Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone
- Autores
- Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith
- Año de publicación
- 2004
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats.
Fil: Quintero, Fabian Anibal. Universidad Nacional de La Plata; Argentina
Fil: Orden, Alicia Bibiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Guimarey, Luis Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina
Fil: Fucini, Maria Cecilia. Universidad Nacional de La Plata; Argentina
Fil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina - Materia
-
Iugr
Bone Maturation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/83491
Ver los metadatos del registro completo
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Skeletal maturation in intrauterine growth-retarded rats treated with growth hormoneQuintero, Fabian AnibalOrden, Alicia BibianaGuimarey, Luis ManuelFucini, Maria CeciliaOyhenart, Evelia EdithIugrBone Maturationhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats.Fil: Quintero, Fabian Anibal. Universidad Nacional de La Plata; ArgentinaFil: Orden, Alicia Bibiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Guimarey, Luis Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; ArgentinaFil: Fucini, Maria Cecilia. Universidad Nacional de La Plata; ArgentinaFil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; ArgentinaI R O G Canada, Inc2004-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/83491Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith; Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone; I R O G Canada, Inc; Clinical And Experimental Obstetrics & Gynecology.; 31; 2; 6-2004; 130-1320390-6663CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15266768info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:52Zoai:ri.conicet.gov.ar:11336/83491instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:53.22CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
title |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
spellingShingle |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone Quintero, Fabian Anibal Iugr Bone Maturation |
title_short |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
title_full |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
title_fullStr |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
title_full_unstemmed |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
title_sort |
Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone |
dc.creator.none.fl_str_mv |
Quintero, Fabian Anibal Orden, Alicia Bibiana Guimarey, Luis Manuel Fucini, Maria Cecilia Oyhenart, Evelia Edith |
author |
Quintero, Fabian Anibal |
author_facet |
Quintero, Fabian Anibal Orden, Alicia Bibiana Guimarey, Luis Manuel Fucini, Maria Cecilia Oyhenart, Evelia Edith |
author_role |
author |
author2 |
Orden, Alicia Bibiana Guimarey, Luis Manuel Fucini, Maria Cecilia Oyhenart, Evelia Edith |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Iugr Bone Maturation |
topic |
Iugr Bone Maturation |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats. Fil: Quintero, Fabian Anibal. Universidad Nacional de La Plata; Argentina Fil: Orden, Alicia Bibiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina Fil: Guimarey, Luis Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina Fil: Fucini, Maria Cecilia. Universidad Nacional de La Plata; Argentina Fil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Antropología. Cátedra de Antropología Biológica IV; Argentina |
description |
The objective of this study was to analyse the effects of intrauterine growth retardation (IUGR) and growth hormone (Gh) therapy on skeletal maturation in growth retarded rats. One-hundred and thirty-five rats constituted the groups: Control (C), Sham-operated (SH), IUGR and IUGR+Gh: injected with Genotropin 3.0 mg/kg/day) from 21 to 60 days of age. SH was injected only with saline solution. The thickness of tibial cartilage was assessed on X-ray at the ages 1, 21, 42, 63 and 84 days and categorised according to three levels. L1: maximal thickness, L2: reduction of 50% and L3: absence. The percentual differences between frequencies for each level were compared and clustered by simple ligation in Euclidean distance. The results lead to us to conclude that skeletal maturation does not appear to be modified by IUGR, while it is accelerated by growth hormone in growth-retarded rats. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/83491 Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith; Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone; I R O G Canada, Inc; Clinical And Experimental Obstetrics & Gynecology.; 31; 2; 6-2004; 130-132 0390-6663 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/83491 |
identifier_str_mv |
Quintero, Fabian Anibal; Orden, Alicia Bibiana; Guimarey, Luis Manuel; Fucini, Maria Cecilia; Oyhenart, Evelia Edith; Skeletal maturation in intrauterine growth-retarded rats treated with growth hormone; I R O G Canada, Inc; Clinical And Experimental Obstetrics & Gynecology.; 31; 2; 6-2004; 130-132 0390-6663 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15266768 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
I R O G Canada, Inc |
publisher.none.fl_str_mv |
I R O G Canada, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268822619291648 |
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13.13397 |