Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep

Autores
Ahn, Jinsoo; Wu, Huiguang; Suh, Yeunsu; Carranza Martin, Ana Cristina; Relling, Alejandro Enrique; Shin, Sangsu; Lee, Sang Suk; Lee, Kichoon
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lipolysis is a catabolic reaction that is mediated by adipose triglyceride lipase (ATGL) and its inhibitor such as G0/G1 switch gene 2 (G0S2) protein during the first step of hydrolysis. The hydrophobic domain of G0S2 protein interacts and binds to the patatin-like domain in ATGL. Although conservation of the hydrophobic domain has been reported across species, sheep G0S2 amino acids and its hydrophobic domain have not been sequenced and studied. In this study, the hydrophobic region of G0S2 which plays an important role in inhibition of ATGL-mediated lipolysis was highly conserved as shown in other species. Phylogenetic analysis revealed that ruminant G0S2 proteins showed greater homologies within the ruminant species compared to other mammalian species. Moreover, adipose-specific expression of G0S2 for sheep was observed. Together with an abundant expression of ATGL protein in adipose tissue of sheep, G0S2 protein may play a critical role in inhibiting ATGL-mediated triacylglycerol (TAG) hydrolysis in the adipose tissue.
Fil: Ahn, Jinsoo. Ohio University; Estados Unidos
Fil: Wu, Huiguang. Ohio University; Estados Unidos. Inner Mongolia University for Nationalities; China
Fil: Suh, Yeunsu. Ohio University; Estados Unidos
Fil: Carranza Martin, Ana Cristina. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Relling, Alejandro Enrique. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Shin, Sangsu. Kyungpook National University; Corea del Sur
Fil: Lee, Sang Suk. Ohio University; Estados Unidos. Sunchon National University; Corea del Sur
Fil: Lee, Kichoon. Ohio University; Estados Unidos
Materia
Sheep
G0s2
Atgl
Adipose Tissue
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48104
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheepAhn, JinsooWu, HuiguangSuh, YeunsuCarranza Martin, Ana CristinaRelling, Alejandro EnriqueShin, SangsuLee, Sang SukLee, KichoonSheepG0s2AtglAdipose Tissuehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Lipolysis is a catabolic reaction that is mediated by adipose triglyceride lipase (ATGL) and its inhibitor such as G0/G1 switch gene 2 (G0S2) protein during the first step of hydrolysis. The hydrophobic domain of G0S2 protein interacts and binds to the patatin-like domain in ATGL. Although conservation of the hydrophobic domain has been reported across species, sheep G0S2 amino acids and its hydrophobic domain have not been sequenced and studied. In this study, the hydrophobic region of G0S2 which plays an important role in inhibition of ATGL-mediated lipolysis was highly conserved as shown in other species. Phylogenetic analysis revealed that ruminant G0S2 proteins showed greater homologies within the ruminant species compared to other mammalian species. Moreover, adipose-specific expression of G0S2 for sheep was observed. Together with an abundant expression of ATGL protein in adipose tissue of sheep, G0S2 protein may play a critical role in inhibiting ATGL-mediated triacylglycerol (TAG) hydrolysis in the adipose tissue.Fil: Ahn, Jinsoo. Ohio University; Estados UnidosFil: Wu, Huiguang. Ohio University; Estados Unidos. Inner Mongolia University for Nationalities; ChinaFil: Suh, Yeunsu. Ohio University; Estados UnidosFil: Carranza Martin, Ana Cristina. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Relling, Alejandro Enrique. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Shin, Sangsu. Kyungpook National University; Corea del SurFil: Lee, Sang Suk. Ohio University; Estados Unidos. Sunchon National University; Corea del SurFil: Lee, Kichoon. Ohio University; Estados UnidosElsevier Science2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48104Ahn, Jinsoo; Wu, Huiguang; Suh, Yeunsu; Carranza Martin, Ana Cristina; Relling, Alejandro Enrique; et al.; Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep; Elsevier Science; Journal of Small Ruminant Research; 153; 8-2017; 1-40921-4488CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.smallrumres.2017.05.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0921448817301207info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:39:10Zoai:ri.conicet.gov.ar:11336/48104instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:39:10.623CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
title Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
spellingShingle Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
