Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension

Autores
Presa, Jessica Lorena; Saravia, Flavia Eugenia; Bagi, Zsolt; Filosa, Jessica A.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating evidence for cellular elements of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling. We discuss how alterations in the cellular mechanisms governing NVU homeostasis can lead to pathological changes in which vascular endothelial and smooth muscle cell, pericyte and astrocyte function may play a key role. Because hypertension is a modifiable risk factor for stroke and accelerated cognitive decline in aging, we focus on hypertension-associated changes on cerebral arteriole function and structure, and the molecular mechanisms through which these may contribute to cognitive decline. We gather recent emerging evidence concerning cognitive loss in hypertension and the link with vascular dementia and Alzheimer’s disease. Collectively, we summarize how vascular dysfunction, chronic hypoperfusion, oxidative stress, and inflammatory processes can uncouple communication at the NVU impairing cerebral perfusion and contributing to neurodegeneration.
Fil: Presa, Jessica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Bagi, Zsolt. Augusta University; Estados Unidos
Fil: Filosa, Jessica A.. Augusta University; Estados Unidos
Materia
ASTROCYTE
COGNTIVE DECLINE
ISCHEMIA
NEUROVASCULAR
PULSATILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/203890
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/203890
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertensionPresa, Jessica LorenaSaravia, Flavia EugeniaBagi, ZsoltFilosa, Jessica A.ASTROCYTECOGNTIVE DECLINEISCHEMIANEUROVASCULARPULSATILITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating evidence for cellular elements of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling. We discuss how alterations in the cellular mechanisms governing NVU homeostasis can lead to pathological changes in which vascular endothelial and smooth muscle cell, pericyte and astrocyte function may play a key role. Because hypertension is a modifiable risk factor for stroke and accelerated cognitive decline in aging, we focus on hypertension-associated changes on cerebral arteriole function and structure, and the molecular mechanisms through which these may contribute to cognitive decline. We gather recent emerging evidence concerning cognitive loss in hypertension and the link with vascular dementia and Alzheimer’s disease. Collectively, we summarize how vascular dysfunction, chronic hypoperfusion, oxidative stress, and inflammatory processes can uncouple communication at the NVU impairing cerebral perfusion and contributing to neurodegeneration.Fil: Presa, Jessica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Bagi, Zsolt. Augusta University; Estados UnidosFil: Filosa, Jessica A.. Augusta University; Estados UnidosFrontiers Media2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/203890Presa, Jessica Lorena; Saravia, Flavia Eugenia; Bagi, Zsolt; Filosa, Jessica A.; Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension; Frontiers Media; Frontiers in Physiology; 11; 2020; 1-191664-042XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2020.584135info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:34Zoai:ri.conicet.gov.ar:11336/203890instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:34.812CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
title Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
spellingShingle Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
Presa, Jessica Lorena
ASTROCYTE
COGNTIVE DECLINE
ISCHEMIA
NEUROVASCULAR
PULSATILITY
title_short Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
title_full Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
title_fullStr Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
title_full_unstemmed Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
title_sort Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
dc.creator.none.fl_str_mv Presa, Jessica Lorena
Saravia, Flavia Eugenia
Bagi, Zsolt
Filosa, Jessica A.
author Presa, Jessica Lorena
author_facet Presa, Jessica Lorena
Saravia, Flavia Eugenia
Bagi, Zsolt
Filosa, Jessica A.
author_role author
author2 Saravia, Flavia Eugenia
Bagi, Zsolt
Filosa, Jessica A.
author2_role author
author
author
dc.subject.none.fl_str_mv ASTROCYTE
COGNTIVE DECLINE
ISCHEMIA
NEUROVASCULAR
PULSATILITY
topic ASTROCYTE
COGNTIVE DECLINE
ISCHEMIA
NEUROVASCULAR
PULSATILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating evidence for cellular elements of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling. We discuss how alterations in the cellular mechanisms governing NVU homeostasis can lead to pathological changes in which vascular endothelial and smooth muscle cell, pericyte and astrocyte function may play a key role. Because hypertension is a modifiable risk factor for stroke and accelerated cognitive decline in aging, we focus on hypertension-associated changes on cerebral arteriole function and structure, and the molecular mechanisms through which these may contribute to cognitive decline. We gather recent emerging evidence concerning cognitive loss in hypertension and the link with vascular dementia and Alzheimer’s disease. Collectively, we summarize how vascular dysfunction, chronic hypoperfusion, oxidative stress, and inflammatory processes can uncouple communication at the NVU impairing cerebral perfusion and contributing to neurodegeneration.
Fil: Presa, Jessica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Bagi, Zsolt. Augusta University; Estados Unidos
Fil: Filosa, Jessica A.. Augusta University; Estados Unidos
description Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating evidence for cellular elements of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling. We discuss how alterations in the cellular mechanisms governing NVU homeostasis can lead to pathological changes in which vascular endothelial and smooth muscle cell, pericyte and astrocyte function may play a key role. Because hypertension is a modifiable risk factor for stroke and accelerated cognitive decline in aging, we focus on hypertension-associated changes on cerebral arteriole function and structure, and the molecular mechanisms through which these may contribute to cognitive decline. We gather recent emerging evidence concerning cognitive loss in hypertension and the link with vascular dementia and Alzheimer’s disease. Collectively, we summarize how vascular dysfunction, chronic hypoperfusion, oxidative stress, and inflammatory processes can uncouple communication at the NVU impairing cerebral perfusion and contributing to neurodegeneration.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/203890
Presa, Jessica Lorena; Saravia, Flavia Eugenia; Bagi, Zsolt; Filosa, Jessica A.; Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension; Frontiers Media; Frontiers in Physiology; 11; 2020; 1-19
1664-042X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/203890
identifier_str_mv Presa, Jessica Lorena; Saravia, Flavia Eugenia; Bagi, Zsolt; Filosa, Jessica A.; Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension; Frontiers Media; Frontiers in Physiology; 11; 2020; 1-19
1664-042X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2020.584135
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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