Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode

Autores
Rinaldi, Ana Laura; Carballo, Romina Raquel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A non-enzymatic glucose sensor based on a thin layer of nickel immobilized on a gold electrode (EAuNi(OH)2) was used to perform impedimetric determination of glucose. The electrodeposition solution, composed of 0.010 M Ni(NO3)2·6H2O and 1 M of chloride, allows only one active catalyst (NiOOH) to be present on the gold electrode surface after activation with 0.1 M KOH. Electrochemical oxidation of glucose on EAuNi(OH)2 electrode was evaluated by Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) in the concentration range of 0-14.8 mM of analyte. Ip/v1/2 vs scan rate graph shows a typical catalytic behavior by EAuNi(OH)2 toward glucose oxidation. Measurements in the presence of possible interfering species (ascorbic acid, uric acid, dopamine) did not affect the response of the analyte of interest. EIS offers good sensibility and selectivity for the glucose detection by non-enzymatic glucose sensor as an alternative to conventional methods. A single-frequency impedance method is proposed as transduction principle. For that, the parameters of complex impedance (module, phase, real and imaginary impedance) at each frequency were evaluated in function of glucose concentration and in terms of correlation coefficient. These analyses show a better linear response for the module of impedance (|Z|) in the range of 0-2 mM of glucose at 0.1 Hz (R2 = 0.984) with a slope of 484.7 Ω mM-1 of glucose. Finally, EAuNi(OH)2 was successfully applied to the assay of glucose in blood samples.
Fil: Rinaldi, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; Argentina
Fil: Carballo, Romina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; Argentina
Materia
Blood Sample
Electrochemical Impedance Spectroscopy
Glucose
Nickel Gold Electrode
Non-Enzymatic Sensor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38763
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrodeRinaldi, Ana LauraCarballo, Romina RaquelBlood SampleElectrochemical Impedance SpectroscopyGlucoseNickel Gold ElectrodeNon-Enzymatic Sensorhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A non-enzymatic glucose sensor based on a thin layer of nickel immobilized on a gold electrode (EAuNi(OH)2) was used to perform impedimetric determination of glucose. The electrodeposition solution, composed of 0.010 M Ni(NO3)2·6H2O and 1 M of chloride, allows only one active catalyst (NiOOH) to be present on the gold electrode surface after activation with 0.1 M KOH. Electrochemical oxidation of glucose on EAuNi(OH)2 electrode was evaluated by Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) in the concentration range of 0-14.8 mM of analyte. Ip/v1/2 vs scan rate graph shows a typical catalytic behavior by EAuNi(OH)2 toward glucose oxidation. Measurements in the presence of possible interfering species (ascorbic acid, uric acid, dopamine) did not affect the response of the analyte of interest. EIS offers good sensibility and selectivity for the glucose detection by non-enzymatic glucose sensor as an alternative to conventional methods. A single-frequency impedance method is proposed as transduction principle. For that, the parameters of complex impedance (module, phase, real and imaginary impedance) at each frequency were evaluated in function of glucose concentration and in terms of correlation coefficient. These analyses show a better linear response for the module of impedance (|Z|) in the range of 0-2 mM of glucose at 0.1 Hz (R2 = 0.984) with a slope of 484.7 Ω mM-1 of glucose. Finally, EAuNi(OH)2 was successfully applied to the assay of glucose in blood samples.Fil: Rinaldi, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; ArgentinaFil: Carballo, Romina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; ArgentinaElsevier Science Sa2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38763Rinaldi, Ana Laura; Carballo, Romina Raquel; Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode; Elsevier Science Sa; Sensors and Actuators B: Chemical; 228; 6-2016; 43-520925-4005CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.snb.2015.12.101info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S092540051530825Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:23Zoai:ri.conicet.gov.ar:11336/38763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:24.043CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
title Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
spellingShingle Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
Rinaldi, Ana Laura
Blood Sample
Electrochemical Impedance Spectroscopy
Glucose
Nickel Gold Electrode
Non-Enzymatic Sensor
