Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
- Autores
- Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; Campos, Rodolfo Hector; Preciado, María Victoria
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.
Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; Alemania
Fil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Compartmentalization
Evolution
Hepatitis C Virus
Pbmc
Pediatric Infection
Population Structure - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/15891
Ver los metadatos del registro completo
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Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in childrenGismondi, Maria InesDíaz Carrasco, Juan MaríaValva, PamelaBecker, Pablo DanielGuzman, Carlos AlbertoCampos, Rodolfo HectorPreciado, María VictoriaCompartmentalizationEvolutionHepatitis C VirusPbmcPediatric InfectionPopulation Structurehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; AlemaniaFil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Inc2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15891Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-1960042-6822enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213005114info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virol.2013.09.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:16Zoai:ri.conicet.gov.ar:11336/15891instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:16.583CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
title |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
spellingShingle |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children Gismondi, Maria Ines Compartmentalization Evolution Hepatitis C Virus Pbmc Pediatric Infection Population Structure |
title_short |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
title_full |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
title_fullStr |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
title_full_unstemmed |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
title_sort |
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children |
dc.creator.none.fl_str_mv |
Gismondi, Maria Ines Díaz Carrasco, Juan María Valva, Pamela Becker, Pablo Daniel Guzman, Carlos Alberto Campos, Rodolfo Hector Preciado, María Victoria |
author |
Gismondi, Maria Ines |
author_facet |
Gismondi, Maria Ines Díaz Carrasco, Juan María Valva, Pamela Becker, Pablo Daniel Guzman, Carlos Alberto Campos, Rodolfo Hector Preciado, María Victoria |
author_role |
author |
author2 |
Díaz Carrasco, Juan María Valva, Pamela Becker, Pablo Daniel Guzman, Carlos Alberto Campos, Rodolfo Hector Preciado, María Victoria |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Compartmentalization Evolution Hepatitis C Virus Pbmc Pediatric Infection Population Structure |
topic |
Compartmentalization Evolution Hepatitis C Virus Pbmc Pediatric Infection Population Structure |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure. Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; Alemania Fil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/15891 Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196 0042-6822 |
url |
http://hdl.handle.net/11336/15891 |
identifier_str_mv |
Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196 0042-6822 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213005114 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virol.2013.09.002 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Inc |
publisher.none.fl_str_mv |
Elsevier Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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