An unaware agenda: Interictal consciousness impairments in epileptic patients

Autores
Moguilner, Sebastian Gabriel; García, Adolfo Martín; Mikulan, Ezequiel Pablo; García, Maria del Carmen; Vaucheret, Esteban; Amarillo Gómez, Yimy; Bekinchstein, Tristán; Ibáñez Barassi, Agustín Mariano
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, while focal seizures have more variable degrees of responsiveness. In addition to these impairments that occur during ictal episodes, alterations of consciousness have also been repeatedly observed between seizures (i.e., during interictal periods). In this opinion paper, we review evidence supporting the novel hypothesis that epilepsy produces consciousness impairments which remain present interictally. Then, we discuss therapies aimed to reduce seizure frequency, which may modulate consciousness between epileptic seizures. We conclude with a consideration of relevant pathophysiological mechanisms. In particular, the thalamocortical network seems to be involved in both seizure generation and interictal consciousness impairments, which could inaugurate a promising translational agenda for epilepsy studies.
Fil: Moguilner, Sebastian Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina. Fundación Escuela de Medicina Nuclear; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Fil: García, Maria del Carmen. Hospital Italiano; Argentina
Fil: Vaucheret, Esteban. Hospital Italiano; Argentina
Fil: Amarillo Gómez, Yimy. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bekinchstein, Tristán. University of Cambridge; Reino Unido
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Autonoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Materia
Epilepsy
Interictal Period
Consciousness Impairments
Therapy
Thalamocortical Network
Interictal Epileptic Discharges
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59142
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An unaware agenda: Interictal consciousness impairments in epileptic patientsMoguilner, Sebastian GabrielGarcía, Adolfo MartínMikulan, Ezequiel PabloGarcía, Maria del CarmenVaucheret, EstebanAmarillo Gómez, YimyBekinchstein, TristánIbáñez Barassi, Agustín MarianoEpilepsyInterictal PeriodConsciousness ImpairmentsTherapyThalamocortical NetworkInterictal Epileptic Dischargeshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, while focal seizures have more variable degrees of responsiveness. In addition to these impairments that occur during ictal episodes, alterations of consciousness have also been repeatedly observed between seizures (i.e., during interictal periods). In this opinion paper, we review evidence supporting the novel hypothesis that epilepsy produces consciousness impairments which remain present interictally. Then, we discuss therapies aimed to reduce seizure frequency, which may modulate consciousness between epileptic seizures. We conclude with a consideration of relevant pathophysiological mechanisms. In particular, the thalamocortical network seems to be involved in both seizure generation and interictal consciousness impairments, which could inaugurate a promising translational agenda for epilepsy studies.Fil: Moguilner, Sebastian Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina. Fundación Escuela de Medicina Nuclear; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; ArgentinaFil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; ArgentinaFil: García, Maria del Carmen. Hospital Italiano; ArgentinaFil: Vaucheret, Esteban. Hospital Italiano; ArgentinaFil: Amarillo Gómez, Yimy. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bekinchstein, Tristán. University of Cambridge; Reino UnidoFil: Ibáñez Barassi, Agustín Mariano. Universidad Autonoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; ArgentinaOxford University Press2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59142Moguilner, Sebastian Gabriel; García, Adolfo Martín; Mikulan, Ezequiel Pablo; García, Maria del Carmen; Vaucheret, Esteban; et al.; An unaware agenda: Interictal consciousness impairments in epileptic patients; Oxford University Press; Neuroscience of Consciousness; 2017; 1; 1-2017; 1-102057-2107CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/nc/niw024info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nc/article/2017/1/niw024/2960733info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:46:23Zoai:ri.conicet.gov.ar:11336/59142instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:46:23.854CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An unaware agenda: Interictal consciousness impairments in epileptic patients
title An unaware agenda: Interictal consciousness impairments in epileptic patients
spellingShingle An unaware agenda: Interictal consciousness impairments in epileptic patients
Moguilner, Sebastian Gabriel
