Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd

Autores
Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; Isaac, Vera L. B.; Cicarelli, Regina M. B.; López, Silvia Noelí
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
Fil: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Materia
Chalcone
Flavokawin B
Polygonaceae
Polygonum Ferrugineum
Trans-Splicing
Trypanosoma Brucei
Trypanosoma Cruzi
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53390

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oai_identifier_str oai:ri.conicet.gov.ar:11336/53390
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network_name_str CONICET Digital (CONICET)
spelling Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum WeddRodrigues, Danilo F.Maniscalco, David A.Silva, Flavia A. J.Chiari, Bruna G.Castelli, Maria VictoriaIsaac, Vera L. B.Cicarelli, Regina M. B.López, Silvia NoelíChalconeFlavokawin BPolygonaceaePolygonum FerrugineumTrans-SplicingTrypanosoma BruceiTrypanosoma Cruzihttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.Fil: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaGeorg Thieme Verlag Kg2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53390Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; et al.; Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd; Georg Thieme Verlag Kg; Planta Medica; 83; 3-4; 2-2017; 239-2440032-0943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.com/DOI/DOI?10.1055/s-0042-112031info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0042-112031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:20Zoai:ri.conicet.gov.ar:11336/53390instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:21.104CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
title Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
spellingShingle Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
Rodrigues, Danilo F.
Chalcone
Flavokawin B
Polygonaceae
Polygonum Ferrugineum
Trans-Splicing
Trypanosoma Brucei
Trypanosoma Cruzi
title_short Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
title_full Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
title_fullStr Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
title_full_unstemmed Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
title_sort Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
dc.creator.none.fl_str_mv Rodrigues, Danilo F.
Maniscalco, David A.
Silva, Flavia A. J.
Chiari, Bruna G.
Castelli, Maria Victoria
Isaac, Vera L. B.
Cicarelli, Regina M. B.
López, Silvia Noelí
author Rodrigues, Danilo F.
author_facet Rodrigues, Danilo F.
Maniscalco, David A.
Silva, Flavia A. J.
Chiari, Bruna G.
Castelli, Maria Victoria
Isaac, Vera L. B.
Cicarelli, Regina M. B.
López, Silvia Noelí
author_role author
author2 Maniscalco, David A.
Silva, Flavia A. J.
Chiari, Bruna G.
Castelli, Maria Victoria
Isaac, Vera L. B.
Cicarelli, Regina M. B.
López, Silvia Noelí
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chalcone
Flavokawin B
Polygonaceae
Polygonum Ferrugineum
Trans-Splicing
Trypanosoma Brucei
Trypanosoma Cruzi
topic Chalcone
Flavokawin B
Polygonaceae
Polygonum Ferrugineum
Trans-Splicing
Trypanosoma Brucei
Trypanosoma Cruzi
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
Fil: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
description The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53390
Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; et al.; Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd; Georg Thieme Verlag Kg; Planta Medica; 83; 3-4; 2-2017; 239-244
0032-0943
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53390
identifier_str_mv Rodrigues, Danilo F.; Maniscalco, David A.; Silva, Flavia A. J.; Chiari, Bruna G.; Castelli, Maria Victoria; et al.; Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd; Georg Thieme Verlag Kg; Planta Medica; 83; 3-4; 2-2017; 239-244
0032-0943
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.com/DOI/DOI?10.1055/s-0042-112031
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0042-112031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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