Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
- Autores
- Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; Isaac, Vera L. B.; Cicarelli, Regina M. B.; López, Silvia Noelí
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
Fil: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina - Materia
-
Chalcone
Flavokawin B
Polygonaceae
Polygonum Ferrugineum
Trans-Splicing
Trypanosoma Brucei
Trypanosoma Cruzi - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/53390
Ver los metadatos del registro completo
| id |
CONICETDig_d39a545ae900108509b6417f731fa992 |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/53390 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum WeddRodrigues, Danilo F.Maniscalco, David A.Silva, Flavia A. J.Chiari, Bruna G.Castelli, Maria VictoriaIsaac, Vera L. B.Cicarelli, Regina M. B.López, Silvia NoelíChalconeFlavokawin BPolygonaceaePolygonum FerrugineumTrans-SplicingTrypanosoma BruceiTrypanosoma Cruzihttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.Fil: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaGeorg Thieme Verlag Kg2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53390Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; et al.; Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd; Georg Thieme Verlag Kg; Planta Medica; 83; 3-4; 2-2017; 239-2440032-0943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.com/DOI/DOI?10.1055/s-0042-112031info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0042-112031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:27:38Zoai:ri.conicet.gov.ar:11336/53390instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:27:39.149CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| title |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| spellingShingle |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd Rodrigues, Danilo F. Chalcone Flavokawin B Polygonaceae Polygonum Ferrugineum Trans-Splicing Trypanosoma Brucei Trypanosoma Cruzi |
| title_short |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| title_full |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| title_fullStr |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| title_full_unstemmed |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| title_sort |
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd |
| dc.creator.none.fl_str_mv |
Rodrigues, Danilo F. Maniscalco, David A. Silva, Flavia A. J. Chiari, Bruna G. Castelli, Maria Victoria Isaac, Vera L. B. Cicarelli, Regina M. B. López, Silvia Noelí |
| author |
Rodrigues, Danilo F. |
| author_facet |
Rodrigues, Danilo F. Maniscalco, David A. Silva, Flavia A. J. Chiari, Bruna G. Castelli, Maria Victoria Isaac, Vera L. B. Cicarelli, Regina M. B. López, Silvia Noelí |
| author_role |
author |
| author2 |
Maniscalco, David A. Silva, Flavia A. J. Chiari, Bruna G. Castelli, Maria Victoria Isaac, Vera L. B. Cicarelli, Regina M. B. López, Silvia Noelí |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Chalcone Flavokawin B Polygonaceae Polygonum Ferrugineum Trans-Splicing Trypanosoma Brucei Trypanosoma Cruzi |
| topic |
Chalcone Flavokawin B Polygonaceae Polygonum Ferrugineum Trans-Splicing Trypanosoma Brucei Trypanosoma Cruzi |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease. Fil: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina Fil: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina Fil: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina |
| description |
The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-02 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/53390 Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; et al.; Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd; Georg Thieme Verlag Kg; Planta Medica; 83; 3-4; 2-2017; 239-244 0032-0943 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/53390 |
| identifier_str_mv |
Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; et al.; Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd; Georg Thieme Verlag Kg; Planta Medica; 83; 3-4; 2-2017; 239-244 0032-0943 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.com/DOI/DOI?10.1055/s-0042-112031 info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0042-112031 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
| publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1846781847282909184 |
| score |
12.982451 |