Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions

Autores
Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis Guillermo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd.
Fil: Uriu, Koichiro. Max Planck Institute For The Physics Of Complex Systems; Alemania. Max Planck Institute Of Molecular Cell Biology And Genetics; Alemania
Fil: Ares, Saúl. Max Planck Institute For The Physics Of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute Of Molecular Cell Biology And Genetics; Alemania
Fil: Morelli, Luis Guillermo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Materia
Cellular Mobility,
Intercellular Interaction
Recovery of Signaling
Synchronization
Coupled Mobile Oscillators
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55630
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactionsUriu, KoichiroAres, SaúlOates, Andrew C.Morelli, Luis GuillermoCellular Mobility,Intercellular InteractionRecovery of SignalingSynchronizationCoupled Mobile Oscillatorshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd.Fil: Uriu, Koichiro. Max Planck Institute For The Physics Of Complex Systems; Alemania. Max Planck Institute Of Molecular Cell Biology And Genetics; AlemaniaFil: Ares, Saúl. Max Planck Institute For The Physics Of Complex Systems; AlemaniaFil: Oates, Andrew C.. Max Planck Institute Of Molecular Cell Biology And Genetics; AlemaniaFil: Morelli, Luis Guillermo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaIOP Publishing2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55630Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis Guillermo; Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions; IOP Publishing; Physical Biology; 9; 3; 4-2012; 1-111478-3967CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://iopscience.iop.org/1478-3975/9/3/036006info:eu-repo/semantics/altIdentifier/doi/10.1088/1478-3975/9/3/036006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:31Zoai:ri.conicet.gov.ar:11336/55630instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:31.675CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
spellingShingle Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
Uriu, Koichiro
Cellular Mobility,
Intercellular Interaction
Recovery of Signaling
Synchronization
Coupled Mobile Oscillators
title_short Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_full Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_fullStr Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_full_unstemmed Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_sort Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
dc.creator.none.fl_str_mv Uriu, Koichiro
Ares, Saúl
Oates, Andrew C.
Morelli, Luis Guillermo
author Uriu, Koichiro
author_facet Uriu, Koichiro
Ares, Saúl
Oates, Andrew C.
Morelli, Luis Guillermo
author_role author
author2 Ares, Saúl
Oates, Andrew C.
Morelli, Luis Guillermo
author2_role author
author
author
dc.subject.none.fl_str_mv Cellular Mobility,
Intercellular Interaction
Recovery of Signaling
Synchronization
Coupled Mobile Oscillators
topic Cellular Mobility,
Intercellular Interaction
Recovery of Signaling
Synchronization
Coupled Mobile Oscillators
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd.
Fil: Uriu, Koichiro. Max Planck Institute For The Physics Of Complex Systems; Alemania. Max Planck Institute Of Molecular Cell Biology And Genetics; Alemania
Fil: Ares, Saúl. Max Planck Institute For The Physics Of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute Of Molecular Cell Biology And Genetics; Alemania
Fil: Morelli, Luis Guillermo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
description Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55630
Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis Guillermo; Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions; IOP Publishing; Physical Biology; 9; 3; 4-2012; 1-11
1478-3967
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55630
identifier_str_mv Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis Guillermo; Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions; IOP Publishing; Physical Biology; 9; 3; 4-2012; 1-11
1478-3967
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://iopscience.iop.org/1478-3975/9/3/036006
info:eu-repo/semantics/altIdentifier/doi/10.1088/1478-3975/9/3/036006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOP Publishing
publisher.none.fl_str_mv IOP Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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