Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model

Autores
Blanco, Paula Graciela; Vercellini, Maria del Rosario; Rube, Ana Maria; Rodríguez, Raúl Ricardo; Arias, Daniel Osvaldo; Gobello, María Cristina
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to describe resistance index (RI) and systolic/diastolic ratio (S/D ratio) of uterine and umbilical arteries in an experimental model of abnormal feline pregnancy pharmacologically induced. On Day 30 to 35 (32 ± 2.9) after mating, twenty domestic short-hair pregnant queens were randomly assigned to one of the following treatment groups: a treated group (TG; n = 8), which received 10 mg/kg of aglepristone SC twice, 24 h apart and a control non-treated group (CG; n = 12). M-Mode and Doppler ultrasonographic evaluations were performed at the initiation of the treatment (Day 0) and then every other day during 8 days (i.e. Days 32, 34, 36, 38 and 40 of gestation) para mi esto no va x q x ej para q empeiza el d 35 estarian mal los dias??. In both groups, uterine and umbilical arteries were evaluated by Doppler ultrasound while fetal heart rate (FHR) was assessed by M-Mode ultrasound. Resistance index of uterine artery augmented in TG from Day 2 onwards, conversely it decreased in CG (P< 0.01). On Day 8, RI values were 0.64 ± 0.05 vs. 0.37 ± 0.01 for TG and CG, respectively. Additionally, S/D ratio of the same artery presented an increase in TG, while this ratio diminished in CG (P< 0.01). On Day 8, this parameter showed values of 2.98 ± 0.4 vs. 1.62 ± 0.06 for TG and CG, respectively. Resistance index of umbilical artery remained almost unchanged in TG from Day 6 onwards, while it progressively decreased in CG throughout the course of the study (P< 0.05). On Day 8, RI were 0.89 ± 0.04 and 0.82 ± 0.01, for TG and CG, respectively. Furthermore on Day 8, S/D ratio of umbilical artery progressively diminished in CG but not in TG (P< 0.01), being 14.7 ± 9.1 vs. 5.9 ± 0.3 for TG and CG, respectively. Fetal heart rate was higher in TG than in CG (P< 0.05). Group differences in Doppler parameters appeared as early as 48 hours after abortion treatment, when the other clinical or ultrasonographic signs were still absent. It is concluded that uterine and umbilical arteries blood flow differed between these normal and induced abnormal cat gestations predicting an adverse obstetric outcome.
Fil: Blanco, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Vercellini, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Rube, Ana Maria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Rodríguez, Raúl Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Arias, Daniel Osvaldo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
ULTRASOUND
DOPPLER
CAT
PREGNANCY
ABORTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114736
Acceder
id CONICETDig_d7c64705d7db352cb461d60b91589302
oai_identifier_str oai:ri.conicet.gov.ar:11336/114736
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation modelBlanco, Paula GracielaVercellini, Maria del RosarioRube, Ana MariaRodríguez, Raúl RicardoArias, Daniel OsvaldoGobello, María CristinaULTRASOUNDDOPPLERCATPREGNANCYABORTIONhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of this study was to describe resistance index (RI) and systolic/diastolic ratio (S/D ratio) of uterine and umbilical arteries in an experimental model of abnormal feline pregnancy pharmacologically induced. On Day 30 to 35 (32 ± 2.9) after mating, twenty domestic short-hair pregnant queens were randomly assigned to one of the following treatment groups: a treated group (TG; n = 8), which received 10 mg/kg of aglepristone SC twice, 24 h apart and a control non-treated group (CG; n = 12). M-Mode and Doppler ultrasonographic evaluations were performed at the initiation of the treatment (Day 0) and then every other day during 8 days (i.e. Days 32, 34, 36, 38 and 40 of gestation) para mi esto no va x q x ej para q empeiza el d 35 estarian mal los dias??. In both groups, uterine and umbilical arteries were evaluated by Doppler ultrasound while fetal heart rate (FHR) was assessed by M-Mode ultrasound. Resistance index of uterine artery augmented in TG from Day 2 onwards, conversely it decreased in CG (P< 0.01). On Day 8, RI values were 0.64 ± 0.05 vs. 0.37 ± 0.01 for TG and CG, respectively. Additionally, S/D ratio of the same artery presented an increase in TG, while this ratio diminished in CG (P< 0.01). On Day 8, this parameter showed values of 2.98 ± 0.4 vs. 1.62 ± 0.06 for TG and CG, respectively. Resistance index of umbilical artery remained almost unchanged in TG from Day 6 onwards, while it progressively decreased in CG throughout the course of the study (P< 0.05). On Day 8, RI were 0.89 ± 0.04 and 0.82 ± 0.01, for TG and CG, respectively. Furthermore on Day 8, S/D ratio of umbilical artery progressively diminished in