Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness

Autores
Tao, Pengyou; Perrone, Sofía; Demarchi, Gianina; Chimento, Agustina; Cervio, Andres Eduardo; Sevlever, Gustavo; Berner, Silvia Ines; Becu, Damasia; Basso, Armando J.; Ge, Chen; Ling, Feng; Zhang, Qiuhang; Cristina, Silvia Carolina
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Pituitary adenomas can become invasive and aggressive, and in turn produce tumor recurrence. Endocan or endothelial cell specific molecule-1 (ESM1) has been associated with angiogenesis and tumor growth in gliomas, and lung, kidney, liver among other cancers, but there is a scarcity of information regarding its role in pituitary adenomas. In the search for biomarkers of tumor behavior our objective was to determine the relationship between endocan (ESM1) mRNA expression and cavernous sinus invasion, and its association with gene expression of VEGF, FGF2 and PDGF angiogenic factors in human pituitary adenomas.Methods: ESM1, VEGF, FGF2 and PDGF expression was determined by qRT-PCR in 28 pituitary tumor samples and tumor invasion was determined by the Knosp grade classification. Results were associated with clinical data.Results: We found that ESM1 was expressed in 75% of the tumors. FGF2 expression was higher in ESM1-positive compared to ESM1-negative tumors, and a significant negative correlation in the expression of FGF2 and PDGF was found. Although ESM1 expression did not show any differences in invasive and non-invasive tumors, a positive correlation between ESM1 and Knosp grade was reached when grade 0-3 tumors were considered, suggesting its participation in the initial periods of tumor invasion. Finally, no difference in ESM1 expression was found between functioning and non-functioning adenomas, or patients age.Conclusions: Our study points to a precise pattern of angiogenic factor expression in pituitary tumors, and its relation to invasive behavior, which should be considered in the tailoring of drug treatments for aggressive and resistant pituitary adenomas.
Fil: Tao, Pengyou. Xuanwu Hospital; China
Fil: Perrone, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Chimento, Agustina. Universidad Nacional del Noroeste de la Pcia.de Bs.as.. Instituto de Diseño E Investigacion. - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires. Instituto de Diseño E Investigacion.; Argentina
Fil: Cervio, Andres Eduardo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Berner, Silvia Ines. Clinica Santa Isabel; Argentina
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Basso, Armando J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Instituto de Neurociencias Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ge, Chen. Xuanwu Hospital; China
Fil: Ling, Feng. Xuanwu Hospital; China
Fil: Zhang, Qiuhang. Xuanwu Hospital; China
Fil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Materia
ANGIOGENESIS
ENDOCAN
INVASION
PITUITARY
PDGF
FGF
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/164131
Acceder
id CONICETDig_ca7422aec062c5725540da7710d53dab
oai_identifier_str oai:ri.conicet.gov.ar:11336/164131
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor InvasivenessTao, PengyouPerrone, SofíaDemarchi, GianinaChimento, AgustinaCervio, Andres EduardoSevlever, GustavoBerner, Silvia InesBecu, DamasiaBasso, Armando J.Ge, ChenLing, FengZhang, QiuhangCristina, Silvia CarolinaANGIOGENESISENDOCANINVASIONPITUITARYPDGFFGFhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Pituitary adenomas can become invasive and aggressive, and in turn produce tumor recurrence. Endocan or endothelial cell specific molecule-1 (ESM1) has been associated with angiogenesis and tumor growth in gliomas, and lung, kidney, liver among other cancers, but there is a scarcity of information regarding its role in pituitary adenomas. In the search for biomarkers of tumor behavior our objective was to determine the relationship between endocan (ESM1) mRNA expression