Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone

Autores
Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats.
Fil: Quintero, Fabian Anibal. Universidad Nacional de La Plata; Argentina
Fil: Orden, Alicia Bibiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Guimarey, Luis Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina
Fil: Fucini, Maria Cecilia. Universidad Nacional de La Plata; Argentina
Fil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina
Materia
Iugr
Bone Maturation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/83491
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Skeletal maturation in intrauterine growth-retarded rats treated with growth hormoneQuintero, Fabian AnibalOrden, Alicia BibianaGuimarey, Luis ManuelFucini, Maria CeciliaOyhenart, Evelia EdithIugrBone Maturationhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats.Fil: Quintero, Fabian Anibal. Universidad Nacional de La Plata; ArgentinaFil: Orden, Alicia Bibiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Guimarey, Luis Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; ArgentinaFil: Fucini, Maria Cecilia. Universidad Nacional de La Plata; ArgentinaFil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; ArgentinaI R O G Canada, Inc2004-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/83491Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith; Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone; I R O G Canada, Inc; Clinical And Experimental Obstetrics & Gynecology.; 31; 2; 6-2004; 130-1320390-6663CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15266768info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:25Zoai:ri.conicet.gov.ar:11336/83491instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:26.151CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
title Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
spellingShingle Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
Quintero, Fabian Anibal
Iugr
Bone Maturation
title_short Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
title_full Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
title_fullStr Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
title_full_unstemmed Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
title_sort Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
dc.creator.none.fl_str_mv Quintero, Fabian Anibal
Orden, Alicia Bibiana
Guimarey, Luis Manuel
Fucini, Maria Cecilia
Oyhenart, Evelia Edith
author Quintero, Fabian Anibal
author_facet Quintero, Fabian Anibal
Orden, Alicia Bibiana
Guimarey, Luis Manuel
Fucini, Maria Cecilia
Oyhenart, Evelia Edith
author_role author
author2 Orden, Alicia Bibiana
Guimarey, Luis Manuel
Fucini, Maria Cecilia
Oyhenart, Evelia Edith
author2_role author
author
author
author
dc.subject.none.fl_str_mv Iugr
Bone Maturation
topic Iugr
Bone Maturation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats.
Fil: Quintero, Fabian Anibal. Universidad Nacional de La Plata; Argentina
Fil: Orden, Alicia Bibiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Guimarey, Luis Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina
Fil: Fucini, Maria Cecilia. Universidad Nacional de La Plata; Argentina
Fil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina
description The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats.
publishDate 2004
dc.date.none.fl_str_mv 2004-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/83491
Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith; Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone; I R O G Canada, Inc; Clinical And Experimental Obstetrics & Gynecology.; 31; 2; 6-2004; 130-132
0390-6663
CONICET Digital
CONICET
url http://hdl.handle.net/11336/83491
identifier_str_mv Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith; Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone; I R O G Canada, Inc; Clinical And Experimental Obstetrics & Gynecology.; 31; 2; 6-2004; 130-132
0390-6663
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15266768
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv I R O G Canada, Inc
publisher.none.fl_str_mv I R O G Canada, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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