CG but not in TG (P< 0.01), being 14.7 ± 9.1 vs. 5.9 ± 0.3 for TG and CG, respectively. Fetal heart rate was higher in TG than in CG (P< 0.05). Group differences in Doppler parameters appeared as early as 48 hours after abortion treatment, when the other clinical or ultrasonographic signs were still absent. It is concluded that uterine and umbilical arteries blood flow differed between these normal and induced abnormal cat gestations predicting an adverse obstetric outcome.Fil: Blanco, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Vercellini, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Rube, Ana Maria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Rodríguez, Raúl Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Arias, Daniel Osvaldo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaElsevier Science Inc2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114736Blanco, Paula Graciela; Vercellini, Maria del Rosario; Rube, Ana Maria; Rodríguez, Raúl Ricardo; Arias, Daniel Osvaldo; et al.; Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model; Elsevier Science Inc; Theriogenology; 86; 9; 12-2016; 2323-23270093-691XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0093691X16303375?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.theriogenology.2016.07.028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:52Zoai:ri.conicet.gov.ar:11336/114736instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:52.711CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
title Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
spellingShingle Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
Blanco, Paula Graciela
ULTRASOUND
DOPPLER
CAT
PREGNANCY
ABORTION
title_short Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
title_full Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
title_fullStr Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
title_full_unstemmed Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
title_sort Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model
dc.creator.none.fl_str_mv Blanco, Paula Graciela
Vercellini, Maria del Rosario
Rube, Ana Maria
Rodríguez, Raúl Ricardo
Arias, Daniel Osvaldo
Gobello, María Cristina
author Blanco, Paula Graciela
author_facet Blanco, Paula Graciela
Vercellini, Maria del Rosario
Rube, Ana Maria
Rodríguez, Raúl Ricardo
Arias, Daniel Osvaldo
Gobello, María Cristina
author_role author
author2 Vercellini, Maria del Rosario
Rube, Ana Maria
Rodríguez, Raúl Ricardo
Arias, Daniel Osvaldo
Gobello, María Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ULTRASOUND
DOPPLER
CAT
PREGNANCY
ABORTION
topic ULTRASOUND
DOPPLER
CAT
PREGNANCY
ABORTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The aim of this study was to describe resistance index (RI) and systolic/diastolic ratio (S/D ratio) of uterine and umbilical arteries in an experimental model of abnormal feline pregnancy pharmacologically induced. On Day 30 to 35 (32 ± 2.9) after mating, twenty domestic short-hair pregnant queens were randomly assigned to one of the following treatment groups: a treated group (TG; n = 8), which received 10 mg/kg of aglepristone SC twice, 24 h apart and a control non-treated group (CG; n = 12). M-Mode and Doppler ultrasonographic evaluations were performed at the initiation of the treatment (Day 0) and then every other day during 8 days (i.e. Days 32, 34, 36, 38 and 40 of gestation) para mi esto no va x q x ej para q empeiza el d 35 estarian mal los dias??. In both groups, uterine and umbilical arteries were evaluated by Doppler ultrasound while fetal heart rate (FHR) was assessed by M-Mode ultrasound. Resistance index of uterine artery augmented in TG from Day 2 onwards, conversely it decreased in CG (P< 0.01). On Day 8, RI values were 0.64 ± 0.05 vs. 0.37 ± 0.01 for TG and CG, respectively. Additionally, S/D ratio of the same artery presented an increase in TG, while this ratio diminished in CG (P< 0.01). On Day 8, this parameter showed values of 2.98 ± 0.4 vs. 1.62 ± 0.06 for TG and CG, respectively. Resistance index of umbilical artery remained almost unchanged in TG from Day 6 onwards, while it progressively decreased in CG throughout the course of the study (P< 0.05). On Day 8, RI were 0.89 ± 0.04 and 0.82 ± 0.01, for TG and CG, respectively. Furthermore on Day 8, S/D ratio of umbilical artery progressively diminished in CG but not in TG (P< 0.01), being 14.7 ± 9.1 vs. 5.9 ± 0.3 for TG and CG, respectively. Fetal heart rate was higher in TG than in CG (P< 0.05). Group differences in Doppler parameters appeared as early as 48 hours after abortion treatment, when the other clinical or ultrasonographic signs were still absent. It is concluded that uterine and umbilical arteries blood flow differed between these normal and induced abnormal cat gestations predicting an adverse obstetric outcome.