Ahn, Jinsoo
Sheep
G0s2
Atgl
Adipose Tissue
title_short Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
title_full Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
title_fullStr Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
title_full_unstemmed Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
title_sort Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep
dc.creator.none.fl_str_mv Ahn, Jinsoo
Wu, Huiguang
Suh, Yeunsu
Carranza Martin, Ana Cristina
Relling, Alejandro Enrique
Shin, Sangsu
Lee, Sang Suk
Lee, Kichoon
author Ahn, Jinsoo
author_facet Ahn, Jinsoo
Wu, Huiguang
Suh, Yeunsu
Carranza Martin, Ana Cristina
Relling, Alejandro Enrique
Shin, Sangsu
Lee, Sang Suk
Lee, Kichoon
author_role author
author2 Wu, Huiguang
Suh, Yeunsu
Carranza Martin, Ana Cristina
Relling, Alejandro Enrique
Shin, Sangsu
Lee, Sang Suk
Lee, Kichoon
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sheep
G0s2
Atgl
Adipose Tissue
topic Sheep
G0s2
Atgl
Adipose Tissue
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Lipolysis is a catabolic reaction that is mediated by adipose triglyceride lipase (ATGL) and its inhibitor such as G0/G1 switch gene 2 (G0S2) protein during the first step of hydrolysis. The hydrophobic domain of G0S2 protein interacts and binds to the patatin-like domain in ATGL. Although conservation of the hydrophobic domain has been reported across species, sheep G0S2 amino acids and its hydrophobic domain have not been sequenced and studied. In this study, the hydrophobic region of G0S2 which plays an important role in inhibition of ATGL-mediated lipolysis was highly conserved as shown in other species. Phylogenetic analysis revealed that ruminant G0S2 proteins showed greater homologies within the ruminant species compared to other mammalian species. Moreover, adipose-specific expression of G0S2 for sheep was observed. Together with an abundant expression of ATGL protein in adipose tissue of sheep, G0S2 protein may play a critical role in inhibiting ATGL-mediated triacylglycerol (TAG) hydrolysis in the adipose tissue.
Fil: Ahn, Jinsoo. Ohio University; Estados Unidos
Fil: Wu, Huiguang. Ohio University; Estados Unidos. Inner Mongolia University for Nationalities; China
Fil: Suh, Yeunsu. Ohio University; Estados Unidos
Fil: Carranza Martin, Ana Cristina. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Relling, Alejandro Enrique. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Shin, Sangsu. Kyungpook National University; Corea del Sur
Fil: Lee, Sang Suk. Ohio University; Estados Unidos. Sunchon National University; Corea del Sur
Fil: Lee, Kichoon. Ohio University; Estados Unidos
description Lipolysis is a catabolic reaction that is mediated by adipose triglyceride lipase (ATGL) and its inhibitor such as G0/G1 switch gene 2 (G0S2) protein during the first step of hydrolysis. The hydrophobic domain of G0S2 protein interacts and binds to the patatin-like domain in ATGL. Although conservation of the hydrophobic domain has been reported across species, sheep G0S2 amino acids and its hydrophobic domain have not been sequenced and studied. In this study, the hydrophobic region of G0S2 which plays an important role in inhibition of ATGL-mediated lipolysis was highly conserved as shown in other species. Phylogenetic analysis revealed that ruminant G0S2 proteins showed greater homologies within the ruminant species compared to other mammalian species. Moreover, adipose-specific expression of G0S2 for sheep was observed. Together with an abundant expression of ATGL protein in adipose tissue of sheep, G0S2 protein may play a critical role in inhibiting ATGL-mediated triacylglycerol (TAG) hydrolysis in the adipose tissue.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48104
Ahn, Jinsoo; Wu, Huiguang; Suh, Yeunsu; Carranza Martin, Ana Cristina; Relling, Alejandro Enrique; et al.; Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep; Elsevier Science; Journal of Small Ruminant Research; 153; 8-2017; 1-4
0921-4488
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48104
identifier_str_mv Ahn, Jinsoo; Wu, Huiguang; Suh, Yeunsu; Carranza Martin, Ana Cristina; Relling, Alejandro Enrique; et al.; Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep; Elsevier Science; Journal of Small Ruminant Research; 153; 8-2017; 1-4
0921-4488
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.smallrumres.2017.05.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0921448817301207
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082875086077952
score 13.22299

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