Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine

Autores
Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; Gonzalez Montaner, Pablo; Ambroggi, Marta; Ritacco, Gloria Viviana; Van soolingen, Dick
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB.
Fil: Abbate, Eduardo. Universidad de Buenos Aires; Argentina
Fil: Vescovo, Marisa. Universidad de Buenos Aires; Argentina
Fil: Natiello, Marcela. Universidad de Buenos Aires; Argentina
Fil: Cufré, Mónica. Universidad de Buenos Aires; Argentina
Fil: García, Ana. Universidad de Buenos Aires; Argentina
Fil: Gonzalez Montaner, Pablo. Universidad de Buenos Aires; Argentina
Fil: Ambroggi, Marta. Universidad de Buenos Aires; Argentina
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Van soolingen, Dick. National Institute Of Public Health And The Environment; Países Bajos
Materia
ADVERSE EFFECTS
FLUOROQUINOLONES
PHENOTHIAZINES
TOXICITY
TREATMENT OUTCOME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194839
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/194839
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazineAbbate, EduardoVescovo, MarisaNatiello, MarcelaCufré, MónicaGarcía, AnaGonzalez Montaner, PabloAmbroggi, MartaRitacco, Gloria VivianaVan soolingen, DickADVERSE EFFECTSFLUOROQUINOLONESPHENOTHIAZINESTOXICITYTREATMENT OUTCOMEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB.Fil: Abbate, Eduardo. Universidad de Buenos Aires; ArgentinaFil: Vescovo, Marisa. Universidad de Buenos Aires; ArgentinaFil: Natiello, Marcela. Universidad de Buenos Aires; ArgentinaFil: Cufré, Mónica. Universidad de Buenos Aires; ArgentinaFil: García, Ana. Universidad de Buenos Aires; ArgentinaFil: Gonzalez Montaner, Pablo. Universidad de Buenos Aires; ArgentinaFil: Ambroggi, Marta. Universidad de Buenos Aires; ArgentinaFil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Van soolingen, Dick. National Institute Of Public Health And The Environment; Países BajosOxford University Press2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194839Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; et al.; Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 2; 2-2012; 473-4770305-7453CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jac.oxfordjournals.org/content/67/2/473.longinfo:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkr500info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:03:43Zoai:ri.conicet.gov.ar:11336/194839instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:03:43.225CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
title Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
spellingShingle Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
Abbate, Eduardo
ADVERSE EFFECTS
FLUOROQUINOLONES
PHENOTHIAZINES
TOXICITY
TREATMENT OUTCOME
title_short Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
title_full Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
title_fullStr Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
title_full_unstemmed Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
title_sort Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine
dc.creator.none.fl_str_mv Abbate, Eduardo
Vescovo, Marisa
Natiello, Marcela
Cufré, Mónica
García, Ana
Gonzalez Montaner, Pablo
Ambroggi, Marta
Ritacco, Gloria Viviana
Van soolingen, Dick
author Abbate, Eduardo
author_facet Abbate, Eduardo
Vescovo, Marisa
Natiello, Marcela
Cufré, Mónica
García, Ana
Gonzalez Montaner, Pablo
Ambroggi, Marta
Ritacco, Gloria Viviana
Van soolingen, Dick
author_role author
author2 Vescovo, Marisa
Natiello, Marcela
Cufré, Mónica
García, Ana
Gonzalez Montaner, Pablo
Ambroggi, Marta
Ritacco, Gloria Viviana
Van soolingen, Dick
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADVERSE EFFECTS
FLUOROQUINOLONES
PHENOTHIAZINES
TOXICITY
TREATMENT OUTCOME
topic ADVERSE EFFECTS
FLUOROQUINOLONES
PHENOTHIAZINES
TOXICITY
TREATMENT OUTCOME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB.
Fil: Abbate, Eduardo. Universidad de Buenos Aires; Argentina
Fil: Vescovo, Marisa. Universidad de Buenos Aires; Argentina
Fil: Natiello, Marcela. Universidad de Buenos Aires; Argentina
Fil: Cufré, Mónica. Universidad de Buenos Aires; Argentina
Fil: García, Ana. Universidad de Buenos Aires; Argentina
Fil: Gonzalez Montaner, Pablo. Universidad de Buenos Aires; Argentina
Fil: Ambroggi, Marta. Universidad de Buenos Aires; Argentina
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Van soolingen, Dick. National Institute Of Public Health And The Environment; Países Bajos
description Objectives: Current drug choices to treat extensively drug-resistant (XDR) tuberculosis (TB) are scarce; therefore, information on the safety, tolerability and efficacy of alternative regimens is of utmost importance. The aim of this study was to describe the management, drug adverse effects and outcome of alternative combined treatment in a series of XDR-TB patients. Patients and methods: A retrospective study was performed on 17 non-AIDS, pulmonary adult patients with XDR-TB admitted to a referral treatment centre for infectious diseases in Buenos Aires from 2002 through 2008. Drug susceptibility testing was performed under regular proficiency testing and confirmed at the national TB reference laboratory. Results: Linezolid was included in the drug regimens of all patients; moxifloxacin and/or thioridazine were included in the regimens of 14 patients. Clinically tractable drug adverse effects were observed in nine patients, the most frequent being haematological disorders and neurotoxicity. In two patients, thioridazine was discontinued. Negative culture conversion was achieved in 15 patients, 11 completed treatment meeting cure criteria, 4 are still on follow-up with good evolution, 1 defaulted treatment and 1 was lost to follow-up. Conclusions: The combination of linezolid, moxifloxacin and thioridazine is recommended for compassionate use in specialized centres with expertise in the management of XDR-TB.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194839
Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; et al.; Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 2; 2-2012; 473-477
0305-7453
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194839
identifier_str_mv Abbate, Eduardo; Vescovo, Marisa; Natiello, Marcela; Cufré, Mónica; García, Ana; et al.; Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina by a combination of linezolid, moxifloxacin and thioridazine; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 2; 2-2012; 473-477
0305-7453
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jac.oxfordjournals.org/content/67/2/473.long
info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkr500
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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