Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A

Autores
Sparacino, Javier; Farías, María Gimena; Lamberti, Pedro Walter
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
Fil: Sparacino, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Farías, María Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Lamberti, Pedro Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Materia
MOTORES MOLECULARES
SIMULACIÓN MONTE CARLO
PROCESOS ESTOCÁSTICOS
PROTEÍNAS ASOCIADAS AL MICROTÚBULO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33806
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33806
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1ASparacino, JavierFarías, María GimenaLamberti, Pedro WalterMOTORES MOLECULARESSIMULACIÓN MONTE CARLOPROCESOS ESTOCÁSTICOSPROTEÍNAS ASOCIADAS AL MICROTÚBULOhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.Fil: Sparacino, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Farías, María Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Lamberti, Pedro Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaAmerican Physical Society2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33806Sparacino, Javier; Farías, María Gimena; Lamberti, Pedro Walter; Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 89; 2; 2-2014; 227141-2271481539-3755CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.89.022714info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.89.022714info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:48Zoai:ri.conicet.gov.ar:11336/33806instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:49.106CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
spellingShingle Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
Sparacino, Javier
MOTORES MOLECULARES
SIMULACIÓN MONTE CARLO
PROCESOS ESTOCÁSTICOS
PROTEÍNAS ASOCIADAS AL MICROTÚBULO
title_short Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_full Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_fullStr Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_full_unstemmed Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_sort Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
dc.creator.none.fl_str_mv Sparacino, Javier
Farías, María Gimena
Lamberti, Pedro Walter
author Sparacino, Javier
author_facet Sparacino, Javier
Farías, María Gimena
Lamberti, Pedro Walter
author_role author
author2 Farías, María Gimena
Lamberti, Pedro Walter
author2_role author
author
dc.subject.none.fl_str_mv MOTORES MOLECULARES
SIMULACIÓN MONTE CARLO
PROCESOS ESTOCÁSTICOS
PROTEÍNAS ASOCIADAS AL MICROTÚBULO
topic MOTORES MOLECULARES
SIMULACIÓN MONTE CARLO
PROCESOS ESTOCÁSTICOS
PROTEÍNAS ASOCIADAS AL MICROTÚBULO
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
Fil: Sparacino, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Farías, María Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Lamberti, Pedro Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
description Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33806
Sparacino, Javier; Farías, María Gimena; Lamberti, Pedro Walter; Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 89; 2; 2-2014; 227141-227148
1539-3755
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33806
identifier_str_mv Sparacino, Javier; Farías, María Gimena; Lamberti, Pedro Walter; Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 89; 2; 2-2014; 227141-227148
1539-3755
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.89.022714
info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.89.022714
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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