3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study

Autores
Peña, Juan Francisco; Gallo, Loreana Carolina; Cotabarren, Ivana María
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
3D printing is revolutionizing the pharmaceutical industry by enabling personalized drug manufacturing with precise dosages and customized forms, facilitating controlled release profiles and innovative treatments. However, its implementation demands rigorous quality control to ensure safety and efficacy.In this context, magistral compounding combined with 3D printing, offers a promising approach to enhance the personalization of medications. This study aimed to physico-chemically characterize (i.e., FT-IR spectra, DSC thermograms and morphology) the materials used for the 3D printing of capsular devices (CDs), equivalent to size 0 hard gelatin capsules, with 0.4 and 0.9 mm wall thickness (CD-0-0.4 and CD-0-0.9). Losartan potassium, a common antihypertensive, was used as the model drug, and poly(vinyl alcohol) (PVA) was the printing filament. In addition, the stability of the drug inside the CDs was assessed under natural (25°C, 60% RH) and accelerated conditions (40°C, 75% RH) over 1 and 3 months. To this end, the FT-IR spectrum and DSC thermograms of the drug were analyzed and compared to initial values. The physicochemical characterization of the drug and PVA showed the chemical nature and morphology expected for those materials. Regarding drug stability inside CD-0-0.4, FT-IR spectrum and DSC thermogram confirmed no chemical changes in its chemical composition for natural (1 and 3 months) and accelerated conditions (1 month). Conversely, the CDs opened under 3 months accelerated conditions, preventing data acquisition.For CD-0-0.9, FT-IR and DSC confirmed no chemical changes in the drug chemical composition, only in natural conditions. In both accelerated conditions, the CDs opened. The difference in PVA mass between CD-0-0.4 and CD-0-0.9 allowed a higher water sorption that notably affected their structural integrity. In conclusion, CD-0-0.4 and CD-0-0.9 satisfactory preserve the stability of the drug in natural storage conditions.
Fil: Peña, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental
Bahía Blanca
Argentina
Asociación Argentina de Farmacología Experimental
Materia
3D PRITING
CAPSULAR DEVICES
COMPOUNDING PHARMACY
STABILITY STUDY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/276882
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/276882
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability StudyPeña, Juan FranciscoGallo, Loreana CarolinaCotabarren, Ivana María3D PRITINGCAPSULAR DEVICESCOMPOUNDING PHARMACYSTABILITY STUDYhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/23D printing is revolutionizing the pharmaceutical industry by enabling personalized drug manufacturing with precise dosages and customized forms, facilitating controlled release profiles and innovative treatments. However, its implementation demands rigorous quality control to ensure safety and efficacy.In this context, magistral compounding combined with 3D printing, offers a promising approach to enhance the personalization of medications. This study aimed to physico-chemically characterize (i.e., FT-IR spectra, DSC thermograms and morphology) the materials used for the 3D printing of capsular devices (CDs), equivalent to size 0 hard gelatin capsules, with 0.4 and 0.9 mm wall thickness (CD-0-0.4 and CD-0-0.9). Losartan potassium, a common antihypertensive, was used as the model drug, and poly(vinyl alcohol) (PVA) was the printing filament. In addition, the stability of the drug inside the CDs was assessed under natural (25°C, 60% RH) and accelerated conditions (40°C, 75% RH) over 1 and 3 months. To this end, the FT-IR spectrum and DSC thermograms of the drug were analyzed and compared to initial values. The physicochemical characterization of the drug and PVA showed the chemical nature and morphology expected for those materials. Regarding drug stability inside CD-0-0.4, FT-IR spectrum and DSC thermogram confirmed no chemical changes in its chemical composition for natural (1 and 3 months) and accelerated conditions (1 month). Conversely, the CDs opened under 3 months accelerated conditions, preventing data acquisition.For CD-0-0.9, FT-IR and DSC confirmed no chemical changes in the drug chemical composition, only in natural conditions. In both accelerated conditions, the CDs opened. The difference in PVA mass between CD-0-0.4 and CD-0-0.9 allowed a higher water sorption that notably affected their structural integrity. In conclusion, CD-0-0.4 and CD-0-0.9 satisfactory preserve the stability of the drug in natural storage conditions.Fil: Peña, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaFil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaLVI Reunión Anual de la Asociación Argentina de Farmacología ExperimentalBahía BlancaArgentinaAsociación Argentina de Farmacología ExperimentalAsociación Argentina de Farmacología Experimental2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2768823D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 124-124978-631-90806-0-5CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congreso-aafe-2024-2/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T14:15:37Zoai:ri.conicet.gov.ar:11336/276882instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 14:15:38.278CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
title 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
spellingShingle 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
Peña, Juan Francisco
3D PRITING
CAPSULAR DEVICES
COMPOUNDING PHARMACY
STABILITY STUDY
title_short 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