Epilepsy
Interictal Period
Consciousness Impairments
Therapy
Thalamocortical Network
Interictal Epileptic Discharges
title_short An unaware agenda: Interictal consciousness impairments in epileptic patients
title_full An unaware agenda: Interictal consciousness impairments in epileptic patients
title_fullStr An unaware agenda: Interictal consciousness impairments in epileptic patients
title_full_unstemmed An unaware agenda: Interictal consciousness impairments in epileptic patients
title_sort An unaware agenda: Interictal consciousness impairments in epileptic patients
dc.creator.none.fl_str_mv Moguilner, Sebastian Gabriel
García, Adolfo Martín
Mikulan, Ezequiel Pablo
García, Maria del Carmen
Vaucheret, Esteban
Amarillo Gómez, Yimy
Bekinchstein, Tristán
Ibáñez Barassi, Agustín Mariano
author Moguilner, Sebastian Gabriel
author_facet Moguilner, Sebastian Gabriel
García, Adolfo Martín
Mikulan, Ezequiel Pablo
García, Maria del Carmen
Vaucheret, Esteban
Amarillo Gómez, Yimy
Bekinchstein, Tristán
Ibáñez Barassi, Agustín Mariano
author_role author
author2 García, Adolfo Martín
Mikulan, Ezequiel Pablo
García, Maria del Carmen
Vaucheret, Esteban
Amarillo Gómez, Yimy
Bekinchstein, Tristán
Ibáñez Barassi, Agustín Mariano
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epilepsy
Interictal Period
Consciousness Impairments
Therapy
Thalamocortical Network
Interictal Epileptic Discharges
topic Epilepsy
Interictal Period
Consciousness Impairments
Therapy
Thalamocortical Network
Interictal Epileptic Discharges
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, while focal seizures have more variable degrees of responsiveness. In addition to these impairments that occur during ictal episodes, alterations of consciousness have also been repeatedly observed between seizures (i.e., during interictal periods). In this opinion paper, we review evidence supporting the novel hypothesis that epilepsy produces consciousness impairments which remain present interictally. Then, we discuss therapies aimed to reduce seizure frequency, which may modulate consciousness between epileptic seizures. We conclude with a consideration of relevant pathophysiological mechanisms. In particular, the thalamocortical network seems to be involved in both seizure generation and interictal consciousness impairments, which could inaugurate a promising translational agenda for epilepsy studies.
Fil: Moguilner, Sebastian Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina. Fundación Escuela de Medicina Nuclear; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Fil: García, Maria del Carmen. Hospital Italiano; Argentina
Fil: Vaucheret, Esteban. Hospital Italiano; Argentina
Fil: Amarillo Gómez, Yimy. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bekinchstein, Tristán. University of Cambridge; Reino Unido
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Autonoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
description Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, while focal seizures have more variable degrees of responsiveness. In addition to these impairments that occur during ictal episodes, alterations of consciousness have also been repeatedly observed between seizures (i.e., during interictal periods). In this opinion paper, we review evidence supporting the novel hypothesis that epilepsy produces consciousness impairments which remain present interictally. Then, we discuss therapies aimed to reduce seizure frequency, which may modulate consciousness between epileptic seizures. We conclude with a consideration of relevant pathophysiological mechanisms. In particular, the thalamocortical network seems to be involved in both seizure generation and interictal consciousness impairments, which could inaugurate a promising translational agenda for epilepsy studies.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59142
Moguilner, Sebastian Gabriel; García, Adolfo Martín; Mikulan, Ezequiel Pablo; García, Maria del Carmen; Vaucheret, Esteban; et al.; An unaware agenda: Interictal consciousness impairments in epileptic patients; Oxford University Press; Neuroscience of Consciousness; 2017; 1; 1-2017; 1-10
2057-2107
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59142
identifier_str_mv Moguilner, Sebastian Gabriel; García, Adolfo Martín; Mikulan, Ezequiel Pablo; García, Maria del Carmen; Vaucheret, Esteban; et al.; An unaware agenda: Interictal consciousness impairments in epileptic patients; Oxford University Press; Neuroscience of Consciousness; 2017; 1; 1-2017; 1-10
2057-2107
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/nc/niw024
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nc/article/2017/1/niw024/2960733
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.221938

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