The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data

Autores
Ryabov, Vyacheslav V.; Vyshlov, Evgenii V.; Maslov, Leonid N.; Naryzhnaya, Natalia V.; Mukhomedzyanov, Alexandr V.; Boshchenko, Alla A.; Derkachev, Ivan A.; Kurbatov, Boris K.; Krylatov, Andrey V.; Gombozhapova, Aleksandra E.; Dil, Stanislav V.; Samoylova, Julia O.; Fu, Feng; Pei, Jian-Ming; Sufianova, Galina Z.; Diez, Emiliano Raúl
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Microvascular obstruction (MVO) of coronary arteries promotes an increase in mortality and major adverse cardiac events in patients with acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI). Intramyocardial hemorrhage (IMH) is observed in 41–50% of patients with ST-segment elevation myocardial infarction and PCI. The occurrence of IMH is accompanied by inflammation. There is evidence that microthrombi are not involved in the development of MVO. The appearance of MVO is associated with infarct size, the duration of ischemia of the heart, and myocardial edema. However, there is no conclusive evidence that myocardial edema plays an important role in the development of MVO. There is evidence that platelets, inflammation, Ca+2 overload, neuropeptide Y, and endothelin-1 could be involved in the pathogenesis of MVO. The role of endothelial cell damage in MVO formation remains unclear in patients with AMI and PCI. It is unclear whether nitric oxide production is reduced in patients with MVO. Only indirect evidence on the involvement of inflammation in the development of MVO has been obtained. The role of reactive oxygen species (ROS) in the pathogenesis of MVO is not studied. The role of necroptosis and pyroptosis in the pathogenesis of MVO in patients with AMI and PCI is also not studied. The significance of the balance of thromboxane A2, vasopressin, angiotensin II, and prostacyclin in the formation of MVO is currently unknown. Conclusive evidence regarding the role of coronary artery spasm in the development of MV hasn’t been established. Correlation analysis of the neuropeptide Y, endothelin-1 levels and the MVO size in patients with AMI and PCI has not previously been performed. It is unclear whether epinephrine aggravates reperfusion necrosis of cardiomyocytes. Dual antiplatelet therapy improves the efficacy of PCI in prevention of MVO. It is unknown whether epinephrine or L-type Ca+2 channel blockers result in the long-term improvement of coronary blood flow in patients with MVO.
Fil: Ryabov, Vyacheslav V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Vyshlov, Evgenii V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Maslov, Leonid N.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Naryzhnaya, Natalia V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Mukhomedzyanov, Alexandr V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Boshchenko, Alla A.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Derkachev, Ivan A.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Kurbatov, Boris K.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Krylatov, Andrey V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Gombozhapova, Aleksandra E.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Dil, Stanislav V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Samoylova, Julia O.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Fu, Feng. Fourth Military Medical University; China
Fil: Pei, Jian-Ming. Fourth Military Medical University; China
Fil: Sufianova, Galina Z.. Tyumen State Medical University; Rusia
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana Normal; Argentina
Materia
MICROVASCULAR OBSTRUCTION
MYOCARDIAL INFARCTION
ISCHEMIA
ENDOTHELIAL DYSFUNCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267979
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical DataRyabov, Vyacheslav V.Vyshlov, Evgenii V.Maslov, Leonid N.Naryzhnaya, Natalia V.Mukhomedzyanov, Alexandr V.Boshchenko, Alla A.Derkachev, Ivan A.Kurbatov, Boris K.Krylatov, Andrey V.Gombozhapova, Aleksandra E.Dil, Stanislav V.Samoylova, Julia O.Fu, FengPei, Jian-MingSufianova, Galina Z.Diez, Emiliano RaúlMICROVASCULAR OBSTRUCTIONMYOCARDIAL INFARCTIONISCHEMIAENDOTHELIAL DYSFUNCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Microvascular obstruction (MVO) of coronary arteries promotes an increase in mortality and major adverse cardiac events in patients with acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI). Intramyocardial hemorrhage (IMH) is observed in 41–50% of patients with ST-segment elevation myocardial infarction and PCI. The occurrence of IMH is accompanied by inflammation. There is evidence that microthrombi are not involved in the development of MVO. The appearance of MVO is associated with infarct size, the duration of ischemia of the heart, and myocardial edema. However, there is no conclusive evidence that myocardial