Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel

Autores
García García, Maria de Lourdes; Valdespino Gómez, Jose Luis; García Sancho, Cecilia; Mayar Maya, Maria Eugenia; Palacios Martínez, Manuel; Balandrano Campos, Susana; Escobar Gutiérrez, Alejandro; Peruga, Armando; Weissenbacher, Mercedes Crecencia; Daniels, Elaine
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background. This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+ lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected individuals in a tuberculosis endemic and high Bacillus Calmette-Guerin (BCG) coverage environment. Methods. Clients of four Mexico City HIV detection centres were screened for HIV-1 anti-bodies (ELISA or haemagglutination, Western Blot); reactivity to PPD (Mantoux PPD, 5TU RT-23), Candida (1:1000, 0.1 ml), and tetanus toxoid (10Lf, 0.1 ml); and CD4+ T cells. Active tuberculosis was excluded. Informed consent was obtained. Results. From 5130 clients 1168 subjects were enrolled; of these 801 (68.6%) were HIV positive. Reactivity to PPD among HIV-positive subjects was found in 174 (22%), 261 (32.6%), and 296 (37%), at PPD cutoff levels of ≥10 mm, ≥5 mm, and ≥2 mm as compared to 224 (61%) of 367 HIV-negative individuals' reactors to PPD (≥10 mm) (P<0.001). After exclusion of anergic individuals using two cutoff levels for cutaneous allergens (≤2 mm and ≤5 mm), PPD reactivity between HIV-infected and uninfected individuals continued to be significantly different. Only HIV-infected individuals with CD4+ T cells ≥500 cells/mm3 had similar reactivity to PPD as HIV-uninfected individuals. Variables associated with PPD reactivity were CD4+ T cell counts, BCG scar, HIV infection and age. Conclusions. PPD reactivity was useful to diagnose tuberculosis infection only among HIV-infected individuals with CD4+ counts ≥500 cells/mm3. Among individuals with lower counts, lowering cutoff levels or using anergy panel did not permit comparable reactivity as that observed among HIV-uninfected individuals.
Fil: García García, Maria de Lourdes. Instituto de Salud Pública; México
Fil: Valdespino Gómez, Jose Luis. Instituto de Salud Pública; México
Fil: García Sancho, Cecilia. Instituto de Salud Pública; México
Fil: Mayar Maya, Maria Eugenia. Instituto de Salud Pública; México
Fil: Palacios Martínez, Manuel. Instituto de Salud Pública; México
Fil: Balandrano Campos, Susana. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; México
Fil: Escobar Gutiérrez, Alejandro. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; México
Fil: Peruga, Armando. PanAmerican Health Organization; Estados Unidos
Fil: Weissenbacher, Mercedes Crecencia. PanAmerican Health Organization; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Daniels, Elaine. National Institutes of Health; Estados Unidos
Materia
Anergy
Bcg Vaccine
Cd4 Lymphocytes
Delayed-Type Hypersensitivity
Hiv
Tuberculin Test
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39231
Acceder
id CONICETDig_d63b8829500631c3c186ca41595dafd0
oai_identifier_str oai:ri.conicet.gov.ar:11336/39231
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panelGarcía García, Maria de LourdesValdespino Gómez, Jose LuisGarcía Sancho, CeciliaMayar Maya, Maria EugeniaPalacios Martínez, ManuelBalandrano Campos, SusanaEscobar Gutiérrez, AlejandroPeruga, ArmandoWeissenbacher, Mercedes CrecenciaDaniels, ElaineAnergyBcg VaccineCd4 LymphocytesDelayed-Type HypersensitivityHivTuberculin Testhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background. This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+ lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected individuals in a tuberculosis endemic and high Bacillus Calmette-Guerin (BCG) coverage environment. Methods. Clients of four Mexico City HIV detection centres were screened for HIV-1 anti-bodies (ELISA or haemagglutination, Western Blot); reactivity to PPD (Mantoux PPD, 5TU RT-23), Candida (1:1000, 0.1 ml), and tetanus toxoid (10Lf, 0.1 ml); and CD4+ T cells. Active tuberculosis was excluded. Informed consent was obtained. Results. From 5130 clients 1168 subjects were enrolled; of these 801 (68.6%) were HIV positive. Reactivity to PPD among HIV-positive subjects was found in 174 (22%), 261 (32.6%), and 296 (37%), at PPD cutoff levels of ≥10 mm, ≥5 mm, and ≥2 mm as compared to 224 (61%) of 367 HIV-negative individuals' reactors to PPD (≥10 mm) (P<0.001). After exclusion of anergic individuals using two cutoff levels for cutaneous allergens (≤2 mm and ≤5 mm), PPD reactivity between HIV-infected and uninfected individuals continued to be significantly different. Only HIV-infected individuals with CD4+ T cells ≥500 cells/mm3 had similar reactivity to PPD as HIV-uninfected individuals. Variables associated with PPD reactivity were CD4+ T cell counts, BCG scar, HIV infection and age. Conclusions. PPD reactivity was useful to diagnose tuberculosis infection only among HIV-infected individuals with CD4+ counts ≥500 cells/mm3. Among individuals with lower counts, lowering cutoff levels or using anergy panel did not permit comparable reactivity as that observed among HIV-uninfected individuals.Fil: García García, Maria de Lourdes. Instituto de Salud Pública; MéxicoFil: Valdespino Gómez, Jose Luis. Instituto de Salud Pública; MéxicoFil: García Sancho, Cecilia. Instituto de Salud Pública; MéxicoFil: Mayar Maya, Maria Eugenia. Instituto de Salud Pública; MéxicoFil: Palacios Martínez, Manuel. Instituto de Salud Pública; MéxicoFil: Balandrano Campos, Susana. