Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas

Autores
Vara Messler, Marianela; Cremonezzi, David César; Soria, Elio Andres; Eynard, Aldo Renato
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Urinary tract tumors are tenth in frequency, and many environmental carcinogens are excreted by urine. Interplay between chronic inflammatory urolithiasis and urothelial carcinogenesis is not well understood. Experimental evidences show that dietary melamine induce these events even at low concentrations. This is important because thousands of children were exposed to melamine through intentionally contaminated milk formula worldwide. We propose that an increased risk for urinary tumors in adult life may occur and screenings for early urinary signs may be necessary. Therefore, urothelial biology, melamine carcinogenic potential, and related epidemiology are discussed, recommending a preventive dietary polyunsaturated fatty acid-based supplementation, since they modulate such interplay in rodents.
Fil: Vara Messler, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Cremonezzi, David César. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina
Fil: Soria, Elio Andres. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
CANCER
LIPIDS
MELAMINE
TOXICOLOGY
URINARY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268821
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk FormulasVara Messler, MarianelaCremonezzi, David CésarSoria, Elio AndresEynard, Aldo RenatoCANCERLIPIDSMELAMINETOXICOLOGYURINARYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Urinary tract tumors are tenth in frequency, and many environmental carcinogens are excreted by urine. Interplay between chronic inflammatory urolithiasis and urothelial carcinogenesis is not well understood. Experimental evidences show that dietary melamine induce these events even at low concentrations. This is important because thousands of children were exposed to melamine through intentionally contaminated milk formula worldwide. We propose that an increased risk for urinary tumors in adult life may occur and screenings for early urinary signs may be necessary. Therefore, urothelial biology, melamine carcinogenic potential, and related epidemiology are discussed, recommending a preventive dietary polyunsaturated fatty acid-based supplementation, since they modulate such interplay in rodents.Fil: Vara Messler, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Cremonezzi, David César. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; ArgentinaFil: Soria, Elio Andres. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaTaylor & Francis2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268821Vara Messler, Marianela; Cremonezzi, David César; Soria, Elio Andres; Eynard, Aldo Renato; Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas; Taylor & Francis; Journal Of Environmental Science And Health Part C-environmental Carcinogenesis & Ecotoxicology Reviews; 30; 2; 4-2012; 174-1871059-0501CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10590501.2012.684302info:eu-repo/semantics/altIdentifier/doi/10.1080/10590501.2012.684302info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:28:40Zoai:ri.conicet.gov.ar:11336/268821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:28:41.276CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
title Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
spellingShingle Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
Vara Messler, Marianela
CANCER
LIPIDS
MELAMINE
TOXICOLOGY
URINARY
title_short Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
title_full Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
title_fullStr Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
title_full_unstemmed Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
title_sort Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas
dc.creator.none.fl_str_mv Vara Messler, Marianela
Cremonezzi, David César
Soria, Elio Andres
Eynard, Aldo Renato
author Vara Messler, Marianela
author_facet Vara Messler, Marianela
Cremonezzi, David César
Soria, Elio Andres
Eynard, Aldo Renato
author_role author
author2 Cremonezzi, David César
Soria, Elio Andres
Eynard, Aldo Renato
author2_role author
author
author
dc.subject.none.fl_str_mv CANCER
LIPIDS
MELAMINE
TOXICOLOGY
URINARY
topic CANCER
LIPIDS
MELAMINE
TOXICOLOGY
URINARY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Urinary tract tumors are tenth in frequency, and many environmental carcinogens are excreted by urine. Interplay between chronic inflammatory urolithiasis and urothelial carcinogenesis is not well understood. Experimental evidences show that dietary melamine induce these events even at low concentrations. This is important because thousands of children were exposed to melamine through intentionally contaminated milk formula worldwide. We propose that an increased risk for urinary tumors in adult life may occur and screenings for early urinary signs may be necessary. Therefore, urothelial biology, melamine carcinogenic potential, and related epidemiology are discussed, recommending a preventive dietary polyunsaturated fatty acid-based supplementation, since they modulate such interplay in rodents.
Fil: Vara Messler, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Cremonezzi, David César. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina
Fil: Soria, Elio Andres. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Urinary tract tumors are tenth in frequency, and many environmental carcinogens are excreted by urine. Interplay between chronic inflammatory urolithiasis and urothelial carcinogenesis is not well understood. Experimental evidences show that dietary melamine induce these events even at low concentrations. This is important because thousands of children were exposed to melamine through intentionally contaminated milk formula worldwide. We propose that an increased risk for urinary tumors in adult life may occur and screenings for early urinary signs may be necessary. Therefore, urothelial biology, melamine carcinogenic potential, and related epidemiology are discussed, recommending a preventive dietary polyunsaturated fatty acid-based supplementation, since they modulate such interplay in rodents.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268821
Vara Messler, Marianela; Cremonezzi, David César; Soria, Elio Andres; Eynard, Aldo Renato; Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas; Taylor & Francis; Journal Of Environmental Science And Health Part C-environmental Carcinogenesis & Ecotoxicology Reviews; 30; 2; 4-2012; 174-187
1059-0501
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268821
identifier_str_mv Vara Messler, Marianela; Cremonezzi, David César; Soria, Elio Andres; Eynard, Aldo Renato; Nutritional Chemoprevention of Urinary Tract Tumors (UTT) Induced by Lithogenic Agents: Risk for UTT in Children Exposed to Melamine-Contaminated Milk Formulas; Taylor & Francis; Journal Of Environmental Science And Health Part C-environmental Carcinogenesis & Ecotoxicology Reviews; 30; 2; 4-2012; 174-187
1059-0501
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10590501.2012.684302
info:eu-repo/semantics/altIdentifier/doi/10.1080/10590501.2012.684302
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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