Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis

Autores
Iurisci, Ida; Cumashi, Albana; Sherman, Andrei; Tsvetkov, Yuri E.; Tinari, Nicola; Piccolo, Enza; D'Egidio, Maurizia; Adamo, Vincenzo; Natoli, Clara; Rabinovich, Gabriel Adrián; Iacobelli, Stefano; Nifantiev, Nikolay E.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectins have emerged as critical regulators of tumor progression and metastasis, by modulating different biological events including homotypic cell aggregation, apoptosis, migration, angiogenesis and immune escape. Therefore, galectin inhibitors might represent novel therapeutic agents for cancer. A series of structural analogs of the disaccharide methyl beta-lactosaminide were screened as potential galectin inhibitors by examining their capability to block binding of galectin-1 and/or galectin-3 to LGalS3BP in solid-phase assays. To demonstrate any functional role in vitro, oligosaccharides were characterized by their ability to regulate tumor cell apoptosis and LGalS3BP-induced homotypic cell aggregation.
Fil: Iurisci, Ida. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Cumashi, Albana. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Sherman, Andrei. Russian Academy of Sciences; Rusia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Tsvetkov, Yuri E.. Russian Academy of Sciences; Rusia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Tinari, Nicola. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Piccolo, Enza. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: D'Egidio, Maurizia. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Adamo, Vincenzo. Università degli Studi di Messina; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Natoli, Clara. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Iacobelli, Stefano. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Nifantiev, Nikolay E.. Russian Academy of Sciences; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Materia
Galectin-1
Synthetic Inhibitors
Tumors
Homotypic Cell Adhesion
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24813
Acceder
id CONICETDig_cc68dffc86d0a786e16f4690b42809c3
oai_identifier_str oai:ri.conicet.gov.ar:11336/24813
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosisIurisci, IdaCumashi, AlbanaSherman, AndreiTsvetkov, Yuri E.Tinari, NicolaPiccolo, EnzaD'Egidio, MauriziaAdamo, VincenzoNatoli, ClaraRabinovich, Gabriel AdriánIacobelli, StefanoNifantiev, Nikolay E.Galectin-1Synthetic InhibitorsTumorsHomotypic Cell Adhesionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectins have emerged as critical regulators of tumor progression and metastasis, by modulating different biological events including homotypic cell aggregation, apoptosis, migration, angiogenesis and immune escape. Therefore, galectin inhibitors might represent novel therapeutic agents for cancer. A series of structural analogs of the disaccharide methyl beta-lactosaminide were screened as potential galectin inhibitors by examining their capability to block binding of galectin-1 and/or galectin-3 to LGalS3BP in solid-phase assays. To demonstrate any functional role in vitro, oligosaccharides were characterized by their ability to regulate tumor cell apoptosis and LGalS3BP-induced homotypic cell aggregation.Fil: Iurisci, Ida. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Cumashi, Albana. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Sherman, Andrei. Russian Academy of Sciences; Rusia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Tsvetkov, Yuri E.. Russian Academy of Sciences; Rusia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Tinari, Nicola. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Piccolo, Enza. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: D'Egidio, Maurizia. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Adamo, Vincenzo. Università degli Studi di Messina; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Natoli, Clara. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Iacobelli, Stefano. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaFil: Nifantiev, Nikolay E.. Russian Academy of Sciences; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; ItaliaInt Inst Anticancer Research2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24813Iurisci, Ida; Cumashi, Albana; Sherman, Andrei; Tsvetkov, Yuri E.; Tinari, Nicola; et al.; Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis; Int Inst Anticancer Research; Anticancer Research; 29; 1; 2009; 403-4100250-70051791-7530CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ar.iiarjournals.org/content/29/1/403.longinfo:eu-repo/semantics/altIdentifier/pmid/19331179info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:36:12Zoai:ri.conicet.gov.ar:11336/24813instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:36:12.264CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
title Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
spellingShingle Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
Iurisci, Ida
Galectin-1
Synthetic Inhibitors
Tumors
Homotypic Cell Adhesion
title_short Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
title_full Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
title_fullStr Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
title_full_unstemmed Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
title_sort Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
dc.creator.none.fl_str_mv Iurisci, Ida
Cumashi, Albana
Sherman, Andrei
Tsvetkov, Yuri E.