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Escobar Gutiérrez, Alejandro. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Peruga, Armando. PanAmerican Health Organization; Estados UnidosFil: Weissenbacher, Mercedes Crecencia. PanAmerican Health Organization; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Daniels, Elaine. National Institutes of Health; Estados UnidosOxford University Press2000-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39231García García, Maria de Lourdes; Valdespino Gómez, Jose Luis; García Sancho, Cecilia; Mayar Maya, Maria Eugenia; Palacios Martínez, Manuel; et al.; Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel; Oxford University Press; International Journal of Epidemiology; 29; 2; 4-2000; 369-3750300-5771CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/ije/29.2.369info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ije/article/29/2/369/758148info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:32Zoai:ri.conicet.gov.ar:11336/39231instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:32.912CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
title Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
spellingShingle Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
García García, Maria de Lourdes
Anergy
Bcg Vaccine
Cd4 Lymphocytes
Delayed-Type Hypersensitivity
Hiv
Tuberculin Test
title_short Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
title_full Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
title_fullStr Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
title_full_unstemmed Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
title_sort Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
dc.creator.none.fl_str_mv García García, Maria de Lourdes
Valdespino Gómez, Jose Luis
García Sancho, Cecilia
Mayar Maya, Maria Eugenia
Palacios Martínez, Manuel
Balandrano Campos, Susana
Escobar Gutiérrez, Alejandro
Peruga, Armando
Weissenbacher, Mercedes Crecencia
Daniels, Elaine
author García García, Maria de Lourdes
author_facet García García, Maria de Lourdes
Valdespino Gómez, Jose Luis
García Sancho, Cecilia
Mayar Maya, Maria Eugenia
Palacios Martínez, Manuel
Balandrano Campos, Susana
Escobar Gutiérrez, Alejandro
Peruga, Armando
Weissenbacher, Mercedes Crecencia
Daniels, Elaine
author_role author
author2 Valdespino Gómez, Jose Luis
García Sancho, Cecilia
Mayar Maya, Maria Eugenia
Palacios Martínez, Manuel
Balandrano Campos, Susana
Escobar Gutiérrez, Alejandro
Peruga, Armando
Weissenbacher, Mercedes Crecencia
Daniels, Elaine
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anergy
Bcg Vaccine
Cd4 Lymphocytes
Delayed-Type Hypersensitivity
Hiv
Tuberculin Test
topic Anergy
Bcg Vaccine
Cd4 Lymphocytes
Delayed-Type Hypersensitivity
Hiv
Tuberculin Test
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background. This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+ lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected individuals in a tuberculosis endemic and high Bacillus Calmette-Guerin (BCG) coverage environment. Methods. Clients of four Mexico City HIV detection centres were screened for HIV-1 anti-bodies (ELISA or haemagglutination, Western Blot); reactivity to PPD (Mantoux PPD, 5TU RT-23), Candida (1:1000, 0.1 ml), and tetanus toxoid (10Lf, 0.1 ml); and CD4+ T cells. Active tuberculosis was excluded. Informed consent was obtained. Results. From 5130 clients 1168 subjects were enrolled; of these 801 (68.6%) were HIV positive. Reactivity to PPD among HIV-positive subjects was found in 174 (22%), 261 (32.6%), and 296 (37%), at PPD cutoff levels of ≥10 mm, ≥5 mm, and ≥2 mm as compared to 224 (61%) of 367 HIV-negative individuals' reactors to PPD (≥10 mm) (P<0.001). After exclusion of anergic individuals using two cutoff levels for cutaneous allergens (≤2 mm and ≤5 mm), PPD reactivity between HIV-infected and uninfected individuals continued to be significantly different. Only HIV-infected individuals with CD4+ T cells ≥500 cells/mm3 had similar reactivity to PPD as HIV-uninfected individuals. Variables associated with PPD reactivity were CD4+ T cell counts, BCG scar, HIV infection and age. Conclusions. PPD reactivity was useful to diagnose tuberculosis infection only among HIV-infected individuals with CD4+ counts ≥500 cells/mm3. Among individuals with lower counts, lowering cutoff levels or using anergy panel did not permit comparable reactivity as that observed among HIV-uninfected individuals.