edema plays an important role in the development of MVO. There is evidence that platelets, inflammation, Ca+2 overload, neuropeptide Y, and endothelin-1 could be involved in the pathogenesis of MVO. The role of endothelial cell damage in MVO formation remains unclear in patients with AMI and PCI. It is unclear whether nitric oxide production is reduced in patients with MVO. Only indirect evidence on the involvement of inflammation in the development of MVO has been obtained. The role of reactive oxygen species (ROS) in the pathogenesis of MVO is not studied. The role of necroptosis and pyroptosis in the pathogenesis of MVO in patients with AMI and PCI is also not studied. The significance of the balance of thromboxane A2, vasopressin, angiotensin II, and prostacyclin in the formation of MVO is currently unknown. Conclusive evidence regarding the role of coronary artery spasm in the development of MV hasn’t been established. Correlation analysis of the neuropeptide Y, endothelin-1 levels and the MVO size in patients with AMI and PCI has not previously been performed. It is unclear whether epinephrine aggravates reperfusion necrosis of cardiomyocytes. Dual antiplatelet therapy improves the efficacy of PCI in prevention of MVO. It is unknown whether epinephrine or L-type Ca+2 channel blockers result in the long-term improvement of coronary blood flow in patients with MVO.Fil: Ryabov, Vyacheslav V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Vyshlov, Evgenii V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Maslov, Leonid N.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Naryzhnaya, Natalia V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Mukhomedzyanov, Alexandr V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Boshchenko, Alla A.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Derkachev, Ivan A.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Kurbatov, Boris K.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Krylatov, Andrey V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Gombozhapova, Aleksandra E.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Dil, Stanislav V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Samoylova, Julia O.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; RusiaFil: Fu, Feng. Fourth Military Medical University; ChinaFil: Pei, Jian-Ming. Fourth Military Medical University; ChinaFil: Sufianova, Galina Z.. Tyumen State Medical University; RusiaFil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana Normal; ArgentinaIMR Press2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267979Ryabov, Vyacheslav V.; Vyshlov, Evgenii V.; Maslov, Leonid N.; Naryzhnaya, Natalia V.; Mukhomedzyanov, Alexandr V.; et al.; The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data; IMR Press; Reviews In Cardiovascular Medicine; 25; 3; 3-2024; 1-131530-6550CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.imrpress.com/journal/RCM/25/3/10.31083/j.rcm2503105info:eu-repo/semantics/altIdentifier/doi/10.31083/j.rcm2503105info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:07:40Zoai:ri.conicet.gov.ar:11336/267979instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:07:40.325CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
title The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
spellingShingle The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
Ryabov, Vyacheslav V.
MICROVASCULAR OBSTRUCTION
MYOCARDIAL INFARCTION
ISCHEMIA
ENDOTHELIAL DYSFUNCTION
title_short The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
title_full The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
title_fullStr The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
title_full_unstemmed The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
title_sort The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data
dc.creator.none.fl_str_mv Ryabov, Vyacheslav V.
Vyshlov, Evgenii V.
Maslov, Leonid N.
Naryzhnaya, Natalia V.
Mukhomedzyanov, Alexandr V.
Boshchenko, Alla A.
Derkachev, Ivan A.
Kurbatov, Boris K.
Krylatov, Andrey V.
Gombozhapova, Aleksandra E.
Dil, Stanislav V.
Samoylova, Julia O.
Fu, Feng
Pei, Jian-Ming
Sufianova, Galina Z.
Diez, Emiliano Raúl
author Ryabov, Vyacheslav V.
author_facet Ryabov, Vyacheslav V.
Vyshlov, Evgenii V.
Maslov, Leonid N.
Naryzhnaya, Natalia V.
Mukhomedzyanov, Alexandr V.
Boshchenko, Alla A.
Derkachev, Ivan A.
Kurbatov, Boris K.
Krylatov, Andrey V.
Gombozhapova, Aleksandra E.
Dil, Stanislav V.
Samoylova, Julia O.
Fu, Feng
Pei, Jian-Ming
Sufianova, Galina Z.
Diez, Emiliano Raúl
author_role author
author2 Vyshlov, Evgenii V.
Maslov, Leonid N.
Naryzhnaya, Natalia V.
Mukhomedzyanov, Alexandr V.
Boshchenko, Alla A.
Derkachev, Ivan A.
Kurbatov, Boris K.
Krylatov, Andrey V.
Gombozhapova, Aleksandra E.
Dil, Stanislav V.
Samoylova, Julia O.
Fu, Feng
Pei, Jian-Ming
Sufianova, Galina Z.
