Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
- Autores
- Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; Marcipar, Iván Sergio; Streiger, Mirtha; Arias, Enrique; del Barco, Mónica; Mendicino, Diego; Bottasso, Oscar Adelmo
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.
Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Olivera, Veronica Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Denner, Susana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Diez, Cristina Noemí. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Marcipar, Iván Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Streiger, Mirtha. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: del Barco, Mónica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Mendicino, Diego. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina - Materia
-
Chagas Disease
Humoral Immune Response
Treatment
Myocardial Damage - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/75660
Ver los metadatos del registro completo
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Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damageFabbro, Diana LucreciaOlivera, Veronica SoledadBizai, María LauraDenner, SusanaDiez, Cristina NoemíMarcipar, Iván SergioStreiger, MirthaArias, Enriquedel Barco, MónicaMendicino, DiegoBottasso, Oscar AdelmoChagas DiseaseHumoral Immune ResponseTreatmentMyocardial Damagehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Olivera, Veronica Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Denner, Susana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Diez, Cristina Noemí. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Marcipar, Iván Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Streiger, Mirtha. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: del Barco, Mónica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Mendicino, Diego. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaAmerican Society of Tropical Medicine and Hygiene2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/75660Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; et al.; Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 84; 4; 4-2011; 575-5800002-96371476-1645CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.10-0261info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2011.10-0261info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:25Zoai:ri.conicet.gov.ar:11336/75660instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:26.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
title |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
spellingShingle |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage Fabbro, Diana Lucrecia Chagas Disease Humoral Immune Response Treatment Myocardial Damage |
title_short |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
title_full |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
title_fullStr |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
title_full_unstemmed |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
title_sort |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage |
dc.creator.none.fl_str_mv |
Fabbro, Diana Lucrecia Olivera, Veronica Soledad Bizai, María Laura Denner, Susana Diez, Cristina Noemí Marcipar, Iván Sergio Streiger, Mirtha Arias, Enrique del Barco, Mónica Mendicino, Diego Bottasso, Oscar Adelmo |
author |
Fabbro, Diana Lucrecia |
author_facet |
Fabbro, Diana Lucrecia Olivera, Veronica Soledad Bizai, María Laura Denner, Susana Diez, Cristina Noemí Marcipar, Iván Sergio Streiger, Mirtha Arias, Enrique del Barco, Mónica Mendicino, Diego Bottasso, Oscar Adelmo |
author_role |
author |
author2 |
Olivera, Veronica Soledad Bizai, María Laura Denner, Susana Diez, Cristina Noemí Marcipar, Iván Sergio Streiger, Mirtha Arias, Enrique del Barco, Mónica Mendicino, Diego Bottasso, Oscar Adelmo |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Chagas Disease Humoral Immune Response Treatment Myocardial Damage |
topic |
Chagas Disease Humoral Immune Response Treatment Myocardial Damage |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection. Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Olivera, Veronica Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Denner, Susana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Diez, Cristina Noemí. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Marcipar, Iván Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Streiger, Mirtha. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: del Barco, Mónica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Mendicino, Diego. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina |
description |
We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/75660 Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; et al.; Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 84; 4; 4-2011; 575-580 0002-9637 1476-1645 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/75660 |
identifier_str_mv |
Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; et al.; Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 84; 4; 4-2011; 575-580 0002-9637 1476-1645 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.10-0261 info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2011.10-0261 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613951502942208 |
score |
13.070432 |