Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
- Autores
- Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; Gonzalez Montaner, Pablo; Ambroggi, Marta; Ritacco, Gloria Viviana; Van soolingen, Dick
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB.
Fil: Abbate, Eduardo. Universidad de Buenos Aires; Argentina
Fil: Vescovo, Marisa. Universidad de Buenos Aires; Argentina
Fil: Natiello, Marcela. Universidad de Buenos Aires; Argentina
Fil: Cufré, Mónica. Universidad de Buenos Aires; Argentina
Fil: García, Ana. Universidad de Buenos Aires; Argentina
Fil: Gonzalez Montaner, Pablo. Universidad de Buenos Aires; Argentina
Fil: Ambroggi, Marta. Universidad de Buenos Aires; Argentina
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Van soolingen, Dick. National Institute Of Public Health And The Environment; Países Bajos - Materia
-
ADVERSE EFFECTS
FLUOROQUINOLONES
PHENOTHIAZINES
TOXICITY
TREATMENT OUTCOME - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/194839
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/194839 |
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3498 |
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CONICET Digital (CONICET) |
spelling |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazineAbbate, EduardoVescovo, MarisaNatiello, MarcelaCufré, MónicaGarcía, AnaGonzalez Montaner, PabloAmbroggi, MartaRitacco, Gloria VivianaVan soolingen, DickADVERSE EFFECTSFLUOROQUINOLONESPHENOTHIAZINESTOXICITYTREATMENT OUTCOMEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB.Fil: Abbate, Eduardo. Universidad de Buenos Aires; ArgentinaFil: Vescovo, Marisa. Universidad de Buenos Aires; ArgentinaFil: Natiello, Marcela. Universidad de Buenos Aires; ArgentinaFil: Cufré, Mónica. Universidad de Buenos Aires; ArgentinaFil: García, Ana. Universidad de Buenos Aires; ArgentinaFil: Gonzalez Montaner, Pablo. Universidad de Buenos Aires; ArgentinaFil: Ambroggi, Marta. Universidad de Buenos Aires; ArgentinaFil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Van soolingen, Dick. National Institute Of Public Health And The Environment; Países BajosOxford University Press2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194839Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; et al.; Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 2; 2-2012; 473-4770305-7453CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jac.oxfordjournals.org/content/67/2/473.longinfo:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkr500info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:16Zoai:ri.conicet.gov.ar:11336/194839instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:17.085CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
title |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
spellingShingle |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine Abbate, Eduardo ADVERSE EFFECTS FLUOROQUINOLONES PHENOTHIAZINES TOXICITY TREATMENT OUTCOME |
title_short |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
title_full |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
title_fullStr |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
title_full_unstemmed |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
title_sort |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine |
dc.creator.none.fl_str_mv |
Abbate, Eduardo Vescovo, Marisa Natiello, Marcela Cufré, Mónica García, Ana Gonzalez Montaner, Pablo Ambroggi, Marta Ritacco, Gloria Viviana Van soolingen, Dick |
author |
Abbate, Eduardo |
author_facet |
Abbate, Eduardo Vescovo, Marisa Natiello, Marcela Cufré, Mónica García, Ana Gonzalez Montaner, Pablo Ambroggi, Marta Ritacco, Gloria Viviana Van soolingen, Dick |
author_role |
author |
author2 |
Vescovo, Marisa Natiello, Marcela Cufré, Mónica García, Ana Gonzalez Montaner, Pablo Ambroggi, Marta Ritacco, Gloria Viviana Van soolingen, Dick |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
ADVERSE EFFECTS FLUOROQUINOLONES PHENOTHIAZINES TOXICITY TREATMENT OUTCOME |
topic |
ADVERSE EFFECTS FLUOROQUINOLONES PHENOTHIAZINES TOXICITY TREATMENT OUTCOME |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB. Fil: Abbate, Eduardo. Universidad de Buenos Aires; Argentina Fil: Vescovo, Marisa. Universidad de Buenos Aires; Argentina Fil: Natiello, Marcela. Universidad de Buenos Aires; Argentina Fil: Cufré, Mónica. Universidad de Buenos Aires; Argentina Fil: García, Ana. Universidad de Buenos Aires; Argentina Fil: Gonzalez Montaner, Pablo. Universidad de Buenos Aires; Argentina Fil: Ambroggi, Marta. Universidad de Buenos Aires; Argentina Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Van soolingen, Dick. National Institute Of Public Health And The Environment; Países Bajos |
description |
Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/194839 Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; et al.; Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 2; 2-2012; 473-477 0305-7453 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/194839 |
identifier_str_mv |
Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; et al.; Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 2; 2-2012; 473-477 0305-7453 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://jac.oxfordjournals.org/content/67/2/473.long info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkr500 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614322782732288 |
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13.070432 |