Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children

Autores
Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; Campos, Rodolfo Hector; Preciado, María Victoria
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.
Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; Alemania
Fil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Compartmentalization
Evolution
Hepatitis C Virus
Pbmc
Pediatric Infection
Population Structure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15891

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network_name_str CONICET Digital (CONICET)
spelling Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in childrenGismondi, Maria InesDíaz Carrasco, Juan MaríaValva, PamelaBecker, Pablo DanielGuzman, Carlos AlbertoCampos, Rodolfo HectorPreciado, María VictoriaCompartmentalizationEvolutionHepatitis C VirusPbmcPediatric InfectionPopulation Structurehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; AlemaniaFil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Inc2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15891Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-1960042-6822enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213005114info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virol.2013.09.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:16Zoai:ri.conicet.gov.ar:11336/15891instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:16.583CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
title Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
spellingShingle Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
Gismondi, Maria Ines
Compartmentalization
Evolution
Hepatitis C Virus
Pbmc
Pediatric Infection
Population Structure
title_short Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
title_full Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
title_fullStr Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
title_full_unstemmed Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
title_sort Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
dc.creator.none.fl_str_mv Gismondi, Maria Ines
Díaz Carrasco, Juan María
Valva, Pamela
Becker, Pablo Daniel
Guzman, Carlos Alberto
Campos, Rodolfo Hector
Preciado, María Victoria
author Gismondi, Maria Ines
author_facet Gismondi, Maria Ines
Díaz Carrasco, Juan María
Valva, Pamela
Becker, Pablo Daniel
Guzman, Carlos Alberto
Campos, Rodolfo Hector
Preciado, María Victoria
author_role author
author2 Díaz Carrasco, Juan María
Valva, Pamela
Becker, Pablo Daniel
Guzman, Carlos Alberto
Campos, Rodolfo Hector
Preciado, María Victoria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Compartmentalization
Evolution
Hepatitis C Virus
Pbmc
Pediatric Infection
Population Structure
topic Compartmentalization
Evolution
Hepatitis C Virus
Pbmc
Pediatric Infection
Population Structure
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.
Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; Alemania
Fil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15891
Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196
0042-6822
url http://hdl.handle.net/11336/15891
identifier_str_mv Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196
0042-6822
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213005114
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virol.2013.09.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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