title_full 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
title_fullStr 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
title_full_unstemmed 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
title_sort 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study
dc.creator.none.fl_str_mv Peña, Juan Francisco
Gallo, Loreana Carolina
Cotabarren, Ivana María
author Peña, Juan Francisco
author_facet Peña, Juan Francisco
Gallo, Loreana Carolina
Cotabarren, Ivana María
author_role author
author2 Gallo, Loreana Carolina
Cotabarren, Ivana María
author2_role author
author
dc.subject.none.fl_str_mv 3D PRITING
CAPSULAR DEVICES
COMPOUNDING PHARMACY
STABILITY STUDY
topic 3D PRITING
CAPSULAR DEVICES
COMPOUNDING PHARMACY
STABILITY STUDY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv 3D printing is revolutionizing the pharmaceutical industry by enabling personalized drug manufacturing with precise dosages and customized forms, facilitating controlled release profiles and innovative treatments. However, its implementation demands rigorous quality control to ensure safety and efficacy.In this context, magistral compounding combined with 3D printing, offers a promising approach to enhance the personalization of medications. This study aimed to physico-chemically characterize (i.e., FT-IR spectra, DSC thermograms and morphology) the materials used for the 3D printing of capsular devices (CDs), equivalent to size 0 hard gelatin capsules, with 0.4 and 0.9 mm wall thickness (CD-0-0.4 and CD-0-0.9). Losartan potassium, a common antihypertensive, was used as the model drug, and poly(vinyl alcohol) (PVA) was the printing filament. In addition, the stability of the drug inside the CDs was assessed under natural (25°C, 60% RH) and accelerated conditions (40°C, 75% RH) over 1 and 3 months. To this end, the FT-IR spectrum and DSC thermograms of the drug were analyzed and compared to initial values. The physicochemical characterization of the drug and PVA showed the chemical nature and morphology expected for those materials. Regarding drug stability inside CD-0-0.4, FT-IR spectrum and DSC thermogram confirmed no chemical changes in its chemical composition for natural (1 and 3 months) and accelerated conditions (1 month). Conversely, the CDs opened under 3 months accelerated conditions, preventing data acquisition.For CD-0-0.9, FT-IR and DSC confirmed no chemical changes in the drug chemical composition, only in natural conditions. In both accelerated conditions, the CDs opened. The difference in PVA mass between CD-0-0.4 and CD-0-0.9 allowed a higher water sorption that notably affected their structural integrity. In conclusion, CD-0-0.4 and CD-0-0.9 satisfactory preserve the stability of the drug in natural storage conditions.
Fil: Peña, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental
Bahía Blanca
Argentina
Asociación Argentina de Farmacología Experimental
description 3D printing is revolutionizing the pharmaceutical industry by enabling personalized drug manufacturing with precise dosages and customized forms, facilitating controlled release profiles and innovative treatments. However, its implementation demands rigorous quality control to ensure safety and efficacy.In this context, magistral compounding combined with 3D printing, offers a promising approach to enhance the personalization of medications. This study aimed to physico-chemically characterize (i.e., FT-IR spectra, DSC thermograms and morphology) the materials used for the 3D printing of capsular devices (CDs), equivalent to size 0 hard gelatin capsules, with 0.4 and 0.9 mm wall thickness (CD-0-0.4 and CD-0-0.9). Losartan potassium, a common antihypertensive, was used as the model drug, and poly(vinyl alcohol) (PVA) was the printing filament. In addition, the stability of the drug inside the CDs was assessed under natural (25°C, 60% RH) and accelerated conditions (40°C, 75% RH) over 1 and 3 months. To this end, the FT-IR spectrum and DSC thermograms of the drug were analyzed and compared to initial values. The physicochemical characterization of the drug and PVA showed the chemical nature and morphology expected for those materials. Regarding drug stability inside CD-0-0.4, FT-IR spectrum and DSC thermogram confirmed no chemical changes in its chemical composition for natural (1 and 3 months) and accelerated conditions (1 month). Conversely, the CDs opened under 3 months accelerated conditions, preventing data acquisition.For CD-0-0.9, FT-IR and DSC confirmed no chemical changes in the drug chemical composition, only in natural conditions. In both accelerated conditions, the CDs opened. The difference in PVA mass between CD-0-0.4 and CD-0-0.9 allowed a higher water sorption that notably affected their structural integrity. In conclusion, CD-0-0.4 and CD-0-0.9 satisfactory preserve the stability of the drug in natural storage conditions.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/276882
3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 124-124
978-631-90806-0-5
CONICET Digital
CONICET
url http://hdl.handle.net/11336/276882
identifier_str_mv 3D- Printing Capsular Devices for Compounding Pharmacy: Materials Characterization and Drug Stability Study; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 124-124
978-631-90806-0-5
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congreso-aafe-2024-2/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
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dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Asociación Argentina de Farmacología Experimental
publisher.none.fl_str_mv Asociación Argentina de Farmacología Experimental
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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