Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage

Autores
Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; Marcipar, Iván Sergio; Streiger, Mirtha; Arias, Enrique; del Barco, Mónica; Mendicino, Diego; Bottasso, Oscar Adelmo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.
Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Olivera, Veronica Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Denner, Susana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Diez, Cristina Noemí. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Marcipar, Iván Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Streiger, Mirtha. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: del Barco, Mónica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Mendicino, Diego. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Materia
Chagas Disease
Humoral Immune Response
Treatment
Myocardial Damage
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/75660

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damageFabbro, Diana LucreciaOlivera, Veronica SoledadBizai, María LauraDenner, SusanaDiez, Cristina NoemíMarcipar, Iván SergioStreiger, MirthaArias, Enriquedel Barco, MónicaMendicino, DiegoBottasso, Oscar AdelmoChagas DiseaseHumoral Immune ResponseTreatmentMyocardial Damagehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Olivera, Veronica Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Denner, Susana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Diez, Cristina Noemí. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Marcipar, Iván Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Streiger, Mirtha. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: del Barco, Mónica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Mendicino, Diego. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; ArgentinaAmerican Society of Tropical Medicine and Hygiene2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/75660Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; et al.; Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 84; 4; 4-2011; 575-5800002-96371476-1645CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.10-0261info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2011.10-0261info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:25Zoai:ri.conicet.gov.ar:11336/75660instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:26.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
title Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
spellingShingle Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
Fabbro, Diana Lucrecia
Chagas Disease
Humoral Immune Response
Treatment
Myocardial Damage
title_short Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
title_full Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
title_fullStr Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
title_full_unstemmed Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
title_sort Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage
dc.creator.none.fl_str_mv Fabbro, Diana Lucrecia
Olivera, Veronica Soledad
Bizai, María Laura
Denner, Susana
Diez, Cristina Noemí
Marcipar, Iván Sergio
Streiger, Mirtha
Arias, Enrique
del Barco, Mónica
Mendicino, Diego
Bottasso, Oscar Adelmo
author Fabbro, Diana Lucrecia
author_facet Fabbro, Diana Lucrecia
Olivera, Veronica Soledad
Bizai, María Laura
Denner, Susana
Diez, Cristina Noemí
Marcipar, Iván Sergio
Streiger, Mirtha
Arias, Enrique
del Barco, Mónica
Mendicino, Diego
Bottasso, Oscar Adelmo
author_role author
author2 Olivera, Veronica Soledad
Bizai, María Laura
Denner, Susana
Diez, Cristina Noemí
Marcipar, Iván Sergio
Streiger, Mirtha
Arias, Enrique
del Barco, Mónica
Mendicino, Diego
Bottasso, Oscar Adelmo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas Disease
Humoral Immune Response
Treatment
Myocardial Damage
topic Chagas Disease
Humoral Immune Response
Treatment
Myocardial Damage
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.
Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Olivera, Veronica Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Denner, Susana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Diez, Cristina Noemí. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Marcipar, Iván Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Streiger, Mirtha. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: del Barco, Mónica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Mendicino, Diego. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Invest.sobre Endemias Nacionales; Argentina
description We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
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info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/75660
Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; et al.; Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 84; 4; 4-2011; 575-580
0002-9637
1476-1645
CONICET Digital
CONICET
url http://hdl.handle.net/11336/75660
identifier_str_mv Fabbro, Diana Lucrecia; Olivera, Veronica Soledad; Bizai, María Laura; Denner, Susana; Diez, Cristina Noemí; et al.; Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic chagas disease: Its relationship with treatment against parasites and myocardial damage; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 84; 4; 4-2011; 575-580
0002-9637
1476-1645
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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