title_short Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
title_full Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
title_fullStr Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
title_full_unstemmed Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
title_sort Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode
dc.creator.none.fl_str_mv Rinaldi, Ana Laura
Carballo, Romina Raquel
author Rinaldi, Ana Laura
author_facet Rinaldi, Ana Laura
Carballo, Romina Raquel
author_role author
author2 Carballo, Romina Raquel
author2_role author
dc.subject.none.fl_str_mv Blood Sample
Electrochemical Impedance Spectroscopy
Glucose
Nickel Gold Electrode
Non-Enzymatic Sensor
topic Blood Sample
Electrochemical Impedance Spectroscopy
Glucose
Nickel Gold Electrode
Non-Enzymatic Sensor
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A non-enzymatic glucose sensor based on a thin layer of nickel immobilized on a gold electrode (EAuNi(OH)2) was used to perform impedimetric determination of glucose. The electrodeposition solution, composed of 0.010 M Ni(NO3)2·6H2O and 1 M of chloride, allows only one active catalyst (NiOOH) to be present on the gold electrode surface after activation with 0.1 M KOH. Electrochemical oxidation of glucose on EAuNi(OH)2 electrode was evaluated by Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) in the concentration range of 0-14.8 mM of analyte. Ip/v1/2 vs scan rate graph shows a typical catalytic behavior by EAuNi(OH)2 toward glucose oxidation. Measurements in the presence of possible interfering species (ascorbic acid, uric acid, dopamine) did not affect the response of the analyte of interest. EIS offers good sensibility and selectivity for the glucose detection by non-enzymatic glucose sensor as an alternative to conventional methods. A single-frequency impedance method is proposed as transduction principle. For that, the parameters of complex impedance (module, phase, real and imaginary impedance) at each frequency were evaluated in function of glucose concentration and in terms of correlation coefficient. These analyses show a better linear response for the module of impedance (|Z|) in the range of 0-2 mM of glucose at 0.1 Hz (R2 = 0.984) with a slope of 484.7 Ω mM-1 of glucose. Finally, EAuNi(OH)2 was successfully applied to the assay of glucose in blood samples.
Fil: Rinaldi, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; Argentina
Fil: Carballo, Romina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; Argentina
description A non-enzymatic glucose sensor based on a thin layer of nickel immobilized on a gold electrode (EAuNi(OH)2) was used to perform impedimetric determination of glucose. The electrodeposition solution, composed of 0.010 M Ni(NO3)2·6H2O and 1 M of chloride, allows only one active catalyst (NiOOH) to be present on the gold electrode surface after activation with 0.1 M KOH. Electrochemical oxidation of glucose on EAuNi(OH)2 electrode was evaluated by Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) in the concentration range of 0-14.8 mM of analyte. Ip/v1/2 vs scan rate graph shows a typical catalytic behavior by EAuNi(OH)2 toward glucose oxidation. Measurements in the presence of possible interfering species (ascorbic acid, uric acid, dopamine) did not affect the response of the analyte of interest. EIS offers good sensibility and selectivity for the glucose detection by non-enzymatic glucose sensor as an alternative to conventional methods. A single-frequency impedance method is proposed as transduction principle. For that, the parameters of complex impedance (module, phase, real and imaginary impedance) at each frequency were evaluated in function of glucose concentration and in terms of correlation coefficient. These analyses show a better linear response for the module of impedance (|Z|) in the range of 0-2 mM of glucose at 0.1 Hz (R2 = 0.984) with a slope of 484.7 Ω mM-1 of glucose. Finally, EAuNi(OH)2 was successfully applied to the assay of glucose in blood samples.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38763
Rinaldi, Ana Laura; Carballo, Romina Raquel; Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode; Elsevier Science Sa; Sensors and Actuators B: Chemical; 228; 6-2016; 43-52
0925-4005
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38763
identifier_str_mv Rinaldi, Ana Laura; Carballo, Romina Raquel; Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode; Elsevier Science Sa; Sensors and Actuators B: Chemical; 228; 6-2016; 43-52
0925-4005
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.snb.2015.12.101
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S092540051530825X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613064118239232
score 13.070432

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