Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach

Autores
Cardama, Georgina Alexandra; Lorenzano Menna, Pablo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rac1 has been described as a major player in glioma invasion and progression. The development of novel anti Rac1 inhibitors, such as 1A-116, provides a targeted rational approach to counteract glioma progression. This therapeutic strategy could affect the glioma cell behavior as well as its interplay with the microenvironment. Further studies are needed to validate the effectiveness of this novel molecules and their use in glioma progression.
Fil: Cardama, Georgina Alexandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Lorenzano Menna, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Materia
Glioma
Rho-GTPases
Targeted Terapies
Rational Design
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57448
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approachCardama, Georgina AlexandraLorenzano Menna, PabloGliomaRho-GTPasesTargeted TerapiesRational Designhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Rac1 has been described as a major player in glioma invasion and progression. The development of novel anti Rac1 inhibitors, such as 1A-116, provides a targeted rational approach to counteract glioma progression. This therapeutic strategy could affect the glioma cell behavior as well as its interplay with the microenvironment. Further studies are needed to validate the effectiveness of this novel molecules and their use in glioma progression.Fil: Cardama, Georgina Alexandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Lorenzano Menna, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaSmart Science and Technology2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57448Cardama, Georgina Alexandra; Lorenzano Menna, Pablo; Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach; Smart Science and Technology; Cancer Cell & Microenvironment; 2; 3; 7-2015; 1-42331-0928CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.smartscitech.com/index.php/CCM/article/view/866info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:20:27Zoai:ri.conicet.gov.ar:11336/57448instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:20:28.003CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
title Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
spellingShingle Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
Cardama, Georgina Alexandra
Glioma
Rho-GTPases
Targeted Terapies
Rational Design
title_short Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
title_full Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
title_fullStr Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
title_full_unstemmed Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
title_sort Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach
dc.creator.none.fl_str_mv Cardama, Georgina Alexandra
Lorenzano Menna, Pablo
author Cardama, Georgina Alexandra
author_facet Cardama, Georgina Alexandra
Lorenzano Menna, Pablo
author_role author
author2 Lorenzano Menna, Pablo
author2_role author
dc.subject.none.fl_str_mv Glioma
Rho-GTPases
Targeted Terapies
Rational Design
topic Glioma
Rho-GTPases
Targeted Terapies
Rational Design
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Rac1 has been described as a major player in glioma invasion and progression. The development of novel anti Rac1 inhibitors, such as 1A-116, provides a targeted rational approach to counteract glioma progression. This therapeutic strategy could affect the glioma cell behavior as well as its interplay with the microenvironment. Further studies are needed to validate the effectiveness of this novel molecules and their use in glioma progression.
Fil: Cardama, Georgina Alexandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Lorenzano Menna, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
description Rac1 has been described as a major player in glioma invasion and progression. The development of novel anti Rac1 inhibitors, such as 1A-116, provides a targeted rational approach to counteract glioma progression. This therapeutic strategy could affect the glioma cell behavior as well as its interplay with the microenvironment. Further studies are needed to validate the effectiveness of this novel molecules and their use in glioma progression.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57448
Cardama, Georgina Alexandra; Lorenzano Menna, Pablo; Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach; Smart Science and Technology; Cancer Cell & Microenvironment; 2; 3; 7-2015; 1-4
2331-0928
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57448
identifier_str_mv Cardama, Georgina Alexandra; Lorenzano Menna, Pablo; Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach; Smart Science and Technology; Cancer Cell & Microenvironment; 2; 3; 7-2015; 1-4
2331-0928
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.smartscitech.com/index.php/CCM/article/view/866
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Smart Science and Technology
publisher.none.fl_str_mv Smart Science and Technology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981117592862720
score 12.48226

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