Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin

Autores
Strazza, Ariel Ramiro; Montagna, Daniela Romina; Aixala, Mónica; Meiss, Roberto P.; Chiarella, Paula; Ruggiero, Raul Alejandro
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host inhibits the growthofsecondary tumor implants. The relevance of CR to mechanisms of metastases control has been highlightedby numerous observations showing that the removal of human and murine tumors may be followed by anabrupt increase in metastatic growth. This body of evidence suggests that, upon certain circumstances, aprimary tumor would exert a controlling action on its metastases that can be considered as naturalsecondary tumor implants spontaneously developed during the primary tumor growth.In this article werevised both former and recent evidence accounting for this fact in both experimental and clinical settingsand discussed the situations in which tumor removal would be or would not be recommended. In addition,we analyzed the different mechanisms historically proposed to explain CR especially focusing on the lastinvestigations of our laboratory concerning the importance of tyrosine isomers as mediators of thephenomenon of CR and on their capacity to inhibit established metastases of both murine and human origin.Our investigations aimed to elucidate the molecular basis of the phenomenon of CR might stimulatethedesign of new strategies aimed to limit the development of metastases,an issue of critical importance forpatients afflicted by malignant diseases.
Fil: Strazza, Ariel Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Montagna, Daniela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Aixala, Mónica. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Metastases,
Concomitant Tumor Resistance,
Murine And Human Tumors,
Tyrosine Isomers.
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64915
Acceder
id CONICETDig_d263dec0da0664ed7ef6abc54343c383
oai_identifier_str oai:ri.conicet.gov.ar:11336/64915
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human originStrazza, Ariel RamiroMontagna, Daniela RominaAixala, MónicaMeiss, Roberto P.Chiarella, PaulaRuggiero, Raul AlejandroMetastases,Concomitant Tumor Resistance,Murine And Human Tumors,Tyrosine Isomers.https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host inhibits the growthofsecondary tumor implants. The relevance of CR to mechanisms of metastases control has been highlightedby numerous observations showing that the removal of human and murine tumors may be followed by anabrupt increase in metastatic growth. This body of evidence suggests that, upon certain circumstances, aprimary tumor would exert a controlling action on its metastases that can be considered as naturalsecondary tumor implants spontaneously developed during the primary tumor growth.In this article werevised both former and recent evidence accounting for this fact in both experimental and clinical settingsand discussed the situations in which tumor removal would be or would not be recommended. In addition,we analyzed the different mechanisms historically proposed to explain CR especially focusing on the lastinvestigations of our laboratory concerning the importance of tyrosine isomers as mediators of thephenomenon of CR and on their capacity to inhibit established metastases of both murine and human origin.Our investigations aimed to elucidate the molecular basis of the phenomenon of CR might stimulatethedesign of new strategies aimed to limit the development of metastases,an issue of critical importance forpatients afflicted by malignant diseases.Fil: Strazza, Ariel Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Montagna, Daniela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Aixala, Mónica. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaGlobal Advanced Research Journals2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64915Strazza, Ariel Ramiro; Montagna, Daniela Romina; Aixala, Mónica; Meiss, Roberto P.; Chiarella, Paula; et al.; Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin; Global Advanced Research Journals; Journal of Medicine and Medical Sciences; 6; 12; 12-2017; 341-3512315-5159CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://garj.org/garjmms/12/2017/6/12/revisiting-the-phenomenon-of-concomitant-tumor-resistance-and-its-impact-on-established-metastases-of-murine-and-human-origininfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:49Zoai:ri.conicet.gov.ar:11336/64915instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:49.701CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
title Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
spellingShingle Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
Strazza, Ariel Ramiro
Metastases,
Concomitant Tumor Resistance,
Murine And Human Tumors,
Tyrosine Isomers.
title_short Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
title_full Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
title_fullStr Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
title_full_unstemmed Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
title_sort Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin
dc.creator.none.fl_str_mv Strazza, Ariel Ramiro
Montagna, Daniela Romina
Aixala, Mónica
Meiss, Roberto P.
