Coating induced corrosion of coronary stents - A comparative study with clinical consequences
- Autores
- Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; Rintoul, Ignacio
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Gustavo Duffó. Comisión Nacional de Energía Atómica; Argentina
Fil: Vetcher, David. Bioimagen; Argentina
Fil: Moles, Victor. Unidad de Intervenciones Cardiovasculares; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina - Materia
-
ALLERGY
BIOCOMPATIBILITY
BIOMATERIAL
CORROSION
IMPLANT
STAINLESS STEEL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/106932
Ver los metadatos del registro completo
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Coating induced corrosion of coronary stents - A comparative study with clinical consequencesNavarro, LucilaGustavo DuffóVetcher, DavidMoles, VictorLuna, Julio AlbertoRintoul, IgnacioALLERGYBIOCOMPATIBILITYBIOMATERIALCORROSIONIMPLANTSTAINLESS STEELhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests.Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Gustavo Duffó. Comisión Nacional de Energía Atómica; ArgentinaFil: Vetcher, David. Bioimagen; ArgentinaFil: Moles, Victor. Unidad de Intervenciones Cardiovasculares; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaPharma Project Group2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106932Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; et al.; Coating induced corrosion of coronary stents - A comparative study with clinical consequences; Pharma Project Group; Trends in Medicine; 6; 1-2020; 220-2261594-2848CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15761/TiM.1000220info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:02:15Zoai:ri.conicet.gov.ar:11336/106932instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:02:15.437CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
title |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
spellingShingle |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences Navarro, Lucila ALLERGY BIOCOMPATIBILITY BIOMATERIAL CORROSION IMPLANT STAINLESS STEEL |
title_short |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
title_full |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
title_fullStr |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
title_full_unstemmed |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
title_sort |
Coating induced corrosion of coronary stents - A comparative study with clinical consequences |
dc.creator.none.fl_str_mv |
Navarro, Lucila Gustavo Duffó Vetcher, David Moles, Victor Luna, Julio Alberto Rintoul, Ignacio |
author |
Navarro, Lucila |
author_facet |
Navarro, Lucila Gustavo Duffó Vetcher, David Moles, Victor Luna, Julio Alberto Rintoul, Ignacio |
author_role |
author |
author2 |
Gustavo Duffó Vetcher, David Moles, Victor Luna, Julio Alberto Rintoul, Ignacio |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
ALLERGY BIOCOMPATIBILITY BIOMATERIAL CORROSION IMPLANT STAINLESS STEEL |
topic |
ALLERGY BIOCOMPATIBILITY BIOMATERIAL CORROSION IMPLANT STAINLESS STEEL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.6 https://purl.org/becyt/ford/2 https://purl.org/becyt/ford/2.9 https://purl.org/becyt/ford/2 https://purl.org/becyt/ford/2.5 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests. Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Gustavo Duffó. Comisión Nacional de Energía Atómica; Argentina Fil: Vetcher, David. Bioimagen; Argentina Fil: Moles, Victor. Unidad de Intervenciones Cardiovasculares; Argentina Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina |
description |
The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/106932 Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; et al.; Coating induced corrosion of coronary stents - A comparative study with clinical consequences; Pharma Project Group; Trends in Medicine; 6; 1-2020; 220-226 1594-2848 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/106932 |
identifier_str_mv |
Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; et al.; Coating induced corrosion of coronary stents - A comparative study with clinical consequences; Pharma Project Group; Trends in Medicine; 6; 1-2020; 220-226 1594-2848 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.15761/TiM.1000220 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pharma Project Group |
publisher.none.fl_str_mv |
Pharma Project Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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