and cavernous sinus invasion, and its association with gene expression of VEGF, FGF2 and PDGF angiogenic factors in human pituitary adenomas.Methods: ESM1, VEGF, FGF2 and PDGF expression was determined by qRT-PCR in 28 pituitary tumor samples and tumor invasion was determined by the Knosp grade classification. Results were associated with clinical data.Results: We found that ESM1 was expressed in 75% of the tumors. FGF2 expression was higher in ESM1-positive compared to ESM1-negative tumors, and a significant negative correlation in the expression of FGF2 and PDGF was found. Although ESM1 expression did not show any differences in invasive and non-invasive tumors, a positive correlation between ESM1 and Knosp grade was reached when grade 0-3 tumors were considered, suggesting its participation in the initial periods of tumor invasion. Finally, no difference in ESM1 expression was found between functioning and non-functioning adenomas, or patients age.Conclusions: Our study points to a precise pattern of angiogenic factor expression in pituitary tumors, and its relation to invasive behavior, which should be considered in the tailoring of drug treatments for aggressive and resistant pituitary adenomas.Fil: Tao, Pengyou. Xuanwu Hospital; ChinaFil: Perrone, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Chimento, Agustina. Universidad Nacional del Noroeste de la Pcia.de Bs.as.. Instituto de Diseño E Investigacion. - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires. Instituto de Diseño E Investigacion.; ArgentinaFil: Cervio, Andres Eduardo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Berner, Silvia Ines. Clinica Santa Isabel; ArgentinaFil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Basso, Armando J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Instituto de Neurociencias Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ge, Chen. Xuanwu Hospital; ChinaFil: Ling, Feng. Xuanwu Hospital; ChinaFil: Zhang, Qiuhang. Xuanwu Hospital; ChinaFil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaEditors Advisory Group2021-01-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164131Tao, Pengyou; Perrone, Sofía; Demarchi, Gianina; Chimento, Agustina; Cervio, Andres Eduardo; et al.; Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness; Editors Advisory Group; BMC Endocrine Disorders; 2021; 20-1-2021; 1-151472-6823CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.researchsquare.com/article/rs-150356/v1info:eu-repo/semantics/altIdentifier/doi/10.21203/rs.3.rs-150356/v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:53Zoai:ri.conicet.gov.ar:11336/164131instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:53.873CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
title Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
spellingShingle Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
Tao, Pengyou
ANGIOGENESIS
ENDOCAN
INVASION
PITUITARY
PDGF
FGF
title_short Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
title_full Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
title_fullStr Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
title_full_unstemmed Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
title_sort Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness
dc.creator.none.fl_str_mv Tao, Pengyou
Perrone, Sofía
Demarchi, Gianina
Chimento, Agustina
Cervio, Andres Eduardo
Sevlever, Gustavo
Berner, Silvia Ines
Becu, Damasia
Basso, Armando J.
Ge, Chen
Ling, Feng
Zhang, Qiuhang
Cristina, Silvia Carolina
author Tao, Pengyou
author_facet Tao, Pengyou
Perrone, Sofía
Demarchi, Gianina
Chimento, Agustina
Cervio, Andres Eduardo
Sevlever, Gustavo
Berner, Silvia Ines
Becu, Damasia
Basso, Armando J.
Ge, Chen
Ling, Feng
Zhang, Qiuhang
Cristina, Silvia Carolina
author_role author
author2 Perrone, Sofía
Demarchi, Gianina
Chimento, Agustina
Cervio, Andres Eduardo
Sevlever, Gustavo
Berner, Silvia Ines
Becu, Damasia
Basso, Armando J.
