Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
- Autores
- Kolliker Frers, Rodolfo Alberto; Otero-losada, Matilde Estela; Kobiec, Tamara; Udovin, Lucas; Aon Bertolino, Maria Laura; Herrera, María Inés; Capani, Francisco
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations. Axonal damage associated with the inflammatory process causes neurofilaments, the major neuron structural proteins, to be released into the extracellular space, reaching the cerebrospinal fluid (CSF) and the peripheral blood. Methodological advances in neurofilaments’ serological detection and imaging technology, along with many clinical and therapeutic studies in the last years, have deepened our understanding of MS immunopathogenesis. This review examines the use of light chain neurofilaments (NFLs) as peripheral MS biomarkers in light of the current clinical and therapeutic evidence, MS immunopathology, and technological advances in diagnostic tools. It aims to highlight NFL multidimensional value as a reliable MS biomarker with a diagnostic-prognostic profile while improving our comprehension of inflammatory neurodegenerative processes, mainly RRMS, the most frequent clinical presentation of MS.
Fil: Kolliker Frers, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kobiec, Tamara. Universidad Abierta Interamericana; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Udovin, Lucas. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aon Bertolino, Maria Laura. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herrera, María Inés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina - Materia
-
AXONAL DAMAGE
DIAGNOSIS
MONITORING
MULTIPLE SCLEROSIS
NEUROFILAMENTS (NFS)
SERUM DETECTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/223635
Ver los metadatos del registro completo
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Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosisKolliker Frers, Rodolfo AlbertoOtero-losada, Matilde EstelaKobiec, TamaraUdovin, LucasAon Bertolino, Maria LauraHerrera, María InésCapani, FranciscoAXONAL DAMAGEDIAGNOSISMONITORINGMULTIPLE SCLEROSISNEUROFILAMENTS (NFS)SERUM DETECTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations. Axonal damage associated with the inflammatory process causes neurofilaments, the major neuron structural proteins, to be released into the extracellular space, reaching the cerebrospinal fluid (CSF) and the peripheral blood. Methodological advances in neurofilaments’ serological detection and imaging technology, along with many clinical and therapeutic studies in the last years, have deepened our understanding of MS immunopathogenesis. This review examines the use of light chain neurofilaments (NFLs) as peripheral MS biomarkers in light of the current clinical and therapeutic evidence, MS immunopathology, and technological advances in diagnostic tools. It aims to highlight NFL multidimensional value as a reliable MS biomarker with a diagnostic-prognostic profile while improving our comprehension of inflammatory neurodegenerative processes, mainly RRMS, the most frequent clinical presentation of MS.Fil: Kolliker Frers, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kobiec, Tamara. Universidad Abierta Interamericana; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Udovin, Lucas. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aon Bertolino, Maria Laura. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herrera, María Inés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capani, Francisco. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Argentina "John F. Kennedy"; ArgentinaFrontiers Media2022-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/223635Kolliker Frers, Rodolfo Alberto; Otero-losada, Matilde Estela; Kobiec, Tamara; Udovin, Lucas; Aon Bertolino, Maria Laura; et al.; Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis; Frontiers Media; Frontiers in Immunology; 13; 7-2022; 1-191664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.912005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:10Zoai:ri.conicet.gov.ar:11336/223635instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:11.034CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
title |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
spellingShingle |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis Kolliker Frers, Rodolfo Alberto AXONAL DAMAGE DIAGNOSIS MONITORING MULTIPLE SCLEROSIS NEUROFILAMENTS (NFS) SERUM DETECTION |
title_short |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
title_full |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
title_fullStr |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
title_full_unstemmed |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
title_sort |
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis |
dc.creator.none.fl_str_mv |
Kolliker Frers, Rodolfo Alberto Otero-losada, Matilde Estela Kobiec, Tamara Udovin, Lucas Aon Bertolino, Maria Laura Herrera, María Inés Capani, Francisco |
author |
Kolliker Frers, Rodolfo Alberto |
author_facet |
Kolliker Frers, Rodolfo Alberto Otero-losada, Matilde Estela Kobiec, Tamara Udovin, Lucas Aon Bertolino, Maria Laura Herrera, María Inés Capani, Francisco |
author_role |
author |
author2 |
Otero-losada, Matilde Estela Kobiec, Tamara Udovin, Lucas Aon Bertolino, Maria Laura Herrera, María Inés Capani, Francisco |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
AXONAL DAMAGE DIAGNOSIS MONITORING MULTIPLE SCLEROSIS NEUROFILAMENTS (NFS) SERUM DETECTION |
topic |
AXONAL DAMAGE DIAGNOSIS MONITORING MULTIPLE SCLEROSIS NEUROFILAMENTS (NFS) SERUM DETECTION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations. Axonal damage associated with the inflammatory process causes neurofilaments, the major neuron structural proteins, to be released into the extracellular space, reaching the cerebrospinal fluid (CSF) and the peripheral blood. Methodological advances in neurofilaments’ serological detection and imaging technology, along with many clinical and therapeutic studies in the last years, have deepened our understanding of MS immunopathogenesis. This review examines the use of light chain neurofilaments (NFLs) as peripheral MS biomarkers in light of the current clinical and therapeutic evidence, MS immunopathology, and technological advances in diagnostic tools. It aims to highlight NFL multidimensional value as a reliable MS biomarker with a diagnostic-prognostic profile while improving our comprehension of inflammatory neurodegenerative processes, mainly RRMS, the most frequent clinical presentation of MS. Fil: Kolliker Frers, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Kobiec, Tamara. Universidad Abierta Interamericana; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Udovin, Lucas. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aon Bertolino, Maria Laura. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Herrera, María Inés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capani, Francisco. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina |
description |
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations. Axonal damage associated with the inflammatory process causes neurofilaments, the major neuron structural proteins, to be released into the extracellular space, reaching the cerebrospinal fluid (CSF) and the peripheral blood. Methodological advances in neurofilaments’ serological detection and imaging technology, along with many clinical and therapeutic studies in the last years, have deepened our understanding of MS immunopathogenesis. This review examines the use of light chain neurofilaments (NFLs) as peripheral MS biomarkers in light of the current clinical and therapeutic evidence, MS immunopathology, and technological advances in diagnostic tools. It aims to highlight NFL multidimensional value as a reliable MS biomarker with a diagnostic-prognostic profile while improving our comprehension of inflammatory neurodegenerative processes, mainly RRMS, the most frequent clinical presentation of MS. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/223635 Kolliker Frers, Rodolfo Alberto; Otero-losada, Matilde Estela; Kobiec, Tamara; Udovin, Lucas; Aon Bertolino, Maria Laura; et al.; Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis; Frontiers Media; Frontiers in Immunology; 13; 7-2022; 1-19 1664-3224 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/223635 |
identifier_str_mv |
Kolliker Frers, Rodolfo Alberto; Otero-losada, Matilde Estela; Kobiec, Tamara; Udovin, Lucas; Aon Bertolino, Maria Laura; et al.; Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis; Frontiers Media; Frontiers in Immunology; 13; 7-2022; 1-19 1664-3224 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.912005 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613359204302848 |
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13.070432 |