Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats

Autores
Bardullas, Ulises; Sosa Holt, Carla Solange; Pato, Alejandro Martin; Nemirovsky, Sergio Ivan; Wolansky, Marcelo Javier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical observations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. Endpoints informing on vital determinants ofmammal'smaturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of TTb was the most evident impact on thermoregulation observed starting at ~2-3 h after dosing. Moreover, 15-18 mg/kg BIF induced a mild increase in TTb before the hypothermic action was apparent. The lowest effective dose for temperature perturbationwas 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, respectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a transient increase in TTb (p=0.02) were observed at 1-2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant ratswas quite different from the hyperthermia consistently reported in studies usingmature animals. Our results suggest that body temperaturemonitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats.
Fil: Bardullas, Ulises. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Autónoma de Baja California Sur; México
Fil: Sosa Holt, Carla Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Pato, Alejandro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Nemirovsky, Sergio Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Wolansky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Materia
CUMULATIVE NEUROTOXICITY
INFANCY
PYRETHROIDS
THERMOREGULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182512
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/182512
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant ratsBardullas, UlisesSosa Holt, Carla SolangePato, Alejandro MartinNemirovsky, Sergio IvanWolansky, Marcelo JavierCUMULATIVE NEUROTOXICITYINFANCYPYRETHROIDSTHERMOREGULATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical observations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. Endpoints informing on vital determinants ofmammal'smaturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of TTb was the most evident impact on thermoregulation observed starting at ~2-3 h after dosing. Moreover, 15-18 mg/kg BIF induced a mild increase in TTb before the hypothermic action was apparent. The lowest effective dose for temperature perturbationwas 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, respectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a transient increase in TTb (p=0.02) were observed at 1-2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant ratswas quite different from the hyperthermia consistently reported in studies usingmature animals. Our results suggest that body temperaturemonitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats.Fil: Bardullas, Ulises. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Autónoma de Baja California Sur; MéxicoFil: Sosa Holt, Carla Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Pato, Alejandro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Nemirovsky, Sergio Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Wolansky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaPergamon-Elsevier Science Ltd2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182512Bardullas, Ulises; Sosa Holt, Carla Solange; Pato, Alejandro Martin; Nemirovsky, Sergio Ivan; Wolansky, Marcelo Javier; Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats; Pergamon-Elsevier Science Ltd; Neurotoxicology and Teratology; 52; 11-2015; 1-100892-0362CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0892036215300325info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ntt.2015.09.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:15Zoai:ri.conicet.gov.ar:11336/182512instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:15.311CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
title Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
spellingShingle Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
Bardullas, Ulises
CUMULATIVE NEUROTOXICITY
INFANCY
PYRETHROIDS
THERMOREGULATION
title_short Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
title_full Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
title_fullStr Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
title_full_unstemmed Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
title_sort Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
dc.creator.none.fl_str_mv Bardullas, Ulises
Sosa Holt, Carla Solange
Pato, Alejandro Martin
Nemirovsky, Sergio Ivan
Wolansky, Marcelo Javier
author Bardullas, Ulises
author_facet Bardullas, Ulises
Sosa Holt, Carla Solange
Pato, Alejandro Martin
Nemirovsky, Sergio Ivan
Wolansky, Marcelo Javier
author_role author
author2 Sosa Holt, Carla Solange
Pato, Alejandro Martin
Nemirovsky, Sergio Ivan
Wolansky, Marcelo Javier
author2_role author
author
author
author
dc.subject.none.fl_str_mv CUMULATIVE NEUROTOXICITY
INFANCY
PYRETHROIDS
THERMOREGULATION
topic CUMULATIVE NEUROTOXICITY
INFANCY
PYRETHROIDS
THERMOREGULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical observations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. Endpoints informing on vital determinants ofmammal'smaturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of TTb was the most evident impact on thermoregulation observed starting at ~2-3 h after dosing. Moreover, 15-18 mg/kg BIF induced a mild increase in TTb before the hypothermic action was apparent. The lowest effective dose for temperature perturbationwas 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, respectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a transient increase in TTb (p=0.02) were observed at 1-2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant ratswas quite different from the hyperthermia consistently reported in studies usingmature animals. Our results suggest that body temperaturemonitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats.
Fil: Bardullas, Ulises. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Autónoma de Baja California Sur; México
Fil: Sosa Holt, Carla Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Pato, Alejandro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Nemirovsky, Sergio Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Wolansky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
description Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical observations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. Endpoints informing on vital determinants ofmammal'smaturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of TTb was the most evident impact on thermoregulation observed starting at ~2-3 h after dosing. Moreover, 15-18 mg/kg BIF induced a mild increase in TTb before the hypothermic action was apparent. The lowest effective dose for temperature perturbationwas 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, respectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a transient increase in TTb (p=0.02) were observed at 1-2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant ratswas quite different from the hyperthermia consistently reported in studies usingmature animals. Our results suggest that body temperaturemonitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182512
Bardullas, Ulises; Sosa Holt, Carla Solange; Pato, Alejandro Martin; Nemirovsky, Sergio Ivan; Wolansky, Marcelo Javier; Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats; Pergamon-Elsevier Science Ltd; Neurotoxicology and Teratology; 52; 11-2015; 1-10
0892-0362
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182512
identifier_str_mv Bardullas, Ulises; Sosa Holt, Carla Solange; Pato, Alejandro Martin; Nemirovsky, Sergio Ivan; Wolansky, Marcelo Javier; Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats; Pergamon-Elsevier Science Ltd; Neurotoxicology and Teratology; 52; 11-2015; 1-10
0892-0362
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0892036215300325
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ntt.2015.09.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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