Ge, Chen
Ling, Feng
Zhang, Qiuhang
Cristina, Silvia Carolina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANGIOGENESIS
ENDOCAN
INVASION
PITUITARY
PDGF
FGF
topic ANGIOGENESIS
ENDOCAN
INVASION
PITUITARY
PDGF
FGF
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Pituitary adenomas can become invasive and aggressive, and in turn produce tumor recurrence. Endocan or endothelial cell specific molecule-1 (ESM1) has been associated with angiogenesis and tumor growth in gliomas, and lung, kidney, liver among other cancers, but there is a scarcity of information regarding its role in pituitary adenomas. In the search for biomarkers of tumor behavior our objective was to determine the relationship between endocan (ESM1) mRNA expression and cavernous sinus invasion, and its association with gene expression of VEGF, FGF2 and PDGF angiogenic factors in human pituitary adenomas.Methods: ESM1, VEGF, FGF2 and PDGF expression was determined by qRT-PCR in 28 pituitary tumor samples and tumor invasion was determined by the Knosp grade classification. Results were associated with clinical data.Results: We found that ESM1 was expressed in 75% of the tumors. FGF2 expression was higher in ESM1-positive compared to ESM1-negative tumors, and a significant negative correlation in the expression of FGF2 and PDGF was found. Although ESM1 expression did not show any differences in invasive and non-invasive tumors, a positive correlation between ESM1 and Knosp grade was reached when grade 0-3 tumors were considered, suggesting its participation in the initial periods of tumor invasion. Finally, no difference in ESM1 expression was found between functioning and non-functioning adenomas, or patients age.Conclusions: Our study points to a precise pattern of angiogenic factor expression in pituitary tumors, and its relation to invasive behavior, which should be considered in the tailoring of drug treatments for aggressive and resistant pituitary adenomas.
Fil: Tao, Pengyou. Xuanwu Hospital; China
Fil: Perrone, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Chimento, Agustina. Universidad Nacional del Noroeste de la Pcia.de Bs.as.. Instituto de Diseño E Investigacion. - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires. Instituto de Diseño E Investigacion.; Argentina
Fil: Cervio, Andres Eduardo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Berner, Silvia Ines. Clinica Santa Isabel; Argentina
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Basso, Armando J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Instituto de Neurociencias Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ge, Chen. Xuanwu Hospital; China
Fil: Ling, Feng. Xuanwu Hospital; China
Fil: Zhang, Qiuhang. Xuanwu Hospital; China
Fil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
description Background: Pituitary adenomas can become invasive and aggressive, and in turn produce tumor recurrence. Endocan or endothelial cell specific molecule-1 (ESM1) has been associated with angiogenesis and tumor growth in gliomas, and lung, kidney, liver among other cancers, but there is a scarcity of information regarding its role in pituitary adenomas. In the search for biomarkers of tumor behavior our objective was to determine the relationship between endocan (ESM1) mRNA expression and cavernous sinus invasion, and its association with gene expression of VEGF, FGF2 and PDGF angiogenic factors in human pituitary adenomas.Methods: ESM1, VEGF, FGF2 and PDGF expression was determined by qRT-PCR in 28 pituitary tumor samples and tumor invasion was determined by the Knosp grade classification. Results were associated with clinical data.Results: We found that ESM1 was expressed in 75% of the tumors. FGF2 expression was higher in ESM1-positive compared to ESM1-negative tumors, and a significant negative correlation in the expression of FGF2 and PDGF was found. Although ESM1 expression did not show any differences in invasive and non-invasive tumors, a positive correlation between ESM1 and Knosp grade was reached when grade 0-3 tumors were considered, suggesting its participation in the initial periods of tumor invasion. Finally, no difference in ESM1 expression was found between functioning and non-functioning adenomas, or patients age.Conclusions: Our study points to a precise pattern of angiogenic factor expression in pituitary tumors, and its relation to invasive behavior, which should be considered in the tailoring of drug treatments for aggressive and resistant pituitary adenomas.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-20
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164131
Tao, Pengyou; Perrone, Sofía; Demarchi, Gianina; Chimento, Agustina; Cervio, Andres Eduardo; et al.; Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness; Editors Advisory Group; BMC Endocrine Disorders; 2021; 20-1-2021; 1-15
1472-6823
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164131
identifier_str_mv Tao, Pengyou; Perrone, Sofía; Demarchi, Gianina; Chimento, Agustina; Cervio, Andres Eduardo; et al.; Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors: A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness; Editors Advisory Group; BMC Endocrine Disorders; 2021; 20-1-2021; 1-15
1472-6823
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.researchsquare.com/article/rs-150356/v1
info:eu-repo/semantics/altIdentifier/doi/10.21203/rs.3.rs-150356/v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editors Advisory Group
publisher.none.fl_str_mv Editors Advisory Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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