Fil: García García, Maria de Lourdes. Instituto de Salud Pública; México
Fil: Valdespino Gómez, Jose Luis. Instituto de Salud Pública; México
Fil: García Sancho, Cecilia. Instituto de Salud Pública; México
Fil: Mayar Maya, Maria Eugenia. Instituto de Salud Pública; México
Fil: Palacios Martínez, Manuel. Instituto de Salud Pública; México
Fil: Balandrano Campos, Susana. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; México
Fil: Escobar Gutiérrez, Alejandro. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; México
Fil: Peruga, Armando. PanAmerican Health Organization; Estados Unidos
Fil: Weissenbacher, Mercedes Crecencia. PanAmerican Health Organization; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Daniels, Elaine. National Institutes of Health; Estados Unidos
description Background. This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+ lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected individuals in a tuberculosis endemic and high Bacillus Calmette-Guerin (BCG) coverage environment. Methods. Clients of four Mexico City HIV detection centres were screened for HIV-1 anti-bodies (ELISA or haemagglutination, Western Blot); reactivity to PPD (Mantoux PPD, 5TU RT-23), Candida (1:1000, 0.1 ml), and tetanus toxoid (10Lf, 0.1 ml); and CD4+ T cells. Active tuberculosis was excluded. Informed consent was obtained. Results. From 5130 clients 1168 subjects were enrolled; of these 801 (68.6%) were HIV positive. Reactivity to PPD among HIV-positive subjects was found in 174 (22%), 261 (32.6%), and 296 (37%), at PPD cutoff levels of ≥10 mm, ≥5 mm, and ≥2 mm as compared to 224 (61%) of 367 HIV-negative individuals' reactors to PPD (≥10 mm) (P<0.001). After exclusion of anergic individuals using two cutoff levels for cutaneous allergens (≤2 mm and ≤5 mm), PPD reactivity between HIV-infected and uninfected individuals continued to be significantly different. Only HIV-infected individuals with CD4+ T cells ≥500 cells/mm3 had similar reactivity to PPD as HIV-uninfected individuals. Variables associated with PPD reactivity were CD4+ T cell counts, BCG scar, HIV infection and age. Conclusions. PPD reactivity was useful to diagnose tuberculosis infection only among HIV-infected individuals with CD4+ counts ≥500 cells/mm3. Among individuals with lower counts, lowering cutoff levels or using anergy panel did not permit comparable reactivity as that observed among HIV-uninfected individuals.
publishDate 2000
dc.date.none.fl_str_mv 2000-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39231
García García, Maria de Lourdes; Valdespino Gómez, Jose Luis; García Sancho, Cecilia; Mayar Maya, Maria Eugenia; Palacios Martínez, Manuel; et al.; Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel; Oxford University Press; International Journal of Epidemiology; 29; 2; 4-2000; 369-375
0300-5771
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39231
identifier_str_mv García García, Maria de Lourdes; Valdespino Gómez, Jose Luis; García Sancho, Cecilia; Mayar Maya, Maria Eugenia; Palacios Martínez, Manuel; et al.; Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel; Oxford University Press; International Journal of Epidemiology; 29; 2; 4-2000; 369-375
0300-5771
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/ije/29.2.369
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ije/article/29/2/369/758148
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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