Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory

Autores
Katche, Cynthia Lorena; Dorman, Guido; Slipczuk, Leandro; Cammarota, Martin Pablo; Medina, Jorge Horacio
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.
Fil: Katche, Cynthia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Dorman, Guido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Slipczuk, Leandro. Einstein Medical Center; Estados Unidos
Fil: Cammarota, Martin Pablo. Pontificia Universidade Catolica Do Rio Grande Do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Materia
PROTEIN SYNTHESIS
mRNA SYNTHESIS
MUSCIMOL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17386
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memoryKatche, Cynthia LorenaDorman, GuidoSlipczuk, LeandroCammarota, Martin PabloMedina, Jorge HoracioPROTEIN SYNTHESISmRNA SYNTHESISMUSCIMOLhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.Fil: Katche, Cynthia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Dorman, Guido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Slipczuk, Leandro. Einstein Medical Center; Estados UnidosFil: Cammarota, Martin Pablo. Pontificia Universidade Catolica Do Rio Grande Do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaCold Spring Harbor Lab Press2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17386Katche, Cynthia Lorena; Dorman, Guido; Slipczuk, Leandro; Cammarota, Martin Pablo; Medina, Jorge Horacio; Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory; Cold Spring Harbor Lab Press; Learning & Memory (cold Spring Harbor, N.y.); 20; 4; 5-2013; 170-1731072-05021549-5485enginfo:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/20/4/170.fullinfo:eu-repo/semantics/altIdentifier/doi/10.1101/lm.030080.112info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:37Zoai:ri.conicet.gov.ar:11336/17386instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:37.597CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
spellingShingle Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
Katche, Cynthia Lorena
PROTEIN SYNTHESIS
mRNA SYNTHESIS
MUSCIMOL
title_short Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_full Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_fullStr Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_full_unstemmed Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_sort Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
dc.creator.none.fl_str_mv Katche, Cynthia Lorena
Dorman, Guido
Slipczuk, Leandro
Cammarota, Martin Pablo
Medina, Jorge Horacio
author Katche, Cynthia Lorena
author_facet Katche, Cynthia Lorena
Dorman, Guido
Slipczuk, Leandro
Cammarota, Martin Pablo
Medina, Jorge Horacio
author_role author
author2 Dorman, Guido
Slipczuk, Leandro
Cammarota, Martin Pablo
Medina, Jorge Horacio
author2_role author
author
author
author
dc.subject.none.fl_str_mv PROTEIN SYNTHESIS
mRNA SYNTHESIS
MUSCIMOL
topic PROTEIN SYNTHESIS
mRNA SYNTHESIS
MUSCIMOL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.
Fil: Katche, Cynthia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Dorman, Guido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Slipczuk, Leandro. Einstein Medical Center; Estados Unidos
Fil: Cammarota, Martin Pablo. Pontificia Universidade Catolica Do Rio Grande Do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
description Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17386
Katche, Cynthia Lorena; Dorman, Guido; Slipczuk, Leandro; Cammarota, Martin Pablo; Medina, Jorge Horacio; Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory; Cold Spring Harbor Lab Press; Learning & Memory (cold Spring Harbor, N.y.); 20; 4; 5-2013; 170-173
1072-0502
1549-5485
url http://hdl.handle.net/11336/17386
identifier_str_mv Katche, Cynthia Lorena; Dorman, Guido; Slipczuk, Leandro; Cammarota, Martin Pablo; Medina, Jorge Horacio; Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory; Cold Spring Harbor Lab Press; Learning & Memory (cold Spring Harbor, N.y.); 20; 4; 5-2013; 170-173
1072-0502
1549-5485
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/20/4/170.full
info:eu-repo/semantics/altIdentifier/doi/10.1101/lm.030080.112
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Lab Press
publisher.none.fl_str_mv Cold Spring Harbor Lab Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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