Coating induced corrosion of coronary stents - A comparative study with clinical consequences

Autores
Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; Rintoul, Ignacio
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Gustavo Duffó. Comisión Nacional de Energía Atómica; Argentina
Fil: Vetcher, David. Bioimagen; Argentina
Fil: Moles, Victor. Unidad de Intervenciones Cardiovasculares; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
ALLERGY
BIOCOMPATIBILITY
BIOMATERIAL
CORROSION
IMPLANT
STAINLESS STEEL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/106932
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/106932
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Coating induced corrosion of coronary stents - A comparative study with clinical consequencesNavarro, LucilaGustavo DuffóVetcher, DavidMoles, VictorLuna, Julio AlbertoRintoul, IgnacioALLERGYBIOCOMPATIBILITYBIOMATERIALCORROSIONIMPLANTSTAINLESS STEELhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests.Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Gustavo Duffó. Comisión Nacional de Energía Atómica; ArgentinaFil: Vetcher, David. Bioimagen; ArgentinaFil: Moles, Victor. Unidad de Intervenciones Cardiovasculares; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaPharma Project Group2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106932Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; et al.; Coating induced corrosion of coronary stents - A comparative study with clinical consequences; Pharma Project Group; Trends in Medicine; 6; 1-2020; 220-2261594-2848CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15761/TiM.1000220info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:02:15Zoai:ri.conicet.gov.ar:11336/106932instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:02:15.437CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Coating induced corrosion of coronary stents - A comparative study with clinical consequences
title Coating induced corrosion of coronary stents - A comparative study with clinical consequences
spellingShingle Coating induced corrosion of coronary stents - A comparative study with clinical consequences
Navarro, Lucila
ALLERGY
BIOCOMPATIBILITY
BIOMATERIAL
CORROSION
IMPLANT
STAINLESS STEEL
title_short Coating induced corrosion of coronary stents - A comparative study with clinical consequences
title_full Coating induced corrosion of coronary stents - A comparative study with clinical consequences
title_fullStr Coating induced corrosion of coronary stents - A comparative study with clinical consequences
title_full_unstemmed Coating induced corrosion of coronary stents - A comparative study with clinical consequences
title_sort Coating induced corrosion of coronary stents - A comparative study with clinical consequences
dc.creator.none.fl_str_mv Navarro, Lucila
Gustavo Duffó
Vetcher, David
Moles, Victor
Luna, Julio Alberto
Rintoul, Ignacio
author Navarro, Lucila
author_facet Navarro, Lucila
Gustavo Duffó
Vetcher, David
Moles, Victor
Luna, Julio Alberto
Rintoul, Ignacio
author_role author
author2 Gustavo Duffó
Vetcher, David
Moles, Victor
Luna, Julio Alberto
Rintoul, Ignacio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ALLERGY
BIOCOMPATIBILITY
BIOMATERIAL
CORROSION
IMPLANT
STAINLESS STEEL
topic ALLERGY
BIOCOMPATIBILITY
BIOMATERIAL
CORROSION
IMPLANT
STAINLESS STEEL
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Gustavo Duffó. Comisión Nacional de Energía Atómica; Argentina
Fil: Vetcher, David. Bioimagen; Argentina
Fil: Moles, Victor. Unidad de Intervenciones Cardiovasculares; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description The clinical failsof gold (Au) and carbon (C) coated 316LSS stents have been barelyinvestigated. A comprehensive understanding of these fails maycontribute to the improvement of protocols for the development ofbetter materials and surfaces. This work elucidates the reasons ofthe clinical fails of Au and C coated 316LSS stents, demonstratesthe physical-chemical processes that leaded to these fails, reviewsthe mistaken line of thought that pushed these technologies to themost advanced clinical stages and proposes complementary techniquesto the FDA guidances for the early non-clinical engineering tests. Auand C coated 316LSS, bare-metal 316LSS and Co-Cr stents were studiedusing potentiodynamic scans according to FDA guidance protocols,image analysis and bulk elemental composition. The statisticalclinical outcome of the stents was found to correlate with the ionsrelease patterns eluted from their corresponding metallic substrates.In all cases ions release were consequence of post-passive corrosionprocesses such as pitting corrosion of 316LSS and bulk graindissolution of Co-Cr alloy. Surprisingly, the stents outcome did notcorrelate with their corresponding corrosion rates. Clinical fails ofAu and C coated 316LSS stents are explained in terms of their failsto inhibit the ions release from their 316LSS substrates. Materialsand surface improvements must be oriented to inhibit post-passivecorrosion processes of stents substrates. Potentiodynamic scanscomplemented with image analysis are strongly recommended for theevaluation of pre-clinical engineering tests.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/106932
Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; et al.; Coating induced corrosion of coronary stents - A comparative study with clinical consequences; Pharma Project Group; Trends in Medicine; 6; 1-2020; 220-226
1594-2848
CONICET Digital
CONICET
url http://hdl.handle.net/11336/106932
identifier_str_mv Navarro, Lucila; Gustavo Duffó; Vetcher, David; Moles, Victor; Luna, Julio Alberto; et al.; Coating induced corrosion of coronary stents - A comparative study with clinical consequences; Pharma Project Group; Trends in Medicine; 6; 1-2020; 220-226
1594-2848
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15761/TiM.1000220
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pharma Project Group
publisher.none.fl_str_mv Pharma Project Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.229304

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