming human sperm. We found that in 12/35 (34%) of the cells we assessed, the concentration of calcium changed repeatedly, averaging more than one cycle of rise and fall per minute. These changes in the concentration of calcium ions occurred as the sperm switched swimming stroke, suggesting that oscillation of calcium concentration is involved in controlling the switching of sperm behaviour. Impaired sperm motility is an important cause of subfertility in men. Understanding how sperm behaviour is controlled will allow the development of treatments that can rescue the fertility of sperm with impaired motility.Fil: Torrezan Nitao, Elis. University of Birmingham; Reino UnidoFil: Guidobaldi, Héctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; ArgentinaFil: Giojalas, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; ArgentinaFil: Barratt, Christopher. University of Dundee; Reino UnidoFil: Publicover, Stephen. University of Birmingham; Reino UnidoBioScientifica2021-03-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134825Torrezan Nitao, Elis; Guidobaldi, Héctor Alejandro; Giojalas, Laura Cecilia; Barratt, Christopher; Publicover, Stephen; Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm; BioScientifica; Reproduction and Fertility; 2; 1; 9-3-2021; 5-72633-8386CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://raf.bioscientifica.com/view/journals/raf/2/1/RAF-21-0001.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1530/RAF-21-0001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:27Zoai:ri.conicet.gov.ar:11336/134825instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:27.21CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
title Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
spellingShingle Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
Torrezan Nitao, Elis
SPERM
HUMAN
CALCIUM
HYPERACTIVATION
title_short Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
title_full Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
title_fullStr Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
title_full_unstemmed Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
title_sort Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
dc.creator.none.fl_str_mv Torrezan Nitao, Elis
Guidobaldi, Héctor Alejandro
Giojalas, Laura Cecilia
Barratt, Christopher
Publicover, Stephen
author Torrezan Nitao, Elis
author_facet Torrezan Nitao, Elis
Guidobaldi, Héctor Alejandro
Giojalas, Laura Cecilia
Barratt, Christopher
Publicover, Stephen
author_role author
author2 Guidobaldi, Héctor Alejandro
Giojalas, Laura Cecilia
Barratt, Christopher
Publicover, Stephen
author2_role author
author
author
author
dc.subject.none.fl_str_mv SPERM
HUMAN
CALCIUM
HYPERACTIVATION
topic SPERM
HUMAN
CALCIUM
HYPERACTIVATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A human sperm must swim to the egg to fertilise it. To do this the sperm uses different types of swimming (behaviours) as they are needed. When we watch sperm swimming we see that they regularly change behaviour, sometimes repeatedly switching between two different types. Calcium ions inside cells are crucial in controlling many cell functions and in sperm they play a key role in regulating their behaviour. Here we have measured the concentration of calcium ions inside swimming human sperm. We found that in 12/35 (34%) of the cells we assessed, the concentration of calcium changed repeatedly, averaging more than one cycle of rise and fall per minute. These changes in the concentration of calcium ions occurred as the sperm switched swimming stroke, suggesting that oscillation of calcium concentration is involved in controlling the switching of sperm behaviour. Impaired sperm motility is an important cause of subfertility in men. Understanding how sperm behaviour is controlled will allow the development of treatments that can rescue the fertility of sperm with impaired motility.
Fil: Torrezan Nitao, Elis. University of Birmingham; Reino Unido
Fil: Guidobaldi, Héctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: Giojalas, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: Barratt, Christopher. University of Dundee; Reino Unido
Fil: Publicover, Stephen. University of Birmingham; Reino Unido
description A human sperm must swim to the egg to fertilise it. To do this the sperm uses different types of swimming (behaviours) as they are needed. When we watch sperm swimming we see that they regularly change behaviour, sometimes repeatedly switching between two different types. Calcium ions inside cells are crucial in controlling many cell functions and in sperm they play a key role in regulating their behaviour. Here we have measured the concentration of calcium ions inside swimming human sperm. We found that in 12/35 (34%) of the cells we assessed, the concentration of calcium changed repeatedly, averaging more than one cycle of rise and fall per minute. These changes in the concentration of calcium ions occurred as the sperm switched swimming stroke, suggesting that oscillation of calcium concentration is involved in controlling the switching of sperm behaviour. Impaired sperm motility is an important cause of subfertility in men. Understanding how sperm behaviour is controlled will allow the development of treatments that can rescue the fertility of sperm with impaired motility.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/134825
Torrezan Nitao, Elis; Guidobaldi, Héctor Alejandro; Giojalas, Laura Cecilia; Barratt, Christopher; Publicover, Stephen; Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm; BioScientifica; Reproduction and Fertility; 2; 1; 9-3-2021; 5-7
2633-8386
CONICET Digital
CONICET
url http://hdl.handle.net/11336/134825
identifier_str_mv Torrezan Nitao, Elis; Guidobaldi, Héctor Alejandro; Giojalas, Laura Cecilia; Barratt, Christopher; Publicover, Stephen; Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm; BioScientifica; Reproduction and Fertility; 2; 1; 9-3-2021; 5-7
2633-8386
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://raf.bioscientifica.com/view/journals/raf/2/1/RAF-21-0001.xml
info:eu-repo/semantics/altIdentifier/doi/10.1530/RAF-21-0001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioScientifica
publisher.none.fl_str_mv BioScientifica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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