Fil: Blanco, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Vercellini, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Rube, Ana Maria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Rodríguez, Raúl Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Arias, Daniel Osvaldo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description The aim of this study was to describe resistance index (RI) and systolic/diastolic ratio (S/D ratio) of uterine and umbilical arteries in an experimental model of abnormal feline pregnancy pharmacologically induced. On Day 30 to 35 (32 ± 2.9) after mating, twenty domestic short-hair pregnant queens were randomly assigned to one of the following treatment groups: a treated group (TG; n = 8), which received 10 mg/kg of aglepristone SC twice, 24 h apart and a control non-treated group (CG; n = 12). M-Mode and Doppler ultrasonographic evaluations were performed at the initiation of the treatment (Day 0) and then every other day during 8 days (i.e. Days 32, 34, 36, 38 and 40 of gestation) para mi esto no va x q x ej para q empeiza el d 35 estarian mal los dias??. In both groups, uterine and umbilical arteries were evaluated by Doppler ultrasound while fetal heart rate (FHR) was assessed by M-Mode ultrasound. Resistance index of uterine artery augmented in TG from Day 2 onwards, conversely it decreased in CG (P< 0.01). On Day 8, RI values were 0.64 ± 0.05 vs. 0.37 ± 0.01 for TG and CG, respectively. Additionally, S/D ratio of the same artery presented an increase in TG, while this ratio diminished in CG (P< 0.01). On Day 8, this parameter showed values of 2.98 ± 0.4 vs. 1.62 ± 0.06 for TG and CG, respectively. Resistance index of umbilical artery remained almost unchanged in TG from Day 6 onwards, while it progressively decreased in CG throughout the course of the study (P< 0.05). On Day 8, RI were 0.89 ± 0.04 and 0.82 ± 0.01, for TG and CG, respectively. Furthermore on Day 8, S/D ratio of umbilical artery progressively diminished in CG but not in TG (P< 0.01), being 14.7 ± 9.1 vs. 5.9 ± 0.3 for TG and CG, respectively. Fetal heart rate was higher in TG than in CG (P< 0.05). Group differences in Doppler parameters appeared as early as 48 hours after abortion treatment, when the other clinical or ultrasonographic signs were still absent. It is concluded that uterine and umbilical arteries blood flow differed between these normal and induced abnormal cat gestations predicting an adverse obstetric outcome.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114736
Blanco, Paula Graciela; Vercellini, Maria del Rosario; Rube, Ana Maria; Rodríguez, Raúl Ricardo; Arias, Daniel Osvaldo; et al.; Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model; Elsevier Science Inc; Theriogenology; 86; 9; 12-2016; 2323-2327
0093-691X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114736
identifier_str_mv Blanco, Paula Graciela; Vercellini, Maria del Rosario; Rube, Ana Maria; Rodríguez, Raúl Ricardo; Arias, Daniel Osvaldo; et al.; Evaluation of feline uterine and umbilical arteries blood flow in a pharmacologically induced abnormal gestation model; Elsevier Science Inc; Theriogenology; 86; 9; 12-2016; 2323-2327
0093-691X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0093691X16303375?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.theriogenology.2016.07.028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268944018178048
score 13.13397

Publicaciones similares