Tinari, Nicola
Piccolo, Enza
D'Egidio, Maurizia
Adamo, Vincenzo
Natoli, Clara
Rabinovich, Gabriel Adrián
Iacobelli, Stefano
Nifantiev, Nikolay E.
author Iurisci, Ida
author_facet Iurisci, Ida
Cumashi, Albana
Sherman, Andrei
Tsvetkov, Yuri E.
Tinari, Nicola
Piccolo, Enza
D'Egidio, Maurizia
Adamo, Vincenzo
Natoli, Clara
Rabinovich, Gabriel Adrián
Iacobelli, Stefano
Nifantiev, Nikolay E.
author_role author
author2 Cumashi, Albana
Sherman, Andrei
Tsvetkov, Yuri E.
Tinari, Nicola
Piccolo, Enza
D'Egidio, Maurizia
Adamo, Vincenzo
Natoli, Clara
Rabinovich, Gabriel Adrián
Iacobelli, Stefano
Nifantiev, Nikolay E.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Galectin-1
Synthetic Inhibitors
Tumors
Homotypic Cell Adhesion
topic Galectin-1
Synthetic Inhibitors
Tumors
Homotypic Cell Adhesion
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectins have emerged as critical regulators of tumor progression and metastasis, by modulating different biological events including homotypic cell aggregation, apoptosis, migration, angiogenesis and immune escape. Therefore, galectin inhibitors might represent novel therapeutic agents for cancer. A series of structural analogs of the disaccharide methyl beta-lactosaminide were screened as potential galectin inhibitors by examining their capability to block binding of galectin-1 and/or galectin-3 to LGalS3BP in solid-phase assays. To demonstrate any functional role in vitro, oligosaccharides were characterized by their ability to regulate tumor cell apoptosis and LGalS3BP-induced homotypic cell aggregation.
Fil: Iurisci, Ida. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Cumashi, Albana. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Sherman, Andrei. Russian Academy of Sciences; Rusia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Tsvetkov, Yuri E.. Russian Academy of Sciences; Rusia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Tinari, Nicola. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Piccolo, Enza. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: D'Egidio, Maurizia. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Adamo, Vincenzo. Università degli Studi di Messina; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Natoli, Clara. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Iacobelli, Stefano. Fondazione Università G. d’Annunzio; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
Fil: Nifantiev, Nikolay E.. Russian Academy of Sciences; Italia. Consorzio Interuniversitario Nazionale Per la Bio-Oncologia; Italia
description Galectins have emerged as critical regulators of tumor progression and metastasis, by modulating different biological events including homotypic cell aggregation, apoptosis, migration, angiogenesis and immune escape. Therefore, galectin inhibitors might represent novel therapeutic agents for cancer. A series of structural analogs of the disaccharide methyl beta-lactosaminide were screened as potential galectin inhibitors by examining their capability to block binding of galectin-1 and/or galectin-3 to LGalS3BP in solid-phase assays. To demonstrate any functional role in vitro, oligosaccharides were characterized by their ability to regulate tumor cell apoptosis and LGalS3BP-induced homotypic cell aggregation.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24813
Iurisci, Ida; Cumashi, Albana; Sherman, Andrei; Tsvetkov, Yuri E.; Tinari, Nicola; et al.; Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis; Int Inst Anticancer Research; Anticancer Research; 29; 1; 2009; 403-410
0250-7005
1791-7530
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24813
identifier_str_mv Iurisci, Ida; Cumashi, Albana; Sherman, Andrei; Tsvetkov, Yuri E.; Tinari, Nicola; et al.; Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis; Int Inst Anticancer Research; Anticancer Research; 29; 1; 2009; 403-410
0250-7005
1791-7530
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ar.iiarjournals.org/content/29/1/403.long
info:eu-repo/semantics/altIdentifier/pmid/19331179
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Int Inst Anticancer Research
publisher.none.fl_str_mv Int Inst Anticancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082826430054400
score 13.22299

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