Diez, Emiliano Raúl
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MICROVASCULAR OBSTRUCTION
MYOCARDIAL INFARCTION
ISCHEMIA
ENDOTHELIAL DYSFUNCTION
topic MICROVASCULAR OBSTRUCTION
MYOCARDIAL INFARCTION
ISCHEMIA
ENDOTHELIAL DYSFUNCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Microvascular obstruction (MVO) of coronary arteries promotes an increase in mortality and major adverse cardiac events in patients with acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI). Intramyocardial hemorrhage (IMH) is observed in 41–50% of patients with ST-segment elevation myocardial infarction and PCI. The occurrence of IMH is accompanied by inflammation. There is evidence that microthrombi are not involved in the development of MVO. The appearance of MVO is associated with infarct size, the duration of ischemia of the heart, and myocardial edema. However, there is no conclusive evidence that myocardial edema plays an important role in the development of MVO. There is evidence that platelets, inflammation, Ca+2 overload, neuropeptide Y, and endothelin-1 could be involved in the pathogenesis of MVO. The role of endothelial cell damage in MVO formation remains unclear in patients with AMI and PCI. It is unclear whether nitric oxide production is reduced in patients with MVO. Only indirect evidence on the involvement of inflammation in the development of MVO has been obtained. The role of reactive oxygen species (ROS) in the pathogenesis of MVO is not studied. The role of necroptosis and pyroptosis in the pathogenesis of MVO in patients with AMI and PCI is also not studied. The significance of the balance of thromboxane A2, vasopressin, angiotensin II, and prostacyclin in the formation of MVO is currently unknown. Conclusive evidence regarding the role of coronary artery spasm in the development of MV hasn’t been established. Correlation analysis of the neuropeptide Y, endothelin-1 levels and the MVO size in patients with AMI and PCI has not previously been performed. It is unclear whether epinephrine aggravates reperfusion necrosis of cardiomyocytes. Dual antiplatelet therapy improves the efficacy of PCI in prevention of MVO. It is unknown whether epinephrine or L-type Ca+2 channel blockers result in the long-term improvement of coronary blood flow in patients with MVO.
Fil: Ryabov, Vyacheslav V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Vyshlov, Evgenii V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Maslov, Leonid N.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Naryzhnaya, Natalia V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Mukhomedzyanov, Alexandr V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Boshchenko, Alla A.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Derkachev, Ivan A.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Kurbatov, Boris K.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Krylatov, Andrey V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Gombozhapova, Aleksandra E.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Dil, Stanislav V.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Samoylova, Julia O.. Russian Academy of Sciences. Tomsk National Research Medical Center. Federal State Budgetary Scientific Institution. Cardiology Research Institute; Rusia
Fil: Fu, Feng. Fourth Military Medical University; China
Fil: Pei, Jian-Ming. Fourth Military Medical University; China
Fil: Sufianova, Galina Z.. Tyumen State Medical University; Rusia
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana Normal; Argentina
description Microvascular obstruction (MVO) of coronary arteries promotes an increase in mortality and major adverse cardiac events in patients with acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI). Intramyocardial hemorrhage (IMH) is observed in 41–50% of patients with ST-segment elevation myocardial infarction and PCI. The occurrence of IMH is accompanied by inflammation. There is evidence that microthrombi are not involved in the development of MVO. The appearance of MVO is associated with infarct size, the duration of ischemia of the heart, and myocardial edema. However, there is no conclusive evidence that myocardial edema plays an important role in the development of MVO. There is evidence that platelets, inflammation, Ca+2 overload, neuropeptide Y, and endothelin-1 could be involved in the pathogenesis of MVO. The role of endothelial cell damage in MVO formation remains unclear in patients with AMI and PCI. It is unclear whether nitric oxide production is reduced in patients with MVO. Only indirect evidence on the involvement of inflammation in the development of MVO has been obtained. The role of reactive oxygen species (ROS) in the pathogenesis of MVO is not studied. The role of necroptosis and pyroptosis in the pathogenesis of MVO in patients with AMI and PCI is also not studied. The significance of the balance of thromboxane A2, vasopressin, angiotensin II, and prostacyclin in the formation of MVO is currently unknown. Conclusive evidence regarding the role of coronary artery spasm in the development of MV hasn’t been established. Correlation analysis of the neuropeptide Y, endothelin-1 levels and the MVO size in patients with AMI and PCI has not previously been performed. It is unclear whether epinephrine aggravates reperfusion necrosis of cardiomyocytes. Dual antiplatelet therapy improves the efficacy of PCI in prevention of MVO. It is unknown whether epinephrine or L-type Ca+2 channel blockers result in the long-term improvement of coronary blood flow in patients with MVO.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267979
Ryabov, Vyacheslav V.; Vyshlov, Evgenii V.; Maslov, Leonid N.; Naryzhnaya, Natalia V.; Mukhomedzyanov, Alexandr V.; et al.; The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data; IMR Press; Reviews In Cardiovascular Medicine; 25; 3; 3-2024; 1-13
1530-6550
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267979
identifier_str_mv Ryabov, Vyacheslav V.; Vyshlov, Evgenii V.; Maslov, Leonid N.; Naryzhnaya, Natalia V.; Mukhomedzyanov, Alexandr V.; et al.; The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data; IMR Press; Reviews In Cardiovascular Medicine; 25; 3; 3-2024; 1-13
1530-6550
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.imrpress.com/journal/RCM/25/3/10.31083/j.rcm2503105
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IMR Press
publisher.none.fl_str_mv IMR Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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