Enamel formation genes influence enamel microhardness before and after cariogenic challenge

Autores: Shimizu, Takehiko; Ho, Bao; Deeley, Kathleen; Briseño Ruiz, Jessica; Faraco, Italo M.; Schupack, Brett I.; Brancher, João A.; Pecharki, Giovana D.; Küchler, Erika C.; Tannure, Patricia N.; Lips, Andrea; Vieira, Thays C. S.; Patir, Asli; Yildirim, Mine; Poletta, Fernando Adrián; Mereb, Juan C.; Resick, Judith M.; Brandon, Carla A.; Orioli, Ieda Maria; Castilla, Eduardo Enrique; Marazita, Mary L.; Seymen, Figen; Costa, Marcelo C.; Granjeiro, José M.; Trevilatto, Paula C.; Vieira, Alexandre R.
Año de publicación: 2012
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity.
Fil: Shimizu, Takehiko. Nihon University of Dentistry; Japón
Fil: Ho, Bao. University of Pittsburgh; Estados Unidos
Fil: Deeley, Kathleen. University of Pittsburgh; Estados Unidos
Fil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados Unidos
Fil: Faraco, Italo M.. University of Pittsburgh; Estados Unidos
Fil: Schupack, Brett I.. University of Pittsburgh; Estados Unidos
Fil: Brancher, João A.. Pontificia Universidad Catolica de Parana; Brasil
Fil: Pecharki, Giovana D.. Pontificia Universidad Catolica de Parana; Brasil
Fil: Küchler, Erika C.. Universidade Federal Fluminense; Brasil
Fil: Tannure, Patricia N.. Veiga de Almeida University; Brasil
Fil: Lips, Andrea. Universidade Federal do Rio de Janeiro; Brasil
Fil: Vieira, Thays C. S.. Universidade Federal Fluminense; Brasil
Fil: Patir, Asli. Istanbul Medipol University; Turquía
Fil: Yildirim, Mine. Istanbul University; Turquía
Fil: Poletta, Fernando Adrián. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mereb, Juan C.. Gobierno de la Provincia de Rio Negro. Hospital de Area El Bolson; Argentina
Fil: Resick, Judith M.. University of Pittsburgh; Estados Unidos
Fil: Brandon, Carla A.. University of Pittsburgh; Estados Unidos
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil
Fil: Castilla, Eduardo Enrique. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos
Fil: Seymen, Figen. Istanbul University; Turquía
Fil: Costa, Marcelo C.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Granjeiro, José M.. Universidade Federal Fluminense; Brasil
Fil: Trevilatto, Paula C.. Pontificia Universidad Catolica de Parana; Brasil
Fil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos
Materia: Cariogenic
Enamel
microhardness
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/260939