Chiarella, Paula
Ruggiero, Raul Alejandro
author Strazza, Ariel Ramiro
author_facet Strazza, Ariel Ramiro
Montagna, Daniela Romina
Aixala, Mónica
Meiss, Roberto P.
Chiarella, Paula
Ruggiero, Raul Alejandro
author_role author
author2 Montagna, Daniela Romina
Aixala, Mónica
Meiss, Roberto P.
Chiarella, Paula
Ruggiero, Raul Alejandro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Metastases,
Concomitant Tumor Resistance,
Murine And Human Tumors,
Tyrosine Isomers.
topic Metastases,
Concomitant Tumor Resistance,
Murine And Human Tumors,
Tyrosine Isomers.
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host inhibits the growthofsecondary tumor implants. The relevance of CR to mechanisms of metastases control has been highlightedby numerous observations showing that the removal of human and murine tumors may be followed by anabrupt increase in metastatic growth. This body of evidence suggests that, upon certain circumstances, aprimary tumor would exert a controlling action on its metastases that can be considered as naturalsecondary tumor implants spontaneously developed during the primary tumor growth.In this article werevised both former and recent evidence accounting for this fact in both experimental and clinical settingsand discussed the situations in which tumor removal would be or would not be recommended. In addition,we analyzed the different mechanisms historically proposed to explain CR especially focusing on the lastinvestigations of our laboratory concerning the importance of tyrosine isomers as mediators of thephenomenon of CR and on their capacity to inhibit established metastases of both murine and human origin.Our investigations aimed to elucidate the molecular basis of the phenomenon of CR might stimulatethedesign of new strategies aimed to limit the development of metastases,an issue of critical importance forpatients afflicted by malignant diseases.
Fil: Strazza, Ariel Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Montagna, Daniela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Aixala, Mónica. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host inhibits the growthofsecondary tumor implants. The relevance of CR to mechanisms of metastases control has been highlightedby numerous observations showing that the removal of human and murine tumors may be followed by anabrupt increase in metastatic growth. This body of evidence suggests that, upon certain circumstances, aprimary tumor would exert a controlling action on its metastases that can be considered as naturalsecondary tumor implants spontaneously developed during the primary tumor growth.In this article werevised both former and recent evidence accounting for this fact in both experimental and clinical settingsand discussed the situations in which tumor removal would be or would not be recommended. In addition,we analyzed the different mechanisms historically proposed to explain CR especially focusing on the lastinvestigations of our laboratory concerning the importance of tyrosine isomers as mediators of thephenomenon of CR and on their capacity to inhibit established metastases of both murine and human origin.Our investigations aimed to elucidate the molecular basis of the phenomenon of CR might stimulatethedesign of new strategies aimed to limit the development of metastases,an issue of critical importance forpatients afflicted by malignant diseases.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64915
Strazza, Ariel Ramiro; Montagna, Daniela Romina; Aixala, Mónica; Meiss, Roberto P.; Chiarella, Paula; et al.; Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin; Global Advanced Research Journals; Journal of Medicine and Medical Sciences; 6; 12; 12-2017; 341-351
2315-5159
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64915
identifier_str_mv Strazza, Ariel Ramiro; Montagna, Daniela Romina; Aixala, Mónica; Meiss, Roberto P.; Chiarella, Paula; et al.; Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin; Global Advanced Research Journals; Journal of Medicine and Medical Sciences; 6; 12; 12-2017; 341-351
2315-5159
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://garj.org/garjmms/12/2017/6/12/revisiting-the-phenomenon-of-concomitant-tumor-resistance-and-its-impact-on-established-metastases-of-murine-and-human-origin
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Global Advanced Research Journals
publisher.none.fl_str_mv Global Advanced Research Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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