Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections

Autores
Quintero, Cristian Andres; Gambarte Tudela, Julian Alberto; Damiani, Maria Elena
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pathogens have evolved highly specialized mechanisms to infect hosts. Several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. Once internalized, they hijack the molecular machinery of the infected cell for their own benefit. At different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small GTPases. In this review, we focus on the role of Rho proteins on curable, sexually transmitted infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Treponema pallidum. Despite the high, worldwide frequencies of these sexually-transmitted diseases, very little is known about the strategies developed by these microorganisms to usurp key eukaryotic proteins that control intracellular signaling and actin dynamics. Improved knowledge of these molecular mechanisms will contribute to the elucidation of how these clinically important pathogens manipulate intracellular processes and parasitize their hosts.
Fil: Quintero, Cristian Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Gambarte Tudela, Julian Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Damiani, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Materia
CDC42
CHLAMYDIA TRACHOMATIS
NEISSERIA GONORRHOEAE
PATHOGEN-HOST CELL INTERACTION
PATHOGENS
RAC1
RHO
SMALL GTPASES
TREPONEMA PALLIDUM
TRICHOMONAS VAGINALIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41057
Acceder
id CONICETDig_cb33828c43dfc6fbdd8882d7c5aca05b
oai_identifier_str oai:ri.conicet.gov.ar:11336/41057
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rho GTPases as pathogen targets: Focus on curable sexually transmitted infectionsQuintero, Cristian AndresGambarte Tudela, Julian AlbertoDamiani, Maria ElenaCDC42CHLAMYDIA TRACHOMATISNEISSERIA GONORRHOEAEPATHOGEN-HOST CELL INTERACTIONPATHOGENSRAC1RHOSMALL GTPASESTREPONEMA PALLIDUMTRICHOMONAS VAGINALIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Pathogens have evolved highly specialized mechanisms to infect hosts. Several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. Once internalized, they hijack the molecular machinery of the infected cell for their own benefit. At different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small GTPases. In this review, we focus on the role of Rho proteins on curable, sexually transmitted infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Treponema pallidum. Despite the high, worldwide frequencies of these sexually-transmitted diseases, very little is known about the strategies developed by these microorganisms to usurp key eukaryotic proteins that control intracellular signaling and actin dynamics. Improved knowledge of these molecular mechanisms will contribute to the elucidation of how these clinically important pathogens manipulate intracellular processes and parasitize their hosts.Fil: Quintero, Cristian Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Gambarte Tudela, Julian Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Damiani, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaTaylor & Francis2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41057Quintero, Cristian Andres; Gambarte Tudela, Julian Alberto; Damiani, Maria Elena; Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections; Taylor & Francis; Small GTPases; 6; 2; 5-2015; 108-1182154-1248CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4161/21541248.2014.991233info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/21541248.2014.991233info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:37:40Zoai:ri.conicet.gov.ar:11336/41057instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:37:40.696CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
title Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
spellingShingle Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
Quintero, Cristian Andres
CDC42
CHLAMYDIA TRACHOMATIS
NEISSERIA GONORRHOEAE
PATHOGEN-HOST CELL INTERACTION
PATHOGENS
RAC1
RHO
SMALL GTPASES
TREPONEMA PALLIDUM
TRICHOMONAS VAGINALIS
title_short Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
title_full Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
title_fullStr Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
title_full_unstemmed Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
title_sort Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
dc.creator.none.fl_str_mv Quintero, Cristian Andres
Gambarte Tudela, Julian Alberto
Damiani, Maria Elena
author Quintero, Cristian Andres
author_facet Quintero, Cristian Andres
Gambarte Tudela, Julian Alberto
Damiani, Maria Elena
author_role author
author2 Gambarte Tudela, Julian Alberto
Damiani, Maria Elena
author2_role author
author
dc.subject.none.fl_str_mv CDC42
CHLAMYDIA TRACHOMATIS
NEISSERIA GONORRHOEAE
PATHOGEN-HOST CELL INTERACTION
PATHOGENS
RAC1
RHO
SMALL GTPASES
TREPONEMA PALLIDUM
TRICHOMONAS VAGINALIS
topic CDC42
CHLAMYDIA TRACHOMATIS
NEISSERIA GONORRHOEAE
PATHOGEN-HOST CELL INTERACTION
PATHOGENS
RAC1
RHO
SMALL GTPASES
TREPONEMA PALLIDUM
TRICHOMONAS VAGINALIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pathogens have evolved highly specialized mechanisms to infect hosts. Several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. Once internalized, they hijack the molecular machinery of the infected cell for their own benefit. At different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small GTPases. In this review, we focus on the role of Rho proteins on curable, sexually transmitted infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Treponema pallidum. Despite the high, worldwide frequencies of these sexually-transmitted diseases, very little is known about the strategies developed by these microorganisms to usurp key eukaryotic proteins that control intracellular signaling and actin dynamics. Improved knowledge of these molecular mechanisms will contribute to the elucidation of how these clinically important pathogens manipulate intracellular processes and parasitize their hosts.
Fil: Quintero, Cristian Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Gambarte Tudela, Julian Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Damiani, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
description Pathogens have evolved highly specialized mechanisms to infect hosts. Several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. Once internalized, they hijack the molecular machinery of the infected cell for their own benefit. At different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small GTPases. In this review, we focus on the role of Rho proteins on curable, sexually transmitted infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Treponema pallidum. Despite the high, worldwide frequencies of these sexually-transmitted diseases, very little is known about the strategies developed by these microorganisms to usurp key eukaryotic proteins that control intracellular signaling and actin dynamics. Improved knowledge of these molecular mechanisms will contribute to the elucidation of how these clinically important pathogens manipulate intracellular processes and parasitize their hosts.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41057
Quintero, Cristian Andres; Gambarte Tudela, Julian Alberto; Damiani, Maria Elena; Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections; Taylor & Francis; Small GTPases; 6; 2; 5-2015; 108-118
2154-1248
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41057
identifier_str_mv Quintero, Cristian Andres; Gambarte Tudela, Julian Alberto; Damiani, Maria Elena; Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections; Taylor & Francis; Small GTPases; 6; 2; 5-2015; 108-118
2154-1248
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4161/21541248.2014.991233
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/21541248.2014.991233
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083497077243904
score 13.22299

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