Acceder

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network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Enamel formation genes influence enamel microhardness before and after cariogenic challengeShimizu, TakehikoHo, BaoDeeley, KathleenBriseño Ruiz, JessicaFaraco, Italo M.Schupack, Brett I.Brancher, João A.Pecharki, Giovana D.Küchler, Erika C.Tannure, Patricia N.Lips, AndreaVieira, Thays C. S.Patir, AsliYildirim, MinePoletta, Fernando AdriánMereb, Juan C.Resick, Judith M.Brandon, Carla A.Orioli, Ieda MariaCastilla, Eduardo EnriqueMarazita, Mary L.Seymen, FigenCosta, Marcelo C.Granjeiro, José M.Trevilatto, Paula C.Vieira, Alexandre R.CariogenicEnamelmicrohardnesshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity.Fil: Shimizu, Takehiko. Nihon University of Dentistry; JapónFil: Ho, Bao. University of Pittsburgh; Estados UnidosFil: Deeley, Kathleen. University of Pittsburgh; Estados UnidosFil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados UnidosFil: Faraco, Italo M.. University of Pittsburgh; Estados UnidosFil: Schupack, Brett I.. University of Pittsburgh; Estados UnidosFil: Brancher, João A.. Pontificia Universidad Catolica de Parana; BrasilFil: Pecharki, Giovana D.. Pontificia Universidad Catolica de Parana; BrasilFil: Küchler, Erika C.. Universidade Federal Fluminense; BrasilFil: Tannure, Patricia N.. Veiga de Almeida University; BrasilFil: Lips, Andrea. Universidade Federal do Rio de Janeiro; BrasilFil: Vieira, Thays C. S.. Universidade Federal Fluminense; BrasilFil: Patir, Asli. Istanbul Medipol University; TurquíaFil: Yildirim, Mine. Istanbul University; TurquíaFil: Poletta, Fernando Adrián. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mereb, Juan C.. Gobierno de la Provincia de Rio Negro. Hospital de Area El Bolson; ArgentinaFil: Resick, Judith M.. University of Pittsburgh; Estados UnidosFil: Brandon, Carla A.. University of Pittsburgh; Estados UnidosFil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; BrasilFil: Castilla, Eduardo Enrique. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marazita, Mary L.. University of Pittsburgh; Estados UnidosFil: Seymen, Figen. Istanbul University; TurquíaFil: Costa, Marcelo C.. Universidade Federal do Rio de Janeiro; BrasilFil: Granjeiro, José M.. Universidade Federal Fluminense; BrasilFil: Trevilatto, Paula C.. Pontificia Universidad Catolica de Parana; BrasilFil: Vieira, Alexandre R.. University of Pittsburgh; Estados UnidosPublic Library of Science2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260939Shimizu, Takehiko; Ho, Bao; Deeley, Kathleen; Briseño Ruiz, Jessica; Faraco, Italo M.; et al.; Enamel formation genes influence enamel microhardness before and after cariogenic challenge; Public Library of Science; Plos One; 7; 45022; 9-2012; 1-91932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0045022info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:30Zoai:ri.conicet.gov.ar:11336/260939instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:30.45CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
title	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
spellingShingle	Enamel formation genes influence enamel microhardness before and after cariogenic challenge Shimizu, Takehiko Cariogenic Enamel microhardness
title_short	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
title_full	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
title_fullStr	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
title_full_unstemmed	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
title_sort	Enamel formation genes influence enamel microhardness before and after cariogenic challenge
dc.creator.none.fl_str_mv	Shimizu, Takehiko Ho, Bao Deeley, Kathleen Briseño Ruiz, Jessica Faraco, Italo M. Schupack, Brett I. Brancher, João A. Pecharki, Giovana D. Küchler, Erika C. Tannure, Patricia N. Lips, Andrea Vieira, Thays C. S. Patir, Asli Yildirim, Mine Poletta, Fernando Adrián Mereb, Juan C. Resick, Judith M. Brandon, Carla A. Orioli, Ieda Maria Castilla, Eduardo Enrique Marazita, Mary L. Seymen, Figen Costa, Marcelo C. Granjeiro, José M. Trevilatto, Paula C. Vieira, Alexandre R.
author	Shimizu, Takehiko
author_facet	Shimizu, Takehiko Ho, Bao Deeley, Kathleen Briseño Ruiz, Jessica Faraco, Italo M. Schupack, Brett I. Brancher, João A. Pecharki, Giovana D. Küchler, Erika C. Tannure, Patricia N. Lips, Andrea Vieira, Thays C. S. Patir, Asli Yildirim, Mine Poletta, Fernando Adrián Mereb, Juan C. Resick, Judith M. Brandon, Carla A. Orioli, Ieda Maria Castilla, Eduardo Enrique Marazita, Mary L. Seymen, Figen Costa, Marcelo C. Granjeiro, José M. Trevilatto, Paula C. Vieira, Alexandre R.
author_role	author
author2	Ho, Bao Deeley, Kathleen Briseño Ruiz, Jessica Faraco, Italo M. Schupack, Brett I. Brancher, João A. Pecharki, Giovana D. Küchler, Erika C. Tannure, Patricia N. Lips, Andrea Vieira, Thays C. S. Patir, Asli Yildirim, Mine Poletta, Fernando Adrián Mereb, Juan C. Resick, Judith M. Brandon, Carla A. Orioli, Ieda Maria Castilla, Eduardo Enrique Marazita, Mary L. Seymen, Figen Costa, Marcelo C. Granjeiro, José M. Trevilatto, Paula C. Vieira, Alexandre R.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Cariogenic Enamel microhardness
topic	Cariogenic Enamel microhardness
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity. Fil: Shimizu, Takehiko. Nihon University of Dentistry; Japón Fil: Ho, Bao. University of Pittsburgh; Estados Unidos Fil: Deeley, Kathleen. University of Pittsburgh; Estados Unidos Fil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados Unidos Fil: Faraco, Italo M.. University of Pittsburgh; Estados Unidos Fil: Schupack, Brett I.. University of Pittsburgh; Estados Unidos Fil: Brancher, João A.. Pontificia Universidad Catolica de Parana; Brasil Fil: Pecharki, Giovana D.. Pontificia Universidad Catolica de Parana; Brasil Fil: Küchler, Erika C.. Universidade Federal Fluminense; Brasil Fil: Tannure, Patricia N.. Veiga de Almeida University; Brasil Fil: Lips, Andrea. Universidade Federal do Rio de Janeiro; Brasil Fil: Vieira, Thays C. S.. Universidade Federal Fluminense; Brasil Fil: Patir, Asli. Istanbul Medipol University; Turquía Fil: Yildirim, Mine. Istanbul University; Turquía Fil: Poletta, Fernando Adrián. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mereb, Juan C.. Gobierno de la Provincia de Rio Negro. Hospital de Area El Bolson; Argentina Fil: Resick, Judith M.. University of Pittsburgh; Estados Unidos Fil: Brandon, Carla A.. University of Pittsburgh; Estados Unidos Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil Fil: Castilla, Eduardo Enrique. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos Fil: Seymen, Figen. Istanbul University; Turquía Fil: Costa, Marcelo C.. Universidade Federal do Rio de Janeiro; Brasil Fil: Granjeiro, José M.. Universidade Federal Fluminense; Brasil Fil: Trevilatto, Paula C.. Pontificia Universidad Catolica de Parana; Brasil Fil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos
description	There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity.
publishDate	2012
dc.date.none.fl_str_mv	2012-09
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/260939 Shimizu, Takehiko; Ho, Bao; Deeley, Kathleen; Briseño Ruiz, Jessica; Faraco, Italo M.; et al.; Enamel formation genes influence enamel microhardness before and after cariogenic challenge; Public Library of Science; Plos One; 7; 45022; 9-2012; 1-9 1932-6203 CONICET Digital CONICET
url	http://hdl.handle.net/11336/260939
identifier_str_mv	Shimizu, Takehiko; Ho, Bao; Deeley, Kathleen; Briseño Ruiz, Jessica; Faraco, Italo M.; et al.; Enamel formation genes influence enamel microhardness before and after cariogenic challenge; Public Library of Science; Plos One; 7; 45022; 9-2012; 1-9 1932-6203 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0045022 info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045022
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dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Enamel formation genes influence enamel microhardness before and after